Amisulpride versus fluoxetine in dysthymia: preliminary results of a double-blind comparative study

1996 ◽  
Vol 11 (S3) ◽  
pp. 141s-143s ◽  
Author(s):  
E Smeraldi ◽  
E Haefele ◽  
G Crespi ◽  
GL Casadei ◽  
F Biondi ◽  
...  
Keyword(s):  
Comparative Study ◽  
Rating Scale ◽  
Low Doses ◽  
Double Blind Trial ◽  
Efficacy And Safety ◽  
Main Criterion ◽  
Double Blind ◽  
Blind Trial ◽  
Preliminary Results ◽  
Significant Difference

SummaryThe efficacy and safety of low doses of amisulpride (50 mg/day) and of fluoxetine (20 mg/day) were compared respectively in 139 and 129 outpatients with dysthymia during three months in a multi-centre double-blind trial. No statistically significant difference between the two groups was found in the number of responders at study-end with the Montgomery and Asberg Depressive Rating Scale, which was the main criterion for efficacy. In addition, amisulpride was well tolerated. These preliminary results suggest that low doses of amisulpride may be effective in the treatment of dysthymic patients.

S601 EFFICACY AND SAFETY OF A SUBCUTANEOUS DICLOFENAC FORMULATION IN THE MANAGEMENT OF ACUTE PAIN: A RANDOMISED, DOUBLE-BLIND TRIAL

2011 ◽  
Vol 5 (S1) ◽  
pp. 269-270
Author(s):  
T. Dietrich ◽  
R. Leeson ◽  
B. Zielińska-Kaźmierska ◽  
M. Opadczuk ◽  
E. Kozieł ◽  
...  
Keyword(s):  
Acute Pain ◽  
Double Blind Trial ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Blind Trial

Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients

1997 ◽  
Vol 171 (1) ◽  
pp. 73-77 ◽  
Author(s):  
I. Pelc ◽  
P. Verbanck ◽  
O. Le Bon ◽  
M. Gavrilovic ◽  
K. Lion ◽  
...  
Keyword(s):  
Animal Models ◽  
Alcohol Drinking ◽  
Double Blind Trial ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Blind Trial ◽  
Efficacy Parameters ◽  
Clinical Conditions ◽  
Alcohol Dependent

BackgroundAcamprosate is a newly registered drug that appears to reduce alcohol-drinking in both animal models and clinical conditions.MethodIn order to assess the efficacy and safety of the drug in the treatment of detoxified alcoholics, we performed a 90-day double-blind trial comparing two dosages of acamprosate (1332 mg/day and 1998 mg/day).ResultsFor all efficacy parameters, acamprosate appeared to be significantly superior to placebo, with a trend towards a better effect at the higher dosage. Furthermore, acamprosate appeared to be extremely safe.ConclusionThis study confirms that acamprosate could be an interesting adjuvant for maintaining abstinence in detoxified alcoholics.

The Efficacy of Electroconvulsive Therapy in the Treatment of Schizophrenia

1987 ◽  
Vol 151 (2) ◽  
pp. 152-155 ◽  
Author(s):  
K. R. Abraham ◽  
P. Kulhara
Keyword(s):  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Brief Psychiatric Rating Scale ◽  
Psychiatric Rating ◽  
Psychiatric Rating Scale ◽  
To Receive

The efficacy of ECT was investigated in a double-blind trial. Twenty-two patients with schizophrenia received trifluoperazine and were randomly allocated to receive eight real or eight simulated ECTs. In the first eight weeks, the group receiving real ECTs showed significantly more improvement as measured on the Brief Psychiatric Rating Scale. However, the groups showed no significant differences from the twelfth week onwards. The superiority of real ECT was not confirmed at the end of six months.

scholarly journals Double-Blind Trial Comparing Epidural Lignocaine with Epidural Fentanyl for Anaesthesia during Extracorporeal Shock Wave Lithotripsy

1989 ◽  
Vol 17 (1) ◽  
pp. 9-15 ◽  
Author(s):  
B. S. Silbert ◽  
R. Kluger ◽  
A. C. Meads ◽  
K. Stasytis
Keyword(s):  
Shock Wave ◽  
Extracorporeal Shock Wave Lithotripsy ◽  
Shock Wave Lithotripsy ◽  
Epidural Fentanyl ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Extracorporeal Shock Wave ◽  
Significant Difference ◽  
Fentanyl Group

A randomised double-blind trial was undertaken to compare epidural lignocaine 1.5% with adrenaline to epidural fentanyl (100μg in saline 10 ml) in forty unpremedicated patients undergoing extracorporeal shock wave lithotripsy without ancillary procedures. Midazolam only was used for sedation. There was no significant difference in intraoperative pain scores with several patients in each group complaining of pain. Decreases in blood pressure occurred in both groups but were more pronounced in the lignocaine groups (36% vs 25 % maximum decrease from control, P = 0.004). Heart rate was increased in the lignocaine group compared with control and to the fentanyl group, but there was no difference in respiratory rates within or between groups. Pruritis was more common in the fentanyl group and leg heaviness in the lignocaine group, but neither was troublesome. There was no difference in urological outcome at one month. Both techniques were satisfactory for the majority of patients, but the fentanyl group had a shorter preparation time and less cardiovascular changes.

A Double-Blind Trial of Bradilan (Tetranicotinoylfructose) in Perniosis in General Practice

1974 ◽  
Vol 2 (1) ◽  
pp. 56-58 ◽  
Author(s):  
F de S Donnan
Keyword(s):  
General Practice ◽  
Placebo Group ◽  
Comparative Study ◽  
Effective Treatment ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
The Difference

An initial double-blind cross-over study and a subsequent double-blind comparative study against placebo tablets has shown Bradilan (tetranicotinoylfructose) to be an effective treatment of chilblains. The difference between the active and placebo group was highly significant statistically with p < ·001

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