Mild hypothermia provides neuroprotection in an in vitro model of fetal cerebral ischemia.

1996 ◽  
Vol 3 (2) ◽  
pp. 253A ◽  
Author(s):  
R BERGER
Keyword(s):  
Cerebral Ischemia ◽  
In Vitro Model ◽  
Mild Hypothermia ◽  
Vitro Model

scholarly journals Mild Hypothermia Preserves Contractile Function and Inhibits Prostaglandin E2Release from Metabolically Stressed Skeletal Muscle

1994 ◽  
Vol 21 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Valerie A. Cwik ◽  
Ramanath Majumdar ◽  
Michael H. Brooke
Keyword(s):  
Muscle Injury ◽  
In Vitro Model ◽  
Mild Hypothermia ◽  
Contractile Function ◽  
Metabolic Stress ◽  
Ringer Solution ◽  
Vitro Model ◽  
Lactate Levels ◽  
Mitochondrial Uncoupler

Abstract:An in vitro model of muscle damage was used to investigate the protective effect of mild hypothermia in muscle injury. Rat epitrochlearis muscles were dissected in their entirety and suspended in Krebs-Ringer solution and DNP, a mitochondrial uncoupler, was added. PGE2, and lactate release and the contractile response to stimulation were measured and compared to untreated controls. Experiments were done at 37, 35, 33 and 27°C. At 37°C, DNP stimulated muscle releases large amounts of PGE2and lactate and is unable to contract. As the temperature is reduced, there is progressive preservation of contractile force, although high lactate levels at the lowest temperatures indicate that the metabolic stress is still present. In contrast, DNP stimulated PGE2release is completely inhibited at or below 35°C and may be related to a similar protective phenomenon seen in experimental ischemic neuronal death.

Neuroprotective effects of dexmedetomidine conditioning strategies: Evidences from an in vitro model of cerebral ischemia

Life Sciences ◽  
2016 ◽  
Vol 144 ◽  
pp. 162-169 ◽  
Author(s):  
Raquel Rodríguez-González ◽  
Tomás Sobrino ◽  
Sonia Veiga ◽  
Pablo López ◽  
Javier Rodríguez-García ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
In Vitro Model ◽  
Neuroprotective Effects ◽  
Vitro Model

Neuroprotective effects of propofol in an in vitro model of cerebral ischemia

2004 ◽  
Vol 21 (Supplement 32) ◽  
pp. 90
Author(s):  
C. Adembri ◽  
E. Gramigni ◽  
L. Venturi ◽  
A. Chiarugi ◽  
A. R. De Gaudio ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
In Vitro Model ◽  
Neuroprotective Effects ◽  
Vitro Model

scholarly journals Tolerance Induced by (S)-3,5-Dihydroxyphenylglycine Postconditioning is Mediated by the PI3K/Akt/GSK3β Signalling Pathway in an In Vitro Model of Cerebral Ischemia

Neuroscience ◽  
2020 ◽  
Vol 433 ◽  
pp. 221-229 ◽  
Author(s):  
Elisabetta Gerace ◽  
Tania Scartabelli ◽  
Domenico E. Pellegrini-Giampietro ◽  
Elisa Landucci
Keyword(s):  
Cerebral Ischemia ◽  
In Vitro Model ◽  
Signalling Pathway ◽  
Vitro Model
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