Dendritic Cells and Dendritic Cell Subsets

Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses. The importance of DCs migration for their differentiation, phenotypic states, and immunologic functions has attracted widespread attention. In this review, we discussed and compared the chemokines, membrane molecules, and migration patterns of conventional DCs, plasmocytoid DCs, and recently proposed DC subgroups. We also review the promoters and inhibitors that affect DCs migration, including the hypoxia microenvironment, tumor microenvironment, inflammatory factors, and pathogenic microorganisms. Further understanding of the migration mechanisms and regulatory factors of DC subgroups provides new insights for the treatment of diseases, such as infection, tumors, and vaccine preparation.

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From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets

European Journal of Immunology ◽

10.1002/eji.201040498 ◽

2010 ◽

Vol 40 (8) ◽

pp. 2089-2094 ◽

Cited By ~ 103

Author(s):

Martin Guilliams ◽

Sandrine Henri ◽

Samira Tamoutounour ◽

Laurence Ardouin ◽

Isabelle Schwartz-Cornil ◽

...

Keyword(s):

Dendritic Cells ◽

Dendritic Cell ◽

Dendritic Cell Subsets ◽

Mouse Dendritic Cell ◽

Human And Mouse

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Maturation pathways of dendritic cells in vivo: Distinct function, phenotype and localization of lymphoid- and myeloid-derived dendritic cell subsets in FLT3-ligand treated mice

Immunology Letters ◽

10.1016/s0165-2478(97)86082-8 ◽

1997 ◽

Vol 56 ◽

pp. 270 ◽

Cited By ~ 3

Author(s):

B. Pulendran ◽

J. Smith ◽

J. Lingappa ◽

M.K. Kennedy ◽

M. Teepe ◽

...

Keyword(s):

Dendritic Cells ◽

Dendritic Cell ◽

Flt3 Ligand ◽

Dendritic Cell Subsets

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α-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00132.2014 ◽

2014 ◽

Vol 307 (6) ◽

pp. L482-L496 ◽

Cited By ~ 22

Author(s):

Hiam Abdala-Valencia ◽

Sergejs Berdnikovs ◽

Frank W. Soveg ◽

Joan M. Cook-Mills

Keyword(s):

Dendritic Cells ◽

Dendritic Cell ◽

Allergic Disease ◽

Fetal Liver ◽

Allergen Challenge ◽

In Utero ◽

Regulatory Function ◽

Female Mice ◽

Maternal Supplementation ◽

Dendritic Cell Subsets

α-Tocopherol blocks responses to allergen challenge in allergic adult mice, but it is not known whether α-tocopherol regulates the development of allergic disease. Development of allergic disease often occurs early in life. In clinical studies and animal models, offspring of allergic mothers have increased responsiveness to allergen challenge. Therefore, we determined whether α-tocopherol blocked development of allergic responses in offspring of allergic female mice. Allergic female mice were supplemented with α-tocopherol starting at mating. The pups from allergic mothers developed allergic lung responses, whereas pups from saline-treated mothers did not respond to the allergen challenge, and α-tocopherol supplementation of allergic female mice resulted in a dose-dependent reduction in eosinophils in the pup bronchoalveolar lavage and lungs after allergen challenge. There was also a reduction in pup lung CD11b+ dendritic cell subsets that are critical to development of allergic responses, but there was no change in several CD11b− dendritic cell subsets. Furthermore, maternal supplementation with α-tocopherol reduced the number of fetal liver CD11b+ dendritic cells in utero. In the pups, there was reduced allergen-induced lung mRNA expression of IL-4, IL-33, TSLP, CCL11, and CCL24. Cross-fostering pups at the time of birth demonstrated that α-tocopherol had a regulatory function in utero. In conclusion, maternal supplementation with α-tocopherol reduced fetal development of subsets of dendritic cells that are critical for allergic responses and reduced development of allergic responses in pups from allergic mothers. These results have implications for supplementation of allergic mothers with α-tocopherol.

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Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications

International Journal of Molecular Sciences ◽

10.3390/ijms21113930 ◽

2020 ◽

Vol 21 (11) ◽

pp. 3930

Author(s):

Annalisa Del Prete ◽

Francesca Sozio ◽

Ilaria Barbazza ◽

Valentina Salvi ◽

Laura Tiberio ◽

...

Keyword(s):

Dendritic Cells ◽

T Cell ◽

Dendritic Cell ◽

Cancer Progression ◽

Cell Response ◽

Functional Role ◽

T Cell Response ◽

Cytotoxic T Cell ◽

Dendritic Cell Subsets

Dendritic cells (DCs) constitute a complex network of cell subsets with common functions but also with many divergent aspects. All dendritic cell subsets share the ability to prime T cell response and to undergo a complex trafficking program related to their stage of maturation and function. For these reasons, dendritic cells are implicated in a large variety of both protective and detrimental immune responses, including a crucial role in promoting anti-tumor responses. Although cDC1s are the most potent subset in tumor antigen cross-presentation, they are not sufficient to induce full-strength anti-tumor cytotoxic T cell response and need close interaction and cooperativity with the other dendritic cell subsets, namely cDC2s and pDCs. This review will take into consideration different aspects of DC biology, including the functional role of dendritic cell subsets in both fostering and suppressing tumor growth, the mechanisms underlying their recruitment into the tumor microenvironment, as well as the prognostic value and the potentiality of dendritic cell therapeutic targeting. Understanding the specificity of dendritic cell subsets will allow to gain insights on role of these cells in pathological conditions and to design new selective promising therapeutic approaches.

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Pig Skin Includes Dendritic Cell Subsets Transcriptomically Related to Human CD1a and CD14 Dendritic Cells Presenting Different Migrating Behaviors and T Cell Activation Capacities

The Journal of Immunology ◽

10.4049/jimmunol.1303150 ◽

2014 ◽

Vol 193 (12) ◽

pp. 5883-5893 ◽

Cited By ~ 31

Author(s):

Florian Marquet ◽

Thien-Phong Vu Manh ◽

Pauline Maisonnasse ◽

Jamila Elhmouzi-Younes ◽

Céline Urien ◽

...

Keyword(s):

Dendritic Cells ◽

T Cell ◽

Dendritic Cell ◽

T Cell Activation ◽

Cell Activation ◽

Pig Skin ◽

Dendritic Cell Subsets

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The Role of Dendritic Cells in Tissue-Specific Autoimmunity

Journal of Immunology Research ◽

10.1155/2014/857143 ◽

2014 ◽

Vol 2014 ◽

pp. 1-17 ◽

Cited By ~ 46

Author(s):

Jacques Mbongue ◽

Dequina Nicholas ◽

Anthony Firek ◽

William Langridge

Keyword(s):

Dendritic Cells ◽

Dendritic Cell ◽

Clinical Assessment ◽

Tissue Specific ◽

Cell Functions ◽

Research Areas ◽

Systemic Autoimmunity ◽

Dendritic Cell Subsets ◽

Antigen Presenting

In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity. Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented. Further, we compare tissue specific to systemic autoimmunity to demonstrate how development of dendritic cell-based therapies may be broadly applicable to both classes of autoimmunity. Continued development of these research areas will lead us closer to clinical assessment of novel immunosuppressive therapy for the reversal and prevention of tissue-specific autoimmunity. Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.

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