Methods, Measurements, and Interpretation of Animal Lung Function in Health and Disease

2015 ◽  
pp. 305-351 ◽  
Author(s):  
Jeffrey S. Tepper ◽  
Daniel L. Costa
Keyword(s):  
Lung Function ◽  
Health And Disease

scholarly journals Evaluation of lung function among the Indian elite female weightlifters

2017 ◽  
Vol 5 (3) ◽  
pp. 987
Author(s):  
Snehunsu Adhikari ◽  
Adilakshmi Perla ◽  
Suresh Babu Sayana ◽  
Mithilesh K. Tiwari ◽  
Tambi Medabala
Keyword(s):  
Lung Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Lung Function Test ◽  
Forced Expiratory Volume ◽  
Physiological Adaptation ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
Health And Disease

Background: Spirometry is an essential tool to evaluate lung function of health and disease. Adaptability of lung and chest among athletes can be assessed by lung function test (LFT). The quest of our study was to evaluate the lung function (LF) of highly trained Indian female weighting athletes, and intended to appraise the adaptation of LF among trained elite athletes.Methods: Top ranked Indian female professional weightlifters (study group, n=6) were recruited for this study. Three out of the six weightlifters were from top ten world ranking of 6th, 7th and 9th. Age matched controls (control group, n=6) were selected for this study. Maximum voluntary ventilation (MVV), vital capacity (VC), forced vital capacity (FVC), percentage of forced expiratory volume in first second (FEV1%) and ratio of forced expiratory volume in first second and forced vital capacity (FEV1/FVC%) have been evaluated as per the ATS/ERS guidelines.Results: Statistically higher significant values of VC and FVC were noted in study group, where as other values (MVV, FEV1% and FEV1/FVC%) found no significant difference between two groups.Conclusions: Power, strength and explosiveness of the skeletal muscles are vital domains in weightlifting sport. Weightlifting is such a sport doesn’t require much ventilatory efforts during training as well as competition. This study clueing that physiological adaptation/ improvement of the pulmonary function (PF) depends on the type of the sport being engaged by the athletes.

scholarly journals Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Peter B. Noble ◽  
Thomas K. Ansell ◽  
Alan L. James ◽  
Peter K. McFawn ◽  
Howard W. Mitchell
Keyword(s):  
Smooth Muscle ◽  
Lung Function ◽  
Airway Smooth Muscle ◽  
Underlying Mechanism ◽  
Protective Mechanisms ◽  
Functional Abnormality ◽  
Airway Narrowing ◽  
Asthmatic Patients ◽  
Muscle Dynamics ◽  
Health And Disease

The primary functional abnormality in asthma is airway hyperresponsiveness (AHR)—excessive airway narrowing to bronchoconstrictor stimuli. Our understanding of the underlying mechanism(s) producing AHR is incomplete. While structure-function relationships have been evoked to explain AHR (e.g., increased airway smooth muscle (ASM) mass in asthma) more recently there has been a focus on how the dynamic mechanical environment of the lung impacts airway responsiveness in health and disease. The effects of breathing movements such as deep inspiration reveal innate protective mechanisms in healthy individuals that are likely mediated by dynamic ASM stretch but which may be impaired in asthmatic patients and thereby facilitate AHR. This perspective considers the evidence for and against a role of dynamic ASM stretch in limiting the capacity of airways to narrow excessively. We propose that lung function measured after bronchial provocation in the laboratory and changes in lung function perceived by the patient in everyday life may be quite different in their dependence on dynamic ASM stretch.

Lung function trajectories in health and disease

2019 ◽  
Vol 7 (4) ◽  
pp. 358-364 ◽  
Author(s):  
Alvar Agusti ◽  
Rosa Faner
Keyword(s):  
Lung Function ◽  
Health And Disease

Exercise and Lung Function in Child Health and Disease

2019 ◽  
pp. 212-230.e7
Author(s):  
Dan M. Cooper ◽  
Ronen Bar-Yoseph ◽  
J. Tod Olin ◽  
Shlomit Radom-Aizik
Keyword(s):  
Lung Function ◽  
Child Health ◽  
Health And Disease

Drug Induced Changes in Cell Organelles

1968 ◽  
Vol 26 ◽  
pp. 110-111
Author(s):  
Sarah A. Luse
Keyword(s):  
Clinical Medicine ◽  
Cell Organelles ◽  
Riboflavin Deficiency ◽  
Drug Induced ◽  
New Era ◽  
Health And Disease ◽  
In The Beginning ◽  
Cellular Pathology ◽  
Induced Changes ◽  
The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

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