Genetic Correlation Between Cortical Gray Matter Thickness and White Matter Connections

2018 ◽  
pp. 85-100
Author(s):  
Kaikai Shen ◽  
Vincent Doré ◽  
Jurgen Fripp ◽  
Stephen Rose ◽  
Katie L. McMahon ◽  
...  
Keyword(s):  
White Matter ◽  
Genetic Correlation ◽  
Gray Matter ◽  
Cortical Gray Matter

scholarly journals Periventricular White Matter Injury in the Premature Infant Is Associated with a Reduction in Cerebral Cortical Gray Matter Volume at Term

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 343A-343A
Author(s):  
Terrie E Inder ◽  
Petra S Huppi ◽  
Simon Warfield ◽  
Ron Kikinis ◽  
Gary P Zientara ◽  
...  
Keyword(s):  
White Matter ◽  
Premature Infant ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Injury ◽  
Periventricular White Matter ◽  
Matter Volume ◽  
Cortical Gray Matter

scholarly journals Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns

2019 ◽  
Vol 116 (50) ◽  
pp. 25243-25249
Author(s):  
Joshua Chiappelli ◽  
Laura M. Rowland ◽  
S. Andrea Wijtenburg ◽  
Hongji Chen ◽  
Andrew A. Maudsley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
White Matter ◽  
Cardiovascular Risk Factors ◽  
Gray Matter ◽  
Lipid Synthesis ◽  
Cardiovascular Risks ◽  
Myelin Lipid ◽  
Cortical Gray Matter ◽  
The Brain

Cardiovascular risk factors such as dyslipidemia and hypertension increase the risk for white matter pathology and cognitive decline. We hypothesize that white matter levels of N-acetylaspartate (NAA), a chemical involved in the metabolic pathway for myelin lipid synthesis, could serve as a biomarker that tracks the influence of cardiovascular risk factors on white matter prior to emergence of clinical changes. To test this, we measured levels of NAA across white matter and gray matter in the brain using echo planar spectroscopic imaging (EPSI) in 163 individuals and examined the relationship of regional NAA levels and cardiovascular risk factors as indexed by the Framingham Cardiovascular Risk Score (FCVRS). NAA was strongly and negatively correlated with FCVRS across the brain, but, after accounting for age and sex, the association was found primarily in white matter regions, with additional effects found in the thalamus, hippocampus, and cingulate gyrus. FCVRS was also negatively correlated with creatine levels, again primarily in white matter. The results suggest that cardiovascular risks are related to neurochemistry with a predominantly white matter pattern and some subcortical and cortical gray matter involvement. NAA mapping of the brain may provide early surveillance for the potential subclinical impact of cardiovascular and metabolic risk factors on the brain.

Predictors for cortical gray matter volume in stroke patients with confluent white matter changes

2014 ◽  
Vol 338 (1-2) ◽  
pp. 169-173 ◽  
Author(s):  
Yunyun Xiong ◽  
Adrian Wong ◽  
Kelvin Wong ◽  
Winnie C.W. Chu ◽  
Xintao Hu ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Stroke Patients ◽  
White Matter Changes ◽  
Matter Volume ◽  
Cortical Gray Matter

scholarly journals Development of superficial white matter and its structural interplay with cortical gray matter in children and adolescents

2013 ◽  
Vol 35 (6) ◽  
pp. 2806-2816 ◽  
Author(s):  
Minjie Wu ◽  
Lisa H. Lu ◽  
Allison Lowes ◽  
Shaolin Yang ◽  
Alessandra M. Passarotti ◽  
...  
Keyword(s):  
White Matter ◽  
Children And Adolescents ◽  
Gray Matter ◽  
Cortical Gray Matter
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