3D and 4D printing of pH-responsive and functional polymers and their composites

The advancement in 3D printing has led to the rapid growth of 4D printing technology. Adding time, as the fourth dimension, this technology ushered the potential of a massive evolution in fields of biomedical technologies, space applications, deployable structures, manufacturing industries, and so forth. This technology performs ingenious design, using smart materials to create advanced forms of the 3-D printed specimen. Improvements in Computer-aided design, additive manufacturing process, and material science engineering have ultimately favored the growth of 4-D printing innovation and revealed an effective method to gather complex 3-D structures. Contrast to all these developments, novel material is still a challenging sector. However, this short review illustrates the basic of 4D printing, summarizes the stimuli responsive materials properties, which have prominent role in the field of 4D technology. In addition, the practical applications are depicted and the potential prospect of this technology is put forward.

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SuFExable Polymers with Helical Structures Derived from Thionyl Tetrafluoride (SOF4)

10.26434/chemrxiv.10005758 ◽

2019 ◽

Author(s):

Suhua Li ◽

Gencheng Li ◽

Bing Gao ◽

Sidharam P. Pujari ◽

Xiaoyan Chen ◽

...

Keyword(s):

Functional Polymers ◽

Polymer Chains ◽

New Materials ◽

Helical Structures ◽

Polymer Backbone ◽

Silyl Ethers ◽

Helical Polymer ◽

Key Characteristics ◽

Post Modification ◽

Individual Polymer

The first SuFEx click chemistry synthesis of SOF<sub>4</sub>-derived copolymers based upon the polymerization of bis(iminosulfur oxydifluorides) and bis(aryl silyl ethers) is described. This novel class of SuFEx polymer presents two key characteristics: First, the newly created [-N=S(=O)F-O-] polymer backbone linkages are themselves SuFExable and primed to undergo further high-yielding and precise SuFEx-based post-modification with phenols or amines to yield branched functional polymers. Second, studies of individual polymer chains of several of these new materials indicate the presence of helical polymer structures, which itself suggests a preferential approach of new monomers onto the growing polymer chain upon the formation of the stereogenic linking moiety.

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Dental 4D Printing: An Innovative Approach

10.30771/2018.4 ◽

2018 ◽

Author(s):

Hosamuddin Hamza

Keyword(s):

Innovative Approach ◽

4D Printing

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Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer

Case Medical Research ◽

10.31525/ct1-nct04218188 ◽

2020 ◽

Author(s):

Keyword(s):

Lung Cancer ◽

Prognostic Factor ◽

Cell Detachment ◽

Ph Responsive

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Faculty Opinions recommendation of Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727388654.793535445 ◽

2017 ◽

Cited By ~ 1

Author(s):

Timothy Cover

Keyword(s):

Helicobacter Pylori ◽

Chronic Infection ◽

Gastric Disease ◽

Ph Responsive

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Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

Current Medicinal Chemistry ◽

10.2174/0929867324666170406110642 ◽

2018 ◽

Vol 25 (25) ◽

pp. 3036-3057 ◽

Cited By ~ 6

Author(s):

Xiao Sun ◽

Guilong Zhang ◽

Zhengyan Wu

Keyword(s):

Drug Delivery ◽

Magnetic Resonance ◽

Drug Release ◽

Contrast Enhancement ◽

General Strategy ◽

Ph Responsive ◽

Physicochemical Changes ◽

Magnetic Resonance Contrast ◽

Resonance Contrast ◽

Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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