Nanomaterials combination for wound healing and skin regeneration

2020 ◽  
pp. 159-217
Author(s):  
Nowsheen Goonoo ◽  
Archana Bhaw-Luximon
Keyword(s):  
Wound Healing ◽  
Skin Regeneration

Wound Healing Microenvironmental Cues: From Tissue Analogs to Skin Regeneration

2013 ◽  
Vol 2 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Mariana Cerqueira ◽  
Rui Reis ◽  
Alexendra Marques
Keyword(s):  
Wound Healing ◽  
Skin Regeneration

scholarly journals Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10174-10175
Author(s):  
Chenggui Wang ◽  
Min Wang ◽  
Tianzhen Xu ◽  
Xingxing Zhang ◽  
Cai Lin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Regeneration ◽  
Self Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

Wound Healing and Skin Regeneration

2016 ◽  
pp. 17-25 ◽  
Author(s):  
Mihaela D. Leonida ◽  
Ish Kumar
Keyword(s):  
Wound Healing ◽  
Skin Regeneration

Integrin-binding pro-survival peptide engineered silk fibroin nanosheets for diabetic wound healing and skin regeneration

2020 ◽  
Vol 398 ◽  
pp. 125617
Author(s):  
Huishang Yang ◽  
Chen Lai ◽  
Chengkai Xuan ◽  
Muyuan Chai ◽  
Xuemin Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Skin Regeneration ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals A gelatin/collagen/polycaprolactone scaffold for skin regeneration

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6358 ◽  
Author(s):  
Lin-Gwei Wei ◽  
Hsin-I Chang ◽  
Yiwei Wang ◽  
Shan-hui Hsu ◽  
Lien-Guo Dai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Dermal Fibroblasts ◽  
Skin Regeneration ◽  
Collagen Content ◽  
Wound Dressings ◽  
Skin Substitute ◽  
Epidermal Keratinocytes ◽  
Adipose Derived Stem Cells

Background A tissue-engineered skin substitute, based on gelatin (“G”), collagen (“C”), and poly(ε-caprolactone) (PCL; “P”), was developed. Method G/C/P biocomposites were fabricated by impregnation of lyophilized gelatin/collagen (GC) mats with PCL solutions, followed by solvent evaporation. Two different GC:PCL ratios (1:8 and 1:20) were used. Results Differential scanning calorimetry revealed that all G/C/P biocomposites had characteristic melting point of PCL at around 60 °C. Scanning electron microscopy showed that all biocomposites had similar fibrous structures. Good cytocompatibility was present in all G/C/P biocomposites when incubated with primary human epidermal keratinocytes (PHEK), human dermal fibroblasts (PHDF) and human adipose-derived stem cells (ASCs) in vitro. All G/C/P biocomposites exhibited similar cell growth and mechanical characteristics in comparison with C/P biocomposites. G/C/P biocomposites with a lower collagen content showed better cell proliferation than those with a higher collagen content in vitro. Due to reasonable mechanical strength and biocompatibility in vitro, G/C/P with a lower content of collagen and a higher content of PCL (GCLPH) was selected for animal wound healing studies. According to our data, a significant promotion in wound healing and skin regeneration could be observed in GCLPH seeded with adipose-derived stem cells by Gomori’s trichrome staining. Conclusion This study may provide an effective and low-cost wound dressings to assist skin regeneration for clinical use.

Leucine-activated nanohybrid biofilm for skin regeneration via improving cell affinity and neovascularization capacity

2020 ◽  
Vol 8 (35) ◽  
pp. 7966-7976
Author(s):  
Xiajie Lin ◽  
Yamin Li ◽  
Wei Luo ◽  
Lan Xiao ◽  
Zeren Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amino Acid ◽  
Skin Regeneration ◽  
Cell Affinity ◽  
Nanofibrous Membranes

Nanohybrids containing amino acid are doped into biodegradable nanofibrous membranes, which improves the cell affinity, the migration and growth of fibroblasts, and the neovascularization capacity, comprehensively accelerating a rapid wound healing.

Injectable polysaccharide hybrid hydrogels as scaffolds for burn wound healing

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 94248-94256 ◽  
Author(s):  
Ziyi Li ◽  
Baoming Yuan ◽  
Xiaoming Dong ◽  
Lijie Duan ◽  
Huayu Tian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Schiff Base ◽  
Skin Regeneration ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Wound Model ◽  
Hybrid Hydrogels

In this study, the polysaccharide-based hydrogels were prepared by Schiff base reaction. Then, the hydrogels were applied to a burn wound model of rats, following by skin regeneration.

Zwitterionic hydrogels enhance angiogenic response, promote complete skin regeneration during full-thickness wound healing

2017 ◽  
Vol 259 ◽  
pp. e187-e188
Author(s):  
Zecong Xiao ◽  
Chaochao He ◽  
Jingjing Zhu ◽  
Jingjing Ye ◽  
Yi Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Regeneration ◽  
Full Thickness ◽  
Angiogenic Response ◽  
Full Thickness Wound

scholarly journals Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing

2021 ◽  
Vol 9 ◽  
Author(s):  
Mariliis Klaas ◽  
Kristina Mäemets-Allas ◽  
Elizabeth Heinmäe ◽  
Heli Lagus ◽  
Claudia Griselda Cárdenas-León ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Regeneration ◽  
Keratinocyte Proliferation ◽  
Fibroblast Migration ◽  
Extracellular Matrix Molecule ◽  
Primary Fibroblasts ◽  
And Migration ◽  
Thrombospondin 4

Thrombospondin-4 (THBS4) is a non-structural extracellular matrix molecule associated with tissue regeneration and a variety of pathological processes characterized by increased cell proliferation and migration. However, the mechanisms of how THBS4 regulates cell behavior as well as the pathways contributing to its effects have remained largely unexplored. In the present study we investigated the role of THBS4 in skin regeneration both in vitro and in vivo. We found that THBS4 expression was upregulated in the dermal compartment of healing skin wounds in humans as well as in mice. Application of recombinant THBS4 protein promoted cutaneous wound healing in mice and selectively stimulated migration of primary fibroblasts as well as proliferation of keratinocytes in vitro. By using a combined proteotranscriptomic pathway analysis approach we discovered that β-catenin acted as a hub for THBS4-dependent cell signaling and likely plays a key role in promoting its downstream effects. Our results suggest that THBS4 is an important contributor to wound healing and its incorporation into novel wound healing therapies may be a promising strategy for treatment of cutaneous wounds.

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