Environmentally relevant level of aflatoxin B1 and the role of (non)oxidative immuno-/neurodysregulation and toxicity

Toxicology ◽  
2021 ◽  
pp. 165-179
Author(s):  
Jalil Mehrzad
Keyword(s):  
Aflatoxin B1 ◽  
Relevant Level

Role of clay in detoxification of aflatoxin B1 in growing Japanese quail with reference to gender

2021 ◽  
Author(s):  
Khalid M. Mahrose ◽  
Izabela Michalak ◽  
Mohamed Farghly ◽  
Abdelmotaleb Elokil ◽  
Runxiang Zhang ◽  
...  
Keyword(s):  
Japanese Quail ◽  
Aflatoxin B1

Role of Lactone Ring in Structural, Electronic, and Reactivity Properties of Aflatoxin B1: A Theoretical Study

2010 ◽  
Vol 59 (3) ◽  
pp. 393-406 ◽  
Author(s):  
Inés Nicolás-Vázquez ◽  
Abraham Méndez-Albores ◽  
Ernesto Moreno-Martínez ◽  
René Miranda ◽  
Miguel Castro
Keyword(s):  
Aflatoxin B1 ◽  
Theoretical Study ◽  
Lactone Ring

Ameliorative role of ethanolic extract of Moringa oleifera leaf on aflatoxin B1-induced genotoxicity and biochemical alterations in rats

2018 ◽  
Vol 13 (1) ◽  
pp. 60 ◽  
Author(s):  
HasnaaA Radwan ◽  
IbrahimM Farag ◽  
HanaaM Roshdy ◽  
InasS Ghaly ◽  
SherifaH Salah ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Moringa Oleifera ◽  
Ethanolic Extract ◽  
Biochemical Alterations

The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1

2018 ◽  
Vol 156 ◽  
pp. 177-185 ◽  
Author(s):  
Haoran Jiang ◽  
Jun Wu ◽  
Feiyong Zhang ◽  
Jikai Wen ◽  
Jun Jiang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Aflatoxin B1 ◽  
Critical Role

Protective role of ascorbic acid to enhance semen quality of rabbits treated with sublethal doses of aflatoxin B1

Toxicology ◽  
2001 ◽  
Vol 162 (3) ◽  
pp. 209-218 ◽  
Author(s):  
M.H. Salem ◽  
K.I. Kamel ◽  
M.I. Yousef ◽  
G.A. Hassan ◽  
F.D. EL-Nouty
Keyword(s):  
Ascorbic Acid ◽  
Aflatoxin B1 ◽  
Semen Quality ◽  
Protective Role ◽  
Sublethal Doses

scholarly journals MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Yi-Xiao Liu ◽  
Xi-Dai Long ◽  
Zhi-Feng Xi ◽  
Yun Ma ◽  
Xiao-Ying Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Adducts ◽  
Aflatoxin B1 ◽  
Tissue Samples ◽  
Noncancerous Tissue ◽  
Free Survival ◽  
Tumor Tissues ◽  
Neoplastic Process ◽  
First Time

MicroRNA-24 (miR-24) may be involved in neoplastic process; however, the role of this microRNA in the hepatocellular carcinoma (HCC) related to aflatoxin B1 (AFB1) has not been well elaborated. Here, we tested miR-24 expression in 207 pathology-diagnosed HCC cases from high AFB1 exposure areas and HCC cells. We found that miR-24 was upregulated in HCC tumor tissues relative to adjacent noncancerous tissue samples, and that the high expression of miR-24 was significantly correlated with larger tumor size, higher microvessel density, and tumor dedifferentiation. Additionally, this microRNA overexpression modified the recurrence-free survival (relative hazard ratio [HR], 4.75; 95% confidence interval [CI], 2.66–8.47) and overall survival (HR=3.58, 95% CI = 2.34–5.46) of HCC patients. Furthermore, we observed some evidence of joint effects between miR-24 and AFB1 exposure on HCC prognosis. Functionally, miR-24 overexpression progressed tumor cells proliferation, inhibited cell apoptosis, and developed the formation of AFB1-DNA adducts. These results indicate for the first time that miR-24 may modify AFB1-related HCC prognosis and tumorigenesis.

scholarly journals Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Qingqiang Xu ◽  
Wenwen Shi ◽  
Pan Lv ◽  
Wenqi Meng ◽  
Guanchao Mao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Aflatoxin B1 ◽  
Cell Apoptosis ◽  
Critical Role ◽  
Hepatic Cell ◽  
Hepatocellular Injury ◽  
Caveolin 1 ◽  
Induced Apoptosis

AbstractAflatoxin B1 (AFB1) is a potent hepatocarcinogen in humans and exposure to AFB1 is known to cause both acute and chronic hepatocellular injury. As the liver is known to be the main target organ of aflatoxin, it is important to identify the key molecules that participate in AFB1-induced hepatotoxicity and to investigate their underlying mechanisms. In this study, the critical role of caveolin-1 in AFB1-induced hepatic cell apoptosis was examined. We found a decrease in cell viability and an increase in oxidation and apoptosis in human hepatocyte L02 cells after AFB1 exposure. In addition, the intracellular expression of caveolin-1 was increased in response to AFB1 treatment. Downregulation of caveolin-1 significantly alleviated AFB1-induced apoptosis and decreased cell viability, whereas overexpression of caveolin-1 reversed these effects. Further functional analysis showed that caveolin-1 participates in AFB1-induced oxidative stress through its interaction with Nrf2, leading to the downregulation of cellular antioxidant enzymes and the promotion of oxidative stress-induced apoptosis. In addition, caveolin-1 was found to regulate AFB1-induced autophagy. This finding was supported by the effect that caveolin-1 deficiency promoted autophagy after AFB1 treatment, leading to the inhibition of apoptosis, whereas overexpression of caveolin-1 inhibited autophagy and accelerated apoptosis. Interestingly, further investigation showed that caveolin-1 participates in AFB1-induced autophagy by regulating the EGFR/PI3K-AKT/mTOR signaling pathway. Taken together, our data reveal that caveolin-1 plays a crucial role in AFB1-induced hepatic cell apoptosis via the regulation of oxidation and autophagy, which provides a potential target for the development of novel treatments to combat AFB1 hepatotoxicity.

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