Therapeutic potency of bioactive compounds from fungal endophytes

This review describes examples of naturally occurring bioactive compounds obtained from fungal endophytes from various host plants. The main topics addressed are sources, identification, biological activity, biosynthesis, and ecological and chemosystematic significance of those bioactive compounds whose sources were well defined.

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The chemical composition, antifungal, antioxidant and antimutagenicity properties of bioactive compounds from fungal endophytes associated with Thai orchids

Journal of Phytopathology ◽

10.1111/jph.12773 ◽

2018 ◽

Vol 167 (1) ◽

pp. 56-64 ◽

Cited By ~ 7

Author(s):

Nattawadee Bungtongdee ◽

Kathawut Sopalun ◽

Wanpen Laosripaiboon ◽

Siriluck Iamtham

Keyword(s):

Chemical Composition ◽

Bioactive Compounds ◽

Fungal Endophytes

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Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds

Journal of Fungi ◽

10.3390/jof7100786 ◽

2021 ◽

Vol 7 (10) ◽

pp. 786

Author(s):

Martin Muthee Gakuubi ◽

Madhaiyan Munusamy ◽

Zhao-Xun Liang ◽

Siew Bee Ng

Keyword(s):

Bioactive Compounds ◽

Host Plants ◽

Communicable Disease ◽

Biological Activities ◽

Fungal Endophytes ◽

Gene Clusters ◽

New Drugs ◽

Biosynthetic Gene Clusters ◽

Fungal Isolation ◽

Non Communicable Disease

For years, fungi have served as repositories of bioactive secondary metabolites that form the backbone of many existing drugs. With the global rise in infections associated with antimicrobial resistance, in addition to the growing burden of non-communicable disease, such as cancer, diabetes and cardiovascular ailments, the demand for new drugs that can provide an improved therapeutic outcome has become the utmost priority. The exploration of microbes from understudied and specialized niches is one of the promising ways of discovering promising lead molecules for drug discovery. In recent years, a special class of plant-associated fungi, namely, fungal endophytes, have emerged as an important source of bioactive compounds with unique chemistry and interesting biological activities. The present review focuses on endophytic fungi and their classification, rationale for selection and prioritization of host plants for fungal isolation and examples of strategies that have been adopted to induce the activation of cryptic biosynthetic gene clusters to enhance the biosynthetic potential of fungal endophytes.

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Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

Journal of Fungi ◽

10.3390/jof7020147 ◽

2021 ◽

Vol 7 (2) ◽

pp. 147

Author(s):

Bartholomew Adeleke ◽

Olubukola Babalola

Keyword(s):

Medicinal Plants ◽

Bioactive Compounds ◽

Therapeutic Potential ◽

Fungal Endophytes ◽

New Drugs ◽

Bioactive Metabolites ◽

World Population ◽

Fungal Metabolites ◽

Human Needs ◽

Pharmacological Potential

Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential.

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Fungal endophytes: an alternative source of bioactive compounds for plant protection.

Natural products in plant pest management ◽

10.1079/9781845936716.0218 ◽

2010 ◽

pp. 218-241

Author(s):

R. N. Kharwar ◽

G. Strobel

Keyword(s):

Bioactive Compounds ◽

Plant Protection ◽

Fungal Endophytes ◽

Alternative Source

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Identification of Bioactive Coumarin(s) from Three Endophytic Fungal Species of Calophyllum tomentosum

The Natural Products Journal ◽

10.2174/2210315509666190430145906 ◽

2020 ◽

Vol 10 (4) ◽

pp. 502-512

Author(s):

Channabasava ◽

Govindappa Melappa

Keyword(s):

Bioactive Compounds ◽

Methanol Extract ◽

Fusarium Species ◽

Fungal Endophytes ◽

Fungal Species ◽

Hexane Extract ◽

Coumaric Acid ◽

Alternaria Species ◽

Different Parts

Background: Many biologically important bioactive compounds have been identified in Calophyllum tomentosum extract. Hence, we aimed to identify different endophytic fungal species from different parts of the plants and their bioactive compounds. Objective: The study includes identification and characterization of bioactive compounds in the extracts of endophytic fungal species of Calophyllum tomentosum. Methods: Different parts were used to assess the different endophytic fungi. Two different solvents were used: extracts and qualitative solvents. TLC and GC-MS were employed to identify the bioactive compounds. The bioactive compounds producing endophytes were identified by using18S rRNA. Results: In total, 13 different fungal species were identified from different parts of the Calophyllum tomentosum. The C. tomentosum leaf part showed seven different fungal endophytes from the barks (four) and stems (two). The methanol extract of Fusarium species (stem), Cladosporium species (bark) and hexane extract of Alternaria species (bark) showed a higher amount of coumarins in qualitative methods and TLC. Based on the above results, for further GC-MS and molecular identification studies, we selected three endophytes. In the GC-MS analysis, the methanol extract of Fusarium species (stem) showed psoralen, and furocoumarin (imperatonin or ammidin); Cladosporium species (bark) showed coumarin (2H-1-benzopyran-2-one), coumaric acid (3-benzofurancarboxylic acid), hynecromone (coumarin 4), 4-hydroxy-9-(3-methyl-2-butyl)furo(3,2-g)chloronen-7- one; and hexane extract of Alternaria species (bark) showed coumaric acid (3-benzofurancarboxylic acid). The three fungal endophytes were identified as Fusarium equiseti, Cladosporium uredinicola and Alternaria alternata from 18S rRNA analysis. Conclusions: Based on the above results, the three endophytic fungal species confirm the presence of coumarins and therefore, can be used for the production of coumarins instead of the plant.

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