Surface-enhanced Raman spectroscopy-based microfluidic devices for in vitro diagnostics

2022 ◽  
pp. 281-302
Author(s):  
Anupam Das ◽  
Jaebum Choo
Keyword(s):  
Raman Spectroscopy ◽  
Microfluidic Devices ◽  
Surface Enhanced Raman Spectroscopy ◽  
In Vitro Diagnostics ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

Surface-enhanced Raman spectroscopy of DNA from leaves of in vitro grown apple plants

2010 ◽  
Vol 42 (4) ◽  
pp. 844-850 ◽  
Author(s):  
Cristina M. Muntean ◽  
Nicolae Leopold ◽  
Adela Halmagyi ◽  
Sergiu Valimareanu
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

Nanophotonics ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 681-701 ◽  
Author(s):  
Haley Marks ◽  
Monika Schechinger ◽  
Javier Garza ◽  
Andrea Locke ◽  
Gerard Coté
Keyword(s):  
Raman Spectroscopy ◽  
Point Of Care ◽  
Low Cost ◽  
Diagnostic Testing ◽  
Surface Enhanced Raman Spectroscopy ◽  
World Health ◽  
Great Promise ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

AbstractPoint-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, self-contained, and can be used anywhere – from modern clinics to remote and low resource areas. In this review, surface enhanced Raman spectroscopy (SERS) is discussed as a solution to facilitating the translation of bioanalytical sensing to the POC. The potential for SERS to meet the widely accepted “ASSURED” (Affordable, Sensitive, Specific, User-friendly, Rapid, Equipment-free, and Deliverable) criterion provided by the World Health Organization is discussed based on recent advances in SERS in vitro assay development. As SERS provides attractive characteristics for multiplexed sensing at low concentration limits with a high degree of specificity, it holds great promise for enhancing current efforts in rapid diagnostic testing. In outlining the progression of SERS techniques over the past years combined with recent developments in smart nanomaterials, high-throughput microfluidics, and low-cost paper diagnostics, an extensive number of new possibilities show potential for translating SERS biosensors to the POC.

scholarly journals Identification and Analysis of Exosomes by Surface-Enhanced Raman Spectroscopy

2019 ◽  
Vol 9 (6) ◽  
pp. 1135 ◽  
Author(s):  
Anastasiia Merdalimova ◽  
Vasiliy Chernyshev ◽  
Daniil Nozdriukhin ◽  
Polina Rudakovskaya ◽  
Dmitry Gorin ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
High Efficiency ◽  
High Sensitivity ◽  
Cancer Biomarkers ◽  
Surface Enhanced Raman Spectroscopy ◽  
Circulating Tumor Dna ◽  
Novel Approach ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

The concept of liquid biopsy has emerged as a novel approach for cancer screening, which is based on the analysis of circulating cancer biomarkers in body fluids. Among the various circulating cancer biomarkers, including Food and Drug Administration (FDA)-approved circulating tumor cells (CTC) and circulating tumor DNA (ctDNA), exosomes have attracted tremendous attention due to their ability to diagnose cancer in its early stages with high efficiency. Recently, surface-enhanced Raman spectroscopy (SERS) has been applied for the detection of cancer exosomes due to its high sensitivity, specificity, and multiplexing capability. In this article, we review recent progress in the development of SERS-based technologies for in vitro identification of circulating cancer exosomes. The accent is made on the detection strategies and interpretation of the SERS data. The problems of detecting cancer-derived exosomes from patient samples and future perspectives of SERS-based diagnostics are also discussed.

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