Spirulina is one of the most highly-demanded and popular dietary supplements in the world. It is widely used in healthy nutrition both as a colorant and as a nutrient additive containing a large number of useful trace elements and vitamins. Spirulina is also used to create photosensitizers for photodynamic therapy, which is used to treat cancer and other diseases. Our objective was to conduct experiments and evaluate the eff ect of Spirulina solutions on the histological characteristics of Danio rerio organs. We tested the eff ect of Spirulina on adult fi sh Danio rerio in an acute 96-hour experiment at concentrations of: 0,1; 1,0, 10,0; 30,0; 100,0 mg/l. Afterwards, the histological micro-preparations obtained from the liver, intestines, kidneys, ovaries, and gills of the striped Danio were examined. The studies of the preparations have shown that the maximum allowable concentration of Spirulina solution for fi sh is 3 mg/l. These data can be used in hydrobiology for water disinfection methods, in ichthyopathology for fi sh treatment, and in food industry toxicology. Therefore, when using it for disinfection of water in the reservoir, aquatic invertebrates and fi sh will not be aff ected and sharp changes in the biocenosis of the reservoir are not expected.