Comparison of cardiotoxicity between N-methyl-glucamine and miltefosine in the treatment of American cutaneous leishmaniasis

We reviewed the records of 151 patients diagnosed with American cutaneous leishmaniasis (ACL) from 1993 to 2009 in the municipality of Japura, Paraná, Brazil. Gender, age, occupation, place of residence, location of lesions, type and number of lesions were analyzed. The prevalence rate of ACL was 11.5/10,000 hab, of which 84.7% were male, 58.3% lived in rural area and 49.0% were farmers. The most frequent age group was between 30 to 39 years (26.6%). Skin lesions occurred in 92.7% of the patients with predominance in the lower limbs (23.9%) and 49.1% of the records did not include the number of lesions location due to incomplete filling. A single ulceration was present in 44.4%. Japurá is an endemic area for ACL, requiring public actions and preventive education.

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Topical Paromomycin/Methylbenzethonium Chloride Plus Parenteral Meglumine Antimonate as Treatment for American Cutaneous Leishmaniasis: Controlled Study

Clinical Infectious Diseases ◽

10.1086/516267 ◽

1998 ◽

Vol 26 (1) ◽

pp. 56-58 ◽

Cited By ~ 57

Author(s):

J. Soto ◽

P. Fuya ◽

R. Herrera ◽

J. Berman

Keyword(s):

Cutaneous Leishmaniasis ◽

Controlled Study ◽

American Cutaneous Leishmaniasis

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A serological and molecular investigation of American cutaneous leishmaniasis in dogs, three years after an outbreak in the Northwest of Paraná State, Brazil

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2009000100010 ◽

2009 ◽

Vol 25 (1) ◽

pp. 97-104 ◽

Cited By ~ 11

Author(s):

Gustavo Kiyoshi Massunari ◽

Evandra Maria Voltarelli ◽

Demilson Rodrigues dos Santos ◽

Ademar Rodrigues dos Santos ◽

Luiz Paschoal Poiani ◽

...

Keyword(s):

Bone Marrow ◽

Cutaneous Leishmaniasis ◽

Control Measures ◽

Transmission Control ◽

Chain Reaction ◽

American Cutaneous Leishmaniasis ◽

Molecular Investigation ◽

Polymerase Chain ◽

Pcr Techniques

Classic and molecular (polymerase chain reaction - PCR) techniques were used to diagnose American cutaneous leishmaniasis in 149 dogs from an area in the northwest of Paraná State, Brazil, where an American cutaneous leishmaniasis outbreak occurred in 2002. The results were compared to a set of previously obtained results. Twenty-five dogs had positive indirect immunofluorescence (IIF) (titers > 40), including two animals with suggestive lesions. The percentage of dogs with positive IIF was similar to that found in a previous study. The cultures of the lesion, blood and bone marrow were negative for Leishmania. A direct search for the parasite in the lesions proved negative, although PCR tests were positive. The PCR did not detect the DNA of Leishmania (Viannia) in the blood, even for those that had positive PCR in a previous study. The follow up of the 27 dogs showed that the majority of them had maintained the same levels of antibodies that had been detected previously. There was a reduction in the number of dogs with lesions, probably due to the transmission control measures that were adopted after the outbreak.

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