Thiol-ene microfluidic chip for fast on-chip sample clean-up, separation and ESI mass spectrometry of peptides and proteins

2020 ◽  
Vol 1140 ◽  
pp. 168-177
Author(s):  
Rasmus R. Svejdal ◽  
Drago Sticker ◽  
Claus Sønderby ◽  
Jörg P. Kutter ◽  
Kasper D. Rand
Keyword(s):  
Mass Spectrometry ◽  
Microfluidic Chip ◽  
Chip Sample ◽  
Esi Mass Spectrometry ◽  
On Chip

scholarly journals (2S,3R,6R)-2-[(R)-1-Hydroxyallyl]-4,4-dimethoxy-6-methyltetrahydro-2H-pyran-3-ol

Molbank ◽  
10.3390/m1140 ◽  
2020 ◽  
Vol 2020 (2) ◽  
pp. M1140
Author(s):  
Jack Bennett ◽  
Paul Murphy
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Ir Spectroscopy ◽  
13C Nmr ◽  
Conjugate Addition ◽  
13C Nmr Spectroscopy ◽  
One Pot ◽  
1H And 13C Nmr ◽  
Esi Mass Spectrometry ◽  
The One

(2S,3R,6R)-2-[(R)-1-Hydroxyallyl]-4,4-dimethoxy-6-methyltetrahydro-2H-pyran-3-ol was isolated in 18% after treating the glucose derived (5R,6S,7R)-5,6,7-tris[(triethylsilyl)oxy]nona-1,8-dien-4-one with (1S)-(+)-10-camphorsulfonic acid (CSA). The one-pot formation of the title compound involved triethylsilyl (TES) removal, alkene isomerization, intramolecular conjugate addition and ketal formation. The compound was characterized by 1H and 13C NMR spectroscopy, ESI mass spectrometry and IR spectroscopy. NMR spectroscopy was used to establish the product structure, including the conformation of its tetrahydropyran ring.

Localization ofo-glycosylation sites of MUC1 tandem repeats by QTOF ESI mass spectrometry

1998 ◽  
Vol 33 (4) ◽  
pp. 358-362 ◽  
Author(s):  
Franz-Georg Hanisch ◽  
Brian N. Green ◽  
Robert Bateman ◽  
Jasna Peter-Katalinic
Keyword(s):  
Mass Spectrometry ◽  
Tandem Repeats ◽  
Glycosylation Sites ◽  
Esi Mass Spectrometry

On-chip cavity-enhanced absorption spectroscopy using a white light-emitting diode and polymer mirrors

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 711-717 ◽  
Author(s):  
Cathy M. Rushworth ◽  
Gareth Jones ◽  
Martin Fischlechner ◽  
Emma Walton ◽  
Hywel Morgan
Keyword(s):  
Absorption Spectroscopy ◽  
White Light ◽  
Microfluidic Chip ◽  
Path Length ◽  
Light Emitting Diode ◽  
Absorption Path Length ◽  
Light Emitting ◽  
Enhanced Absorption ◽  
Cavity Enhanced Absorption Spectroscopy ◽  
On Chip

We have integrated disposable polymer mirrors within a microfluidic chip to form a multi-pass cell, which increases the absorption path length by a maximum of 28 times, providing micromolar detection limits in a probed volume of 10 nL.

scholarly journals Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Yan Zhang ◽  
Sungho Kim ◽  
Weihua Shi ◽  
Yaoyao Zhao ◽  
Insu Park ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Phase Separation ◽  
Electrospray Ionization ◽  
Mass Spectrometry Analysis ◽  
Microfluidic Channels ◽  
Droplet Generator ◽  
Microfluidic Platform ◽  
Spectrometry Analysis ◽  
Temporal Phase ◽  
On Chip

We report on a silicon microfluidic platform that enables integration of transparent μm-scale microfluidic channels, an on-chip pL-volume droplet generator, and a nano-electrospray ionization emitter that enables spatial and temporal phase separation for mass spectrometry analysis.

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