Spectral CT Imaging of Lung Cancer

Background: This study proposed to quantitatively assess the value of spectral CT imaging parameters in differentiating different pathological types of lung cancer. Methods: Eighty five patients with lung cancer (66 non-mucinous adenocarcinomas, 7 Squamous cell carcinomas, 8 small cell carcinomas, 1 mucinous adenocarcinoma, 1 sarcomatoid carcinoma, 1 carcinoid, 1 large cell carcinoma) underwent CT plain scan, contrast enhanced CT scans in arterial phase (a) and venous phase (v) with spectral imaging mode on a GE Revolution Xtream CT scanner. The Spectral CT Imaging parameters: Iodine concentrations (IC) of lesion in arterial phase (ICLa) and venous phase (ICLv), Normalized IC (NICa/NICv)-normalized to the IC in the aorta, slope of the spectral HU curve (λHUa/λHUv) and monochromatic CT number (CT40keVa/CT40keVv, CT70keVa/CT70keVv) enhancement on 40 keV and 70 keV images were calculated. The One-way ANOVA or Kruskal-Wallis test was used to compare quantitative parameters among lung squamous carcinoma, small cell carcinoma and lung adenocarcinoma groups, Bonferroni method was used to correct P value for multiple comparisons. Results: Among the different pathological types of lung cancers, these quantitative parameters of spectral CT imaging CT70keVa has significant difference. The CT70keVa of lung adenocarcinoma was lower than small cell carcinoma (P = 0.048) and squamous cell carcinoma (P = 0.039), respectively. And these CT40keVa, CT70keVa/CT70keVv parameters of lung adenocarcinoma was lower than non-adenocarcinomas (P < 0.05). However, there was no significant difference in spectral CT parameters between small cell lung cancer and squamous cell lung cancer, small cell lung cancer and non-small cell carcinoma (P > 0.05). Conclusion: Spectral CT parameters may be of value in distinguishing different pathological types of lung cancer.

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Differential diagnosis of osteoblastic metastases from bone islands in patients with lung cancer by single-source dual-energy CT: Advantages of spectral CT imaging

European Journal of Radiology ◽

10.1016/j.ejrad.2015.01.007 ◽

2015 ◽

Vol 84 (5) ◽

pp. 901-907 ◽

Cited By ~ 26

Author(s):

Yue Dong ◽

Shaowei Zheng ◽

Haruhiko Machida ◽

Bing Wang ◽

Ailian Liu ◽

...

Keyword(s):

Lung Cancer ◽

Differential Diagnosis ◽

Dual Energy ◽

Ct Imaging ◽

Dual Energy Ct ◽

Single Source ◽

Spectral Ct

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PET/CT Imaging of Small Cell Lung Cancer Using 89Zr-DFO-SC16.56

Case Medical Research ◽

10.31525/ct1-nct04199741 ◽

2019 ◽

Author(s):

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Ct Imaging ◽

Small Cell ◽

Small Cell Lung ◽

Pet Ct

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Automating Lung Cancer Identification in PET/CT Imaging

2018 IEEE 4th International Forum on Research and Technology for Society and Industry (RTSI) ◽

10.1109/rtsi.2018.8548388 ◽

2018 ◽

Author(s):

E. D'Arnese ◽

E. Del Sozzo ◽

A. Chiti ◽

T. Berger-Wolf ◽

M. D. Santambrogio

Keyword(s):

Lung Cancer ◽

Ct Imaging ◽

Pet Ct

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Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases

Diagnostics ◽

10.3390/diagnostics11112075 ◽

2021 ◽

Vol 11 (11) ◽

pp. 2075

Author(s):

Andreana Bompoti ◽

Andreas S. Papazoglou ◽

Dimitrios V. Moysidis ◽

Nikolaos Otountzidis ◽

Efstratios Karagiannidis ◽

...

Keyword(s):

Lung Cancer ◽

Lung Tissue ◽

Lung Diseases ◽

Human Lung ◽

Imaging Modality ◽

Clinical Applications ◽

Ct Imaging ◽

Micro Ct ◽

Volumetric Imaging ◽

Scoping Reviews

Micro-computed tomography (micro-CT) is a promising novel medical imaging modality that allows for non-destructive volumetric imaging of surgical tissue specimens at high spatial resolution. The aim of this study is to provide a comprehensive assessment of the clinical applications of micro-CT for the tissue-based diagnosis of lung diseases. This scoping review was conducted in accordance with the PRISMA Extension for Scoping Reviews, aiming to include every clinical study reporting on micro-CT imaging of human lung tissues. A literature search yielded 570 candidate articles, out of which 37 were finally included in the review. Of the selected studies, 9 studies explored via micro-CT imaging the morphology and anatomy of normal human lung tissue; 21 studies investigated microanatomic pulmonary alterations due to obstructive or restrictive lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and cystic fibrosis; and 7 studies examined the utility of micro-CT imaging in assessing lung cancer lesions (n = 4) or in transplantation-related pulmonary alterations (n = 3). The selected studies reported that micro-CT could successfully detect several lung diseases providing three-dimensional images of greater detail and resolution than routine optical slide microscopy, and could additionally provide valuable volumetric insight in both restrictive and obstructive lung diseases. In conclusion, micro-CT-based volumetric measurements and qualitative evaluations of pulmonary tissue structures can be utilized for the clinical management of a variety of lung diseases. With micro-CT devices becoming more accessible, the technology has the potential to establish itself as a core diagnostic imaging modality in pathology and to enable integrated histopathologic and radiologic assessment of lung cancer and other lung diseases.

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Dynamic PET/CT Imaging of 68Ga-FAPI-04 in Chinese Subjects

Frontiers in Oncology ◽

10.3389/fonc.2021.651005 ◽

2021 ◽

Vol 11 ◽

Author(s):

Shuailiang Wang ◽

Xin Zhou ◽

Xiaoxia Xu ◽

Jin Ding ◽

Teli Liu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Body Mass ◽

Fdg Pet ◽

Radiation Dosimetry ◽

Ct Imaging ◽

Lung Cancer Patients ◽

Pet Ct ◽

Fdg Pet Ct ◽

Chinese Subjects

This study aims to further explore dynamic 68Ga-FAPI-04 PET/CT imaging of healthy Chinese subjects and lung cancer patients. Moreover, the variability of 68Ga-FAPI-04 uptake in normal organs was measured to provide a basis for analyzing its biological distribution, interpreting auxiliary images, determining the reliability of image quantification, and monitoring treatment. Six patients (3 subjects without tumors and 3 lung cancer patients) separately underwent 68Ga-FAPI-04 and 2-[18F]FDG PET/CT imaging within 1 week. The biodistribution and internal radiation dosimetry were reported and compared with data previously obtained from Caucasian patients. Moreover, the mean SUV (standardized uptake value) was normalized to body mass or to lean body mass (SUL), and the coefficients of variation (CVs) were calculated and compared for each volume of interest. The average whole-body effective dose was calculated to be 1.27E-02 mSv/MBq, which was comparable with previously reported results of 68Ga-FAPI-04 probes. Furthermore, the SUVmean was slightly higher than the SULmean in most organs; however, the CV of the SULmean for most organs was higher than that of the SUVmean at later time points. In the liver, the CV of the SUVmean was lower (12.7%) than that of the SULmean and was similar to the CV for corresponding 2-[18F]FDG PET/CT value (11.8%). In addition, 68Ga-FAPI-04 PET/CT showed good efficacy for diagnosing lung cancer patients in this study. A comparison of the radiation dosimetry obtained before from a Caucasian population demonstrated no clinically significant differences between these two populations after 68Ga-FAPI-04 injection. The variability in most organs was slightly lower for SUVmean than for SULmean, suggesting that SUVmean may be the preferable parameter for quantifying images obtained with 68Ga-FAPI-04. In addition, 68Ga-FAPI-04 PET/CT imaging is expected to be a promising tool for diagnosing lung cancer.

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PET/CT imaging in lung cancer: indications and findings

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37132015000004479 ◽

2015 ◽

Vol 41 (3) ◽

pp. 264-274 ◽

Cited By ~ 26

Author(s):

Bruno Hochhegger ◽

Giordano Rafael Tronco Alves ◽

Klaus Loureiro Irion ◽

Carlos Cezar Fritscher ◽

Leandro Genehr Fritscher ◽

...

Keyword(s):

Lung Cancer ◽

Pulmonary Nodules ◽

Cancer Staging ◽

Ct Imaging ◽

Inappropriate Treatment ◽

Pet Ct ◽

Disease Staging ◽

Anatomical Information ◽

Work Up

The use of PET/CT imaging in the work-up and management of patients with lung cancer has greatly increased in recent decades. The ability to combine functional and anatomical information has equipped PET/CT to look into various aspects of lung cancer, allowing more precise disease staging and providing useful data during the characterization of indeterminate pulmonary nodules. In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer. However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders. Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment. This review article aimed to summarize the basic principles, indications, cancer staging considerations, and future applications related to the use of PET/CT in lung cancer.

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