Simulation applicability verification of various slip models in micro-nozzle

2021 ◽  
Author(s):  
Xinjie Li ◽  
Junya Yuan ◽  
Xiang Ren ◽  
Guobiao Cai
Keyword(s):  
Micro Nozzle

Size control of calcium alginate beads containing living cells using micro-nozzle array

Biomaterials ◽  
2005 ◽  
Vol 26 (16) ◽  
pp. 3327-3331 ◽  
Author(s):  
Shinji Sugiura ◽  
Tatsuya Oda ◽  
Yasuhiko Izumida ◽  
Yasuyuki Aoyagi ◽  
Mitsuo Satake ◽  
...  
Keyword(s):  
Calcium Alginate ◽  
Size Control ◽  
Alginate Beads ◽  
Living Cells ◽  
Calcium Alginate Beads ◽  
Micro Nozzle

Coupled solid (FVM)–fluid (DSMC) simulation of micro-nozzle with unstructured-grid

2009 ◽  
Vol 7 (5) ◽  
pp. 621-631 ◽  
Author(s):  
Zhi-Xin Sun ◽  
Zeng-Yao Li ◽  
Ya-Ling He ◽  
Wen-Quan Tao
Keyword(s):  
Unstructured Grid ◽  
Micro Nozzle ◽  
Dsmc Simulation

scholarly journals Establishment of a Mouse Ovarian Cancer and Peritoneal Metastasis Model to Study Intraperitoneal Chemotherapy

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3818
Author(s):  
Günther A. Rezniczek ◽  
Jonathan Buggisch ◽  
Julien Sobilo ◽  
Alexandre Launay ◽  
Stéphanie Lerondel ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Mouse Model ◽  
Intraperitoneal Chemotherapy ◽  
Ex Vivo ◽  
Delivery Mode ◽  
Micro Nozzle ◽  
Skov3 Cells ◽  
Tumor Load ◽  
Metastasis Model ◽  
Median Diameter

Intraperitoneal chemotherapy (IPC) is a locoregional treatment option in patients with peritoneal metastases (PM). Here, we present an ovarian cancer (OC)-derived PM mouse model for the study of different forms of IPC. Xenograft cell proliferation (luciferase-transfected OVCAR3 and SKOV3 clones) and growth kinetics were assessed using PET scan, bioluminescence imaging (BLI), and histological tumor analysis. Liquid IPC was achieved by intraperitoneal injection with/without capnoperitoneum (6–7 mmHg). Pressurized intraperitoneal aerosol chemotherapy (PIPAC) was mimicked using an intratracheal drug aerosol administration system (micro-nozzle), which, as demonstrated by ex vivo granulometric analysis using laser diffraction spectrometry, produced a polydisperse, bimodal aerosol with a volume-weighted median diameter of (26.49 ± 2.76) µm. Distribution of Tc-99m-labeled doxorubicin in mice was characterized using SPECT and was dependent on the delivery mode and most homogeneous when the micro-nozzle was used. A total of 2 mg doxorubicin per kg body weight was determined to be the optimally effective and tolerable dose to achieve at least 50% tumor reduction. Repeated PIPAC (four times at seven-day-intervals) with doxorubicin in SKOV3-luc tumor-bearing mice resulted in halted tumor proliferation and tumor load reduced after the second round of PIPAC versus controls and the number of tumor nodules was significantly reduced (27.7 ± 9.5 vs. 57.3 ± 9.5; p = 0.0003). Thus, we established the first mouse model of OC PM for the study of IPC using a human xenograft with SKOV3 cells and an experimental IPC setup with a miniaturized nozzle. Repeated IPC was feasible and demonstrated time-dependent anti-tumor activity.

Numerical Simulation of Fluid Flow and Heat Transfer in the Micro-Nozzle

2005 ◽  
Author(s):  
Longjian Li ◽  
Yihua Zhang ◽  
Wenzhi Cui ◽  
Tien-Chien Jen ◽  
Qinghua Chen ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Control Volume ◽  
Slip Model ◽  
Control Volume Method ◽  
Propulsion Performance ◽  
Micro Nozzle ◽  
Flow And Heat Transfer ◽  
Finite Control ◽  
Mems Technology ◽  
Volume Method

Micro-nozzle, based on the MEMS technology, has played an important role in orbit positioning, attitude adjusting and other applications of micro-satellites. The continuous no-slip model of two-dimensional compressible laminar flow in the micro-nozzle was proposed and solved numerically by finite control volume method. The flow and heat transfer in the micro-nozzle were computed under different conditions, including different inlet pressures, different inlet temperatures and different divergent angles. Flow field and effects of these conditions on the propulsion performance were analyzed. Finally, simulated solutions were compared and validated with the experimental results.

A Study of the Fabrication and Analysis of Micro Diffuser/Nozzles

2003 ◽  
Author(s):  
Kai-Shing Yang ◽  
Ing-Young Chen ◽  
Bor-Yuan Shew ◽  
Chi-Chuan Wang
Keyword(s):  
Reynolds Number ◽  
Friction Factor ◽  
Pressure Loss ◽  
Measured Data ◽  
Loss Coefficient ◽  
Opening Angle ◽  
Velocity Change ◽  
Pressure Loss Coefficient ◽  
Micro Nozzle ◽  
Volumetric Flowrate

In this study, an analysis of the performance of micro nozzle/diffusers is performed and fabrication of the micro nozzle/diffuser is conducted and tested. It is found that the pressure loss coefficient for the nozzle/diffuser decreases with the Reynolds number. At a given Reynolds number, the pressure loss coefficient for nozzle is higher than that of the diffuser due to considerable difference in the momentum change. For the effect of nozzle/diffuser length on the pressure loss coefficient, it is found that the influence is rather small. At a fixed volumetric flowrate, a “minimum” phenomenon of the pressure loss coefficient vs. nozzle/diffuser depth is encountered. This is related to the interactions of velocity change and friction factor. Good agreements of the measured data with the predicted results are found in this study except at a diffuser having an opening angle of 20° . It is likely that the departure of this case to the prediction is due to the separation phenomenon in a larger angle of the diffuser.

scholarly journals Horn Geometry Effects on Atomization Characteristics of a Micro Nozzle Array Type Ultrasonic Fuel Injector

2008 ◽  
Vol 74 (737) ◽  
pp. 228-236
Author(s):  
Mikiya ARAKI ◽  
Tomio OBOKATA ◽  
Tsuneaki ISHIMA ◽  
Seiichi SHIGA ◽  
Masahiko MASUBUCHI ◽  
...  
Keyword(s):  
Fuel Injector ◽  
Array Type ◽  
Micro Nozzle ◽  
Geometry Effects ◽  
Atomization Characteristics
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