scholarly journals A new marker to predict incident atrial fibrillation: Change in left atrioventricular coupling index. Report from the Multi-Ethnic Study of Atherosclerosis (MESA)

2022 ◽  
Vol 14 (1) ◽  
pp. 87-88
Author(s):  
T. Pezel ◽  
B.A. Venkatesh ◽  
T. Quinaglia ◽  
S.R. Heckbert ◽  
Y. Kato ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ethnic Study ◽  
Coupling Index

scholarly journals Change in left atrioventricular coupling index to predict incident atrial fibrillation: the multi-ethnic study of atherosclerosis (MESA)

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
T Pezel ◽  
B Ambale Venkatesh ◽  
T Quinaglia ◽  
S Heckbert ◽  
YOKO Kato ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Prognostic Value ◽  
Discrimination Performance ◽  
Left Ventricular ◽  
Ethnic Population ◽  
Ethnic Study ◽  
C Statistic ◽  
Coupling Index ◽  
Traditional Risk Factors

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Left atrial (LA) and left ventricular (LV) structural and functional parameters have independent prognostic values as predictors of atrial fibrillation (AF). PURPOSE Due to the intrinsic physiological relationship between LA and LV, we sought to investigate the prognostic value of a left atrioventricular coupling index (LACI) as well as change in LACI to predict incident AF in a multi-ethnic population. METHODS In the Multi-Ethnic Study of Atherosclerosis (MESA), 1,911 study participants, free of clinically recognized AF and cardiovascular disease at baseline, had LACI assessed with CMR imaging at baseline (Exam 1, 2000–2002), and ten years later (Exam 5, 2010–2012). LACI was defined as the ratio of LA to LV end-diastolic volumes. Univariable and multivariable Cox proportional hazard models were used to evaluate the associations of LACI and average annualized change in LACI (ΔLACI) with incident AF. RESULTS Among the 1,911 participants (mean age 59 ± 9 years and 47.5% male participants), 87 incident AF events occurred over 3.9 ±0.9 years following the second imaging (Exam 5). After adjustment for traditional risk factors, greater LACI and ΔLACI were independently associated with AF (HR 1.69, 95% CI [1.46-1.96] and HR 1.71, 95% CI [1.50-1.94], respectively; both p < 0.0001). Adjusted models for LACI and ΔLACI showed significant improvement in model discrimination compared to currently used AF risk score model for predicting AF incidence (C-statistic: 0.78 vs. 0.74, and C-statistic: 0.80 vs. 0.74, respectively). The LACI and ΔLACI also showed superior discrimination performance for AF compared to the multivariable model including CHARGE-AF score, and individual LA or LV parameters. CONCLUSIONS Atrioventricular coupling (LACI) and coupling change (ΔLACI) are strong predictors for AF incidence in a multi-ethnic population. Both have incremental prognostic value for predicting AF over traditional risk factors, and superior discrimination power compared to the CHARGE-AF score and to individual LA or LV parameters.

scholarly journals Change in left atrioventricular coupling index to predict incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA)

2021 ◽  
Vol 13 (3) ◽  
pp. 239-240
Author(s):  
T. Pezel ◽  
B. Ambale Venkatesh ◽  
T. Quinaglia ◽  
S.R. Heckbert ◽  
Y. Kato ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ethnic Study ◽  
Coupling Index

scholarly journals Relation of Physical Activity and Incident Atrial Fibrillation (from the Multi-Ethnic Study of Atherosclerosis)

2015 ◽  
Vol 116 (6) ◽  
pp. 883-888 ◽  
Author(s):  
Aneesh Bapat ◽  
Yiyi Zhang ◽  
Wendy S. Post ◽  
Eliseo Guallar ◽  
Elsayed Z. Soliman ◽  
...  
Keyword(s):  
Physical Activity ◽  
Atrial Fibrillation ◽  
Ethnic Study

Abstract MP60: Depressive Symptoms and Risk of Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Parveen K Garg ◽  
Wesley T O'Neal ◽  
Ana V Diez Roux ◽  
Alvaro Alonso ◽  
Elsayed Soliman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Depressive Symptoms ◽  
Proportional Hazards ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Cox Proportional Hazards ◽  
Fee For Service ◽  
Score Distribution ◽  
Ethnic Study ◽  
Increased Risk

Background: Depression has been suggested as a potential risk factor for atrial fibrillation (AF) through effects on the autonomic nervous system and hypothalamus-pituitary-adrenal axis. Current literature examining the prospective relationship between depression and AF is inconsistent and limited to studies performed in predominantly white populations. We determined the relationship of both depressive symptoms and anti-depressant use with incident AF in a multi-ethnic cohort. Methods: The Multi-Ethnic Study of Atherosclerosis is a prospective study of 6,814 individuals without clinical cardiovascular disease. Depressive symptoms were assessed at baseline by the 20-item Center for Epidemiologic Studies Depression Scale (CES-D) and use of anti-depressant medications. Five CES-D groups were created based on the score distribution in approximate quartiles, and the top quartile split in 2 such that the top group represented persons with a score ≥16, a value commonly used to identify clinically relevant symptoms. Incident AF was identified from study ECGs verified for AF, ICD-9 hospital discharge diagnoses consistent with AF, and, for participants enrolled in fee-for-service Medicare, inpatient and outpatient AF claims data. Results: 6,644 participants (mean age=62; 53% women; 38% white; 28% black; 22% Hispanic; 12% Chinese-American) were included and followed for a median of 13 years. In separate adjusted Cox proportional hazards analyses, a CES-D≥16 (referent=CES-D<2) and anti-depressant use were each associated with higher incidence of AF (Table). Associations did not differ by race or gender (interaction p-values of 0.18 and 0.17 respectively). Similar results were obtained using time-updated measures of depression. Conclusions: Depressive symptoms are associated with an increased risk of incident AF. Further study into whether improving depressive symptoms reduces AF incidence is important.

scholarly journals Ability of Reduced Lung Function to Predict Development of Atrial Fibrillation in Persons Aged 45 to 84 Years (from the Multi-Ethnic Study of Atherosclerosis-Lung Study)

2015 ◽  
Vol 115 (12) ◽  
pp. 1700-1704 ◽  
Author(s):  
Harjit Chahal ◽  
Susan R. Heckbert ◽  
R. Graham Barr ◽  
David A. Bluemke ◽  
Aditya Jain ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Lung Function ◽  
Ethnic Study

scholarly journals The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis

2018 ◽  
Vol 269 ◽  
pp. 86-91 ◽  
Author(s):  
Tsz Him Hui ◽  
Robyn L. McClelland ◽  
Matthew A. Allison ◽  
Carlos J. Rodriguez ◽  
Richard A. Kronmal ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Ethnic Study ◽  
Relationship Of ◽  
The Relationship

scholarly journals ASSOCIATION OF RIGHT ATRIAL FUNCTION WITH INCIDENT ATRIAL FIBRILLATION: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)

2017 ◽  
Vol 69 (11) ◽  
pp. 1570 ◽  
Author(s):  
Eric Xie ◽  
Ricky Yu ◽  
Bharath Ambale Venkatesh ◽  
Hooman Bakhshi ◽  
Susan Heckbert ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Atrial Function ◽  
Right Atrial ◽  
Ethnic Study ◽  
Right Atrial Function

scholarly journals Peripheral Arterial Disease and Risk of Atrial Fibrillation and Stroke: The Multi‐Ethnic Study of Atherosclerosis

2014 ◽  
Vol 3 (6) ◽  
Author(s):  
Wesley T. O'Neal ◽  
Jimmy T. Efird ◽  
Saman Nazarian ◽  
Alvaro Alonso ◽  
Susan R. Heckbert ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Ethnic Study ◽  
Peripheral Arterial

scholarly journals Fragmented Sinoatrial Dynamics in the Prediction of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis

2020 ◽  
Author(s):  
Madalena D. Costa ◽  
Susan Redline ◽  
Elsayed Z Soliman ◽  
Ary L Goldberger ◽  
Susan R Heckbert
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
High Risk ◽  
Added Value ◽  
Atrial Remodeling ◽  
Aging Research ◽  
Cox Models ◽  
Ethnic Study ◽  
Genomic Epidemiology

Heart rate fragmentation (HRF), a marker of abnormal sinoatrial dynamics, was shown to be associated with incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Here, we test the hypothesis that HRF is also associated with incident atrial fibrillation (AF) in the MESA cohort of participants who underwent in-home polysomnography (PSG) and in two high-risk subgroups: those ≥70 years taking antihypertensive medication and those with serum concentrations of N-terminal prohormone B-type natriuretic peptide (NT-proBNP) >125 pg/ml (top quartile). Heart rate time series (n=1,865) derived from the ECG channel of the PSG were analyzed using newly developed HRF metrics, traditional heart rate variability (HRV) indices and two widely used nonlinear measures. Eighty-three participants developed AF over a median follow-up period of 3.83 ± 0.87 years. A one-SD increase in HRF was associated with a 35% (95% CI: 7%-70%) increase in risk of incident AF, in Cox models adjusted for age, height, NT-proBNP and frequent premature supraventricular complexes. Furthermore, HRF added value to the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)-AF model. Traditional HRV and nonlinear indices were not significantly associated with incident AF. In the two high-risk subgroups defined above, HRF was also significantly associated with incident AF in unadjusted and adjusted models. These findings support the translational utility of HRF metrics for short-term (approximately four-year) prediction of AF. In addition, they support broadening the concept of atrial remodeling to include electrodynamical remodeling, a term used to refer to pathophysiologic alterations in sinus interbeat interval dynamics.

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