Diffuse Erythema and Acral Hyperkeratosis in a Newborn

Acute generalized exanthematous pustulosis is a rare condition characterized by sterile pustules on erythematous and edematous tissue. Mostly drug induced, this condition can also be caused by other factors. Cases due to vancomycin are rare. A 67-year-old woman with cellulitis of the left lower extremity was admitted with marked bilateral lymphedema of the lower extremities and diffuse erythema of the left lower extremity from foot to knee. She was given clindamycin and then vancomycin. On day 5, her condition worsened, with erythema involving the entire back. Although treatment with clindamycin and vancomycin was discontinued, acute generalized exanthematous pustulosis developed. After successful treatment of other complications, the skin condition improved. Because vancomycin is frequently used, clinicians should be aware of the possibility of acute generalized exanthematous pustulosis. Because the pustulosis decreases after withdrawal of the causative drug, being able to diagnose and differentiate the abnormality from other conditions is prudent.

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Diffuse erythema with ‘angel wings’ sign in Japanese patients with anti-small ubiquitin-like modifier activating enzyme antibody-associated dermatomyositis

British Journal of Dermatology ◽

10.1111/bjd.17026 ◽

2018 ◽

Vol 179 (6) ◽

pp. 1414-1415 ◽

Cited By ~ 3

Author(s):

S. Inoue ◽

N. Okiyama ◽

M. Shobo ◽

S. Motegi ◽

H. Hirano ◽

...

Keyword(s):

Japanese Patients ◽

Diffuse Erythema

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TANTANGAN FARMAKOLOGI PENGGUNAAN STEROID TOPIKAL PADA PASIEN ORAL LICHEN PLANUS

ODONTO Dental Journal ◽

10.30659/odj.6.1.30-36 ◽

2019 ◽

Vol 6 (1) ◽

pp. 30

Author(s):

Revi Nelonda ◽

Nanan Nur’aeny ◽

Irna Sufiawati

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Clinical Signs ◽

Topical Steroid ◽

Topical Steroids ◽

First Line ◽

Spicy Food ◽

Diffuse Erythema ◽

Chronic Autoimmune Disease ◽

Oral Lichen

Background: Oral lichen planus (OLP) is a chronic autoimmune disease sprinkled by T cells on the oral mucosal surface. The goal of OLP treatment is to eliminate erythema, ulceration and relieve symptoms. Corticosteroids are the first line in the treatment of OLP, either systemically or topically. The problem arises when using topical steroids, namely the time of topical steroid attachment to the oral mucosa, especially in cases of OLP with clinical desquamative gingivitis. Some studies suggest that the use of individual gingival tray can overcome this problem. Objective: To provide information on topical steroid use in OLP cases with desquamative gingivitis clinical signs.Case Management: Women, age 31, complain that pain with burning on the lips and mouth is aggravated by spicy food. Intraoral examination shows irregular white plaques on the buccal, labial and dorsal mucosa of the tongue accompanied by diffuse erythema in the anterior gingiva of the upper and lower jaws. Patients diagnosed with OLP. Lesions improve 3 months after topical steroid administration, except lesions on the gingiva. Gingival individual tray is then used to obtain adequate attachment of topical steroids on the gingiva surface. The gingiva showed significant improvement after a month later.Conclusion: The use of topical steroid concoctions applied to the gingival individual tray is effective in treating OLP lesions especially with clinical signs of desquamative gingivitis.

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Penis wound by scorpion sting

Sao Paulo Medical Journal ◽

10.1590/s1516-31801999000200007 ◽

1999 ◽

Vol 117 (2) ◽

pp. 85-86 ◽

Cited By ~ 2

Author(s):

Adriano Scaff Garcia ◽

Danielo Garcia de Freitas ◽

Osvaldo de Freitas Filho

Keyword(s):

Case Report ◽

Rare Case ◽

Medical Assistance ◽

Scorpion Sting ◽

Systemic Manifestation ◽

Relieve Pain ◽

Rare Case Report ◽

Diffuse Erythema ◽

Scorpion Stings ◽

Hands And Feet

CONTEXT: The majority of scorpion stings are oligosymptomatic, occurring mainly on the hands and feet. Fatality is rare. CASE REPORT: A 33-year old man suffered a severe sting on his penis from a scorpion of the species Tytius trivittatus. Alcohol and salt were used without success in an effort to relieve pain. Medical assistance was sought 4 hours after the event, at which time diffuse erythema, edema and punctiform injury on the glans penis were observed, with no systemic manifestation. Intravenous meperidine was administered with immediate relief of the pain. The local signs disappeared within 48 hours, with the patient remaining asymptomatic.

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Diffuse Erythema and Dry Scales in a Female Infant: Answer

American Journal of Dermatopathology ◽

10.1097/dad.0b013e3181f4ddc3 ◽

2011 ◽

Vol 33 (3) ◽

pp. 331-331

Author(s):

Liaqat Ali ◽

Carlos Ricotti ◽

Lily Li ◽

Antoanella Calame ◽

Brook Brouha ◽

...

Keyword(s):

Female Infant ◽

Diffuse Erythema

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Rapid Involution of Pustules during Topical Steroid Treatment of Acute Generalized Exanthematous Pustulosis

Case Reports in Dermatology ◽

10.1159/000471842 ◽

2017 ◽

Vol 9 (1) ◽

pp. 135-139 ◽

Cited By ~ 3

Author(s):

Christiane Kley ◽

Carla Murer ◽

Julia-Tatjana Maul ◽

Barbara Meier ◽

Florian Anzengruber ◽

...

Keyword(s):

Topical Steroid ◽

Steroid Treatment ◽

Clobetasol Propionate ◽

Topical Steroids ◽

First Line ◽

Acute Generalized Exanthematous Pustulosis ◽

Cutaneous Adverse Reaction ◽

Amoxicillin Clavulanic Acid ◽

Diffuse Erythema ◽

Exanthematous Pustulosis

Acute generalized exanthematous pustulosis (AGEP) is a dramatic generalized pustular rash of severe onset, which is considered a serious cutaneous adverse reaction to drugs. However, even though the clinical features are impressive and are often accompanied by systemic inflammation, it can be controlled quickly and safely by topical steroids subsequent to interruption of the offending drug. Here, we describe the management of a case and the evolution of the pustular rash. An elderly woman consulted with a generalized crop of 2–3 mm, nonfollicular pustules on erythematous background. In the 4 preceding weeks, she had been using amoxicillin/clavulanic acid for a bacterial implant infection and rivaroxaban. The clinical EuroSCAR criteria including the histology confirmed AGEP. Her medication was stopped and topical clobetasol propionate was used. Within 24 h, the development of new pustules ceased and the patient was discharged after 7 days of hospitalization with only a faint, diffuse erythema and focal desquamation remaining. This and many other cases in the literature suggest that topical steroids should be considered as a first-line treatment option, especially as systemic steroids themselves can sometimes induce generalized pustulosis.

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Sudden onset diffuse erythema and oedema of the breast

BMJ ◽

10.1136/bmj.h4166 ◽

2015 ◽

pp. h4166

Author(s):

Inês Vasconcelos ◽

Miguel de Sousa Mendes ◽

Jörg Linke ◽

Winfried Schoenegg

Keyword(s):

Sudden Onset ◽

Diffuse Erythema

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Epigenetics in Inflammatory Breast Cancer: Biological Features and Therapeutic Perspectives

Cells ◽

10.3390/cells9051164 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1164

Author(s):

Flavia Lima Costa Faldoni ◽

Cláudia Aparecida Rainho ◽

Silvia Regina Rogatto

Keyword(s):

Breast Cancer ◽

Inflammatory Breast Cancer ◽

Histone Deacetylase Inhibitors ◽

Clinical Presentation ◽

Lymphatic Invasion ◽

Common Denominator ◽

Epigenetic Alterations ◽

Diffuse Erythema ◽

Peau D’Orange ◽

Mammary Gland Differentiation

Evidence has emerged implicating epigenetic alterations in inflammatory breast cancer (IBC) origin and progression. IBC is a rare and rapidly progressing disease, considered the most aggressive type of breast cancer (BC). At clinical presentation, IBC is characterized by diffuse erythema, skin ridging, dermal lymphatic invasion, and peau d’orange aspect. The widespread distribution of the tumor as emboli throughout the breast and intra- and intertumor heterogeneity is associated with its poor prognosis. In this review, we highlighted studies documenting the essential roles of epigenetic mechanisms in remodeling chromatin and modulating gene expression during mammary gland differentiation and the development of IBC. Compiling evidence has emerged implicating epigenetic changes as a common denominator linking the main risk factors (socioeconomic status, environmental exposure to endocrine disruptors, racial disparities, and obesity) with IBC development. DNA methylation changes and their impact on the diagnosis, prognosis, and treatment of IBC are also described. Recent studies are focusing on the use of histone deacetylase inhibitors as promising epigenetic drugs for treating IBC. All efforts must be undertaken to unravel the epigenetic marks that drive this disease and how this knowledge could impact strategies to reduce the risk of IBC development and progression.

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Suspected Anaphylactic Reaction to Ketamine in 3 Yucatan Swine (Sus scrofa)

Comparative Medicine ◽

10.30802/aalas-cm-18-000148 ◽

2019 ◽

Vol 69 (5) ◽

pp. 419-424

Author(s):

Chelsea K Wallace ◽

Sara E Bell ◽

Philip C LaTourette ◽

Emily M Miedel ◽

Anthony J Carty ◽

...

Keyword(s):

Anaphylactic Reaction ◽

Emergency Preparedness ◽

Sus Scrofa ◽

Skin Testing ◽

Clinical Signs ◽

Case Series ◽

Miniature Swine ◽

Medical Interventions ◽

Diffuse Erythema ◽

Experimental Subjects

This case series describes the clinical courses of 3 juvenile Yucatan miniature swine (Sus scrofa) that experienced a suspected anaphylactic reaction to ketamine hydrochloride during premedication for protocol-related surgery. All 3 swine rapidly developed diffuse erythema shortly after injection with ketamine-containing drug combinations. Clinical signs ranged from tachycardia and erythema alone to tachycardia and erythema followed by respiratory and cardiac arrest. Ketamine was considered the most likely cause of these reactions because it was the only agent in the premedication sedation combination that was used in all 3 swine. Subsequent intradermal skin testing confirmed this suspicion. With supportive care measures and standard medical interventions for anaphylaxis, all 3 animals recovered well and went on to be successful experimental subjects when an alternative anesthetic regimen that did not contain ketamine was used. To our knowledge, this report is the first description of a suspected adverse ketamine reaction of this type in swine despite the widespread use of the drug in this species. Ketamine anaphylaxis is rare in people, but the few cases described presented with symptoms similar to the clinical signs seen in the pigs in this report. In addition to highlighting a potential adverse drug reaction to ketamine in swine, this case series demonstrates the value of emergency preparedness for even the most routine of procedures.

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Erosive acute colitis associated with intestinal spirochetosis

Surgical and Experimental Pathology ◽

10.1186/s42047-021-00100-8 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Fabio Dantas de Paula ◽

Glicia Estevam de Abreu ◽

Maiara Ferreira de Souza ◽

Luiz Antonio Rodrigues de Freitas ◽

Daniel Abensur Athanazio

Keyword(s):

Rectal Biopsy ◽

Risk Groups ◽

Chronic Inflammatory Bowel Disease ◽

Architectural Distortion ◽

Sexually Transmitted ◽

Intestinal Spirochetosis ◽

Disease Case ◽

Bowel Diseases ◽

Diffuse Erythema ◽

Active Inflammation

Abstract Background Although usually believed to be harmless, intestinal spirochetosis may active erosive colitis associated with intestinal spirochetosis that may mimic idiopathic chronic inflammatory bowel disease. Case presentation. A 49-year-old homosexual male patient sought medical assistance due to asthenia, rectal bleeding, tenesmus, and diarrhea for one month. He had been using corticosteroids for nine months to treat sciatic nerve pain. Colonoscopy showed rectum and distal sigmoid with diffuse erythema with many surface erosions. Rectal biopsy showed inflammatory changes including chronic changes such as architectural distortion and basal plasmacytosis, and active inflammation including crypt microabscesses. In all large bowel sample, dense colonization of intestinal spirochetosis was observed. Patient also had a positive PCR testing for Chlamydia trachomatis. The patient was treated with metronidazole for 14 days, ciprofloxacin for 14 days and azithromycin (single dose). Symptoms improved and the patient is asymptomatic after two months of follow-up. Conclusion In some high-risk groups, intestinal spirochetosis may cause colonic manifestations with overlapping features with intestinal bowel diseases. Awareness of this association is importance since proper antibiotic therapy against Brachyspira (metronidazole) is highly effective. Coinfection with other sexually transmitted infections is common and proper treatment is required.

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