Use of β-blockers and effects on heart rate and blood pressure post-acute coronary syndromes: Are we on target?

2009 ◽  
Vol 158 (3) ◽  
pp. 378-385 ◽  
Author(s):  
Michael Herman ◽  
Jennifer Donovan ◽  
Maichi Tran ◽  
Brigid McKenna ◽  
Joel M. Gore ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes ◽  
Β Blockers

The effect of diabetes on heart rate and other determinants of myocardial oxygen demand in acute coronary syndromes

2004 ◽  
Vol 21 (9) ◽  
pp. 1025-1031 ◽  
Author(s):  
K. Foo ◽  
N. Sekhri ◽  
C. Knight ◽  
A. Deaner ◽  
J. Cooper ◽  
...  
Keyword(s):  
Heart Rate ◽  
Acute Coronary Syndromes ◽  
Oxygen Demand ◽  
Myocardial Oxygen Demand ◽  
Coronary Syndromes

scholarly journals What Is the Optimal Blood Pressure in Patients After Acute Coronary Syndromes?

Circulation ◽  
2010 ◽  
Vol 122 (21) ◽  
pp. 2142-2151 ◽  
Author(s):  
Sripal Bangalore ◽  
Jie Qin ◽  
Sarah Sloan ◽  
Sabina A. Murphy ◽  
Christopher P. Cannon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes ◽  
Optimal Blood Pressure

scholarly journals Prior Beta-Blocker Therapy for Hypertension and Sex-Based Differences in Heart Failure Among Patients With Incident Coronary Heart Disease

Hypertension ◽  
2020 ◽  
Vol 76 (3) ◽  
pp. 819-826 ◽  
Author(s):  
Raffaele Bugiardini ◽  
Jinsung Yoon ◽  
Sasko Kedev ◽  
Goran Stankovic ◽  
Zorana Vasiljevic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Odds Ratio ◽  
Acute Coronary Syndromes ◽  
Relative Risk Ratio ◽  
Blocker Therapy ◽  
Coronary Syndromes ◽  
Β Blocker ◽  
Β Blockers

The usefulness of β-blockers has been questioned for patients who have hypertension without a prior manifestation of coronary heart disease or heart failure. In addition, sex-based differences in the efficacy of β-blockers for prevention of heart failure during acute myocardial ischemia have never been evaluated. We explored whether the effect of β-blocker therapy varied according to the sex among patients with hypertension who have no prior history of cardiovascular disease. Data were drawn from the ISACS (International Survey of Acute Coronary Syndromes)-Archives. The study population consisted of 13 764 patients presenting with acute coronary syndromes. There were 2590 patients in whom hypertension was treated previously with β-blocker (954 women and 1636 men). Primary outcome measure was the incidence of heart failure according to Killip class classification. Subsidiary analyses were conducted to estimate the association between heart failure and all-cause mortality at 30 days. Outcome rates were assessed using the inverse probability of treatment weighting and logistic regression models. Estimates were compared by test of interaction on the log scale. Among patients taking β-blockers before admission, there was an absolute difference of 4.6% between women and men in the rate of heart failure (Killip ≥2) at hospital presentation (21.3% versus 16.7%; relative risk ratio, 1.35 [95% CI, 1.10–1.65]). On the opposite, the rate of heart failure was approximately similar among women and men who did not receive β-blockers (17.2% versus 16.1%; relative risk ratio, 1.09 [95% CI, 0.97–1.21]). The test of interaction identified a significant ( P =0.034) association between sex and β-blocker therapy. Heart failure was predictive of mortality at 30-day either in women (odds ratio, 7.54 [95% CI, 5.78–9.83]) or men (odds ratio, 9.62 [95% CI, 7.67–12.07]). In conclusion, β-blockers use may be an acute precipitant of heart failure in new-onset coronary heart disease among women, but not men. Heart failure increases the risk of death. Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT04008173.

scholarly journals Gambaran Tekanan Darah pada Pasien Sindrom Koroner Akut di RS Khusus Jantung Sumatera Barat Tahun 2011-2012

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Meidiza Ariandiny ◽  
Afriwardi Afriwardi ◽  
Masrul Syafri
Keyword(s):  
Blood Pressure ◽  
Acute Coronary Syndrome ◽  
High Blood Pressure ◽  
Acute Coronary Syndromes ◽  
Univariate Analysis ◽  
Gender Classification ◽  
Coronary Syndrome ◽  
Coronary Syndromes ◽  
Heart Hospital

AbstrakPenyakit jantung koroner merupakan penyakit degeneratif dengan permasalahan yang serius karena prevalensinya yang terus meningkat. Keadaan yang mengkhawatirkan dari penyakit jantung koroner adalah pada fase akut atau disebut dengan sindrom koroner akut. Salah satu faktor yang menyebabkan terjadinya sindrom koroner akut adalah tekanan darah yang tinggi yang mengakibatkan pecahnya plak aterosklerotik. Penelitian bertujuan untuk mengetahui gambaran tekanan darah pada pasien sindrom koroner akut di RS Khusus Jantung, Sumatera Barat dan mengetahui jenis hipertensi yang terjadi. Penelitian dilakukan dengan mengambil data sekunder yaitu data tekanan darah awal masuk rumah sakit pada pasien sindrom koroner akut di RS Khusus Jantung, Sumatera Barat pada bulan Maret-April 2013. Penelitian ini merupakan studi deskriptif observasional dengan total sampling. Analisis data yang dilakukan adalah analisis univariat. Hasil penelitian dari 145 data ditemukan bahwa hipertensi (tekanan darah tinggi) sebanyak 88 pasien (61%), prehipertensi sebanyak 33 pasien (23%), dan normotensi sebanyak 24 pasien (16%), dengan jenis hipertensi yaitu hipertensi kombinasi sebanyak 53 pasien (60%), hipertensi sistolik sebanyak 20 pasien (23%) dan hipertensi diastolik sebanyak 15 pasien (17%). Kelompok usia yang terbanyak yaitu usia 46-55 tahun (30%) diikuti kelompok usia 66-75 tahun (25%), 56-65 tahun (24%), >76 tahun (10%), 36-45 tahun (0,8%), dan < 35 tahun (0,2%) dengan jenis kelamin laki-laki sebesar 74% dan perempuan sebesar 26%. Kesimpulan dari hasil penelitian adalah gambaran tekanan darah pada pasien sindrom koroner akut yang terbanyak yaitu hipertensi dengan jenis hipertensi kombinasi. Kelompok usia terbanyak yaitu usia 46-55 tahun dengan jenis kelamin laki-laki.Kata kunci: tekanan darah, hipertensi, sindrom koroner akutAbstractCoronary heart disease is a degenerative disease. It becomes serious because the prevalence continues increase. The worst condition is the acute phase which is called acute coronary syndrome. The high blood pressure is one of the risk factors of acute coronary syndrome because it lead atherosclerotic plaques ruptured. This research aims is to describe the blood pressure and the type of hypertension in patients with acute coronary syndromes in The Heart Hospital, West Sumatera. This research took the secondary data of admission blood pressure in patients hospitalized with acute coronary syndrome in The Heart Hospital, West Sumatera, March - April 2013. This research is an observational descriptive study with a total sampling. Data analysis was performed univariate analysis. The results of 145 data were 88 patients (61%) had hypertension (high blood pressure), 33 patients (23%) were prehypertension, and 24 were normotensive (16%). The type of hypertension were 53 patients with combination hypertension (60%), 20 patients with systolic hypertension (23%) and 15 patients with diastolic hypertension (17%). Based on the age classification of hypertension, found that 46-55 years were 30%, 66-75 years were 25%, 56-65 years were 24%, > 76 years were 10%, 36-45 years were 0.8%, and < 35 years were 0.2%. based on gender classification of hypertension found that male gender were 74% and women were 26%. The conclusion of this research find that the largest blood pressure in patients with acute coronary syndromes is hypertension, the largest type of hypertension is combination hypertension, the largest age classification is 46-55 years, and the largest gender classification is male.Keywords:blood pressure, hypertension, acute coronary syndrome

scholarly journals Influence of new ultra-short-acting β-blockers on selected physiological indicators in laboratory rats

2017 ◽  
Vol 62 (No. 9) ◽  
pp. 493-507
Author(s):  
O. Bado ◽  
M. Dlouha ◽  
E. Kolmanova ◽  
M. Frydrych
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Hypotensive Effect ◽  
Basic Unit ◽  
The European Union ◽  
Qrs Complex ◽  
Perfusion System ◽  
Short Acting ◽  
Physiological Indicators ◽  
Β Blockers

High rates of cardiovascular mortality have long been a serious problem in all European countries. Despite advancements in health care the situation is not improving fast enough. In the last decades, no new ultra-short-acting β-blockers have been registered in the European Union except for esmolol and landionol. In this study, eight newly-synthesised ultra-short-acting β-blockers were tested. These β-blockers contain an ester functional group which can be easily cleaved by plasma or cytoplasmic esterases. The substances were prepared in the Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno. Systolic blood pressure, heart rate and the interval of the QRS complex were evaluated using normotensive laboratory Wistar rats. The tested compounds were administered intravenously into the vena jugularis during general anaesthesia. The arteria carotis was exposed and cannulated to a Universal Perfusion System Basic Unit (UPSBU) of type Uniper UP-100. The universal perfusion system for isolated organs was capable of measuring and transducing actual values of blood pressure. ECG records were made using the ECG SEIVA – Praktik Veterinary. A series of substances named 2FC2a, 2FC2b, 2FC2c, 2FC2d, and another series with substances named 2FT2a, 2FT2b, 2FT2c, 2FT2d were tested at a dose of 3 mg/kg. Results were statistically compared to placebo. The best results were obtained for propyl and butyl derivatives with the highest lipophilicity. These acted as the best blood pressure reducers immediately after their administration. None of the compounds notably affected the heart rate. Statistical data show that carbamate substitution considerably prolongated the duration of the QRS complex as compared to placebo or etheric substitution. The carbamate substitution caused a pronounced arrhythmogenic effect. Thus, we could confirm the short-term hypotensive effect of the compounds. We observed an effect on the electrical conduction system of the heart while no effects were observed on heart rate. Our study contributes to better describing potential new ultra-short-acting β-blockers and facilitates selection for further testing.

Rationale and Design of the ACS-BP Study: Prognostic Value of In-Hospital Blood Pressure and Indices of Atherosclerosis in Acute Coronary Syndromes

2020 ◽  
Vol 18 ◽  
Author(s):  
Areti Koumelli ◽  
Konstantinos Konstantinou ◽  
Alexandros Kasiakogias ◽  
Kyriakos Dimitriadis ◽  
Ioannis Leontsinis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Risk Stratification ◽  
Acute Coronary Syndromes ◽  
Ankle Brachial Index ◽  
Stiffness Index ◽  
St Segment Elevation ◽  
Study Results ◽  
Coronary Syndromes

Background: High blood pressure (BP) is a leading risk factor for coronary artery disease and other major cardiovascular events. Objective: Blood pressure variability (BPV), ambulatory arterial stiffness index (AASI) and ankle-brachial index (ABI) have been proposed as indices that can improve risk stratification for an adverse cardiac outcome. However, their utility in the setting of acute coronary syndromes (ACS) is unclear. Methods: The ACS-BP study is a single-centre observational cohort study designed to investigate the prognostic role of haemodynamic load and arterial stiffness indices for cardio-renal outcomes in patients with acute myocardial infarction (AMI). All consecutive patients admitted with a diagnosis of acute AMI with or without ST segment elevation will be screened for inclusion in the study. The management of AMI will follow current guidelines. Results and Discussion: Data from baseline clinical and laboratory parameters during their hospitalization will be collected. The haemodynamic load of each patient will be determined by clinical BP values as well as 24-h ambulatory BP monitoring. The AASI will be calculated from the raw 24-h BP data and ABI will be measured after the third day of hospitalization using a certified device. Patients will be followed-up for 12 months in order to collect data for hard cardiovascular and renal endpoints. Conclusion: The study results should clarify the role of these non-invasive tools in secondary risk stratification of such patients.

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