Patient preferred live music with adult medical patients: A systematic review to determine implications for clinical practice and future research

Platelet products (PP) and bone-marrow aspirate are popular sources of osteoinductive signalling molecules and osteogenic bone marrow mesenchymal stromal cells (BM-MSCs) used in the treatment of impaired bone healing. However, the combined use of PP and BM-MSCs in clinical studies has reported mixed results. Understanding the cellular and molecular interactions between PP and BM-MSCs plays the important role of guiding future research and clinical application. This systematic review investigates the effects of PP on the biophysiological functions of BM-MSCs in in vitro human studies, including (i) proliferation, (ii) migration, (iii) differentiation, (iv) growth factor/cytokine/protein expression, (v) immunomodulation, (vi) chemotactic effect on haematopoietic stem cells, (vii) response to apoptotic stress, and (viii) gene expression. In vitro studies in human have demonstrated the multi-faceted ‘priming effect’ of PP on the biophysiological functions of BM-MSCs. PP has been shown to improve proliferation, migration, osteogenic differentiation, reaction to apoptotic stress as well as immunomodulatory, pro-angiogenic and pro-inflammatory capacities of BM-MSCs. Several factors are highlighted that restrict the transferability of these findings into clinical practice. Therefore, more collaborative in vitro research in humans modelled to reflect clinical practice is required to better understand the effects of PP exposure on the biophysiological function(s) of BM-MSCs in human.

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A Systematic Review of Unpublished and Non-Refereed Music Therapy Mental Health Papers Found via Google Scholar

Voices A World Forum for Music Therapy ◽

10.15845/voices.v18i2.960 ◽

2018 ◽

Vol 18 (2) ◽

Author(s):

Melody R Peterson ◽

Michael J Silverman

Keyword(s):

Mental Health ◽

United States ◽

Systematic Review ◽

Clinical Practice ◽

Music Therapy ◽

The United States ◽

Google Scholar ◽

Future Research ◽

Mental Health Literature ◽

Doctoral Dissertations

As Google Scholar searches yield unpublished papers, it may inadvertently impact the perception of the music therapy literature for clinicians, researchers, and service users. Therefore, the purpose of this systematic review was to identify and analyze the current literature comprised of unpublished and non-refereed papers regarding music therapy and mental health from January 2000 to September 2017 located via Google Scholar. After establishing inclusion and exclusion criteria, papers were identified using a variety of combinations of music therapy and mental health keywords. Twenty-one papers met inclusion criteria. Sixteen papers were master’s theses and five were doctoral dissertations. Almost half of the papers (n = 8) involved adolescents with mental health diagnoses. Although not all papers contained data, more papers contained qualitative data (n = 10) than quantitative data (n = 3). The unpublished music therapy and mental health literature may represent a valuable resource for guiding clinical practice and research. As the majority of authors were affiliated with universities outside the United States, perhaps there is greater interest in mental health outside the United States. It is concerning that many identified papers required additional login credentials. Implications for clinical practice, limitations, and suggestions for future research are provided.

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A systematic review of cognitive remediation therapy for anorexia nervosa - development, current state and implications for future research and clinical practice

Journal of Eating Disorders ◽

10.1186/s40337-014-0026-y ◽

2014 ◽

Vol 2 (1) ◽

Cited By ~ 31

Author(s):

Camilla Lindvall Dahlgren ◽

Øyvind Rø

Keyword(s):

Systematic Review ◽

Anorexia Nervosa ◽

Clinical Practice ◽

Cognitive Remediation ◽

Future Research ◽

Cognitive Remediation Therapy ◽

Current State

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Thermography in Neurologic Practice

The Open Neurology Journal ◽

10.2174/1874205x01509010024 ◽

2015 ◽

Vol 9 (1) ◽

pp. 24-27 ◽

Cited By ~ 15

Author(s):

Eduardo Borba Neves ◽

José Vilaça-Alves ◽

Claudio Rosa ◽

Victor Machado Reis

Keyword(s):

Systematic Review ◽

Clinical Practice ◽

Experimental Design ◽

Complex Regional Pain Syndrome ◽

Diagnostic Tool ◽

Pain Syndrome ◽

Future Research ◽

Monitoring Tool ◽

Chronological Period ◽

Infrared Cameras

One kind of medical images that has been developed in the last decades is thermal images. These images are assessed by infrared cameras and have shown an exponential development in recent years. In this sense, the aim of this study was to describe possibilities of thermography usage in the neurologic practice. It was performed a systematic review in Web of Knowledge (Thompson Reuters), set in all databases which used two combination of keywords as “topic”: “thermography” and “neurology”; and “thermography” and “neurologic”. The chronological period was defined from 2000 to 2014 (the least 15 years). Among the studies included in this review, only seven were with experimental design. It is few to bring thermography as a daily tool in clinical practice. However, these studies have suggested good results. The studies of review and an analyzed patent showed that the authors consider the thermography as a diagnostic tool and they recommend its usage. It can be concluded that thermography is already used as a diagnostic and monitoring tool of patients with neuropathies, particularly in complex regional pain syndrome, and stroke. And yet, this tool has great potential for future research about its application in diagnosis of other diseases of neurological origin.

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Barriers and Facilitators to the Uptake of New Medicines into Clinical Practice: A Systematic Review

10.21203/rs.3.rs-571753/v1 ◽

2021 ◽

Author(s):

Kristina Medlinskiene ◽

Justine Tomlinson ◽

Iuri Marques ◽

Sue Richardson ◽

Katherine Stirling ◽

...

Keyword(s):

Systematic Review ◽

Clinical Practice ◽

Secondary Data ◽

Cost Effective ◽

Organizational Factors ◽

Barriers And Facilitators ◽

Future Research ◽

Framework Analysis ◽

Factors Affecting ◽

Wide Range

Abstract Background: Implementation and uptake of novel and cost-effective medicines can improve patient health outcomes and healthcare efficiency. However, the uptake of new medicines into practice faces a wide range of obstacles Earlier reviews provided insight into determinants for new medicine uptake (such as medicine, prescriber, patient, organization, and external environment factors), but the methodological approaches used had limitations (e.g., single author, narrative review, narrow search, no quality assessment of reviewed evidence).This systematic review aims to identify barriers and facilitators affecting the uptake of new medicines into clinical practice and identify areas for future research. Method: A systematic search was undertaken within seven databases. Eligible qualitative, quantitative, and mixed-methods studies focused on adult participants (18 years and older) requiring or taking new medicine(s) for any condition, in the context of healthcare organizations and identified factors affecting the uptake of new medicines. The methodological quality was assessed using QASTDD tool. A narrative synthesis of reported factors was conducted using framework analysis and conceptual framework was utilised to group them. Results: A total of 66 studies were included. Most studies (n=62) were quantitative and used secondary data (n=46) from various databases, e.g., insurance databases. The identified factors had a varied impact on the uptake of the different studied new medicines. Differently from earlier reviews, patient factors (patient education, engagement with treatment, therapy preferences), cost of new medicine, reimbursement and formulary conditions, and guidelines were suggested to influence the uptake. Also, the review highlighted that health economics, wider organizational factors, and underlying behaviours of adopters were not or under explored. Conclusion: This systematic review identifies additional factors affecting new medicine use not reported in earlier reviews, which included patient influence and education level, cost of new medicines, formulary and reimbursement restrictions, and guidelines. Further research employing determinant frameworks or implementation theories is needed to gain a better understanding of factors, especially patient, prescriber, and organizational, affecting the uptake of new medicines into clinical practice.Registration: PROSPERO database (CRD42018108536)

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OP74 Stoma Cover Use By Fully Laryngectomized Patients

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462319001314 ◽

2019 ◽

Vol 35 (S1) ◽

pp. 18-18

Author(s):

Simon Deblois ◽

Sylvain L'Espérance ◽

Martin Coulombe ◽

Luigi Lepanto ◽

Marc Rhainds

Keyword(s):

Systematic Review ◽

Clinical Practice ◽

Methodological Quality ◽

Conflicts Of Interest ◽

Clinical Effectiveness ◽

Conclusive Evidence ◽

Future Research ◽

Common Clinical Practice ◽

Study Designs ◽

Heat And Moisture

IntroductionThe use of stoma covers has been a common clinical practice for laryngectomized patients for several years. In the province of Québec, Canada, laryngectomized patients can obtain stoma covers through a dedicated program providing them with medical supplies and voice re-education services. For many years, the program's supply has included cloth and/or foam covers, but the supply of Heat and Moisture Exchangers (HME) has been limited. Two hospital-based HTA units joined their expertise to assess the opportunity of providing HMEs to more patients, depending on their clinical characteristics.MethodsTheir joined assessment rested on a systematic review (SR) and a field assessment. The systematic review aimed at assessing the efficacy, clinical effectiveness and safety of various types of stoma covers. The field inquiries intended to assess the perceptions of clinicians and managers towards stoma covers in clinical practice.ResultsWe included 27 studies in the SR. Most of them appraised the clinical effectiveness or safety of HME filters. Their methodological quality was very low with potential conflicts of interest whereas many studies were financed by the industry. The heterogeneity of study designs, expected outcomes and paucity of comparative studies prevented the pooling of results. Industry sponsorship appeared to be an important issue, since 17 of the included studies were sponsored. The SR did not provide conclusive evidence concerning the efficacy, clinical effectiveness and safety of the various types of stoma covers. The field inquiries intended to assess the perceptions of clinicians and managers towards stoma covers in clinical practice. It showed that industry representatives are quite active in clinical settings, promoting their products. Clinicians’ opinions and preferences were coherent with the systematic review main observations: in a context where the quality of the evidence is low, clinicians’ recommendations of stoma protectors for laryngectomies are mainly based on their professional experience and academic training.ConclusionsFuture research of high methodological quality would strengthen the evidence concerning the relative efficacy and safety of different stoma protectors. These studies would help define evidence-based allocation criteria and set parameters so that the choice of a stoma protector is best adapted to a laryngectomized patients’ condition.

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Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis

Blood ◽

10.1182/blood.2019003603 ◽

2020 ◽

Vol 135 (20) ◽

pp. 1788-1810 ◽

Cited By ~ 15

Author(s):

Andrea J. Darzi ◽

Samer G. Karam ◽

Rana Charide ◽

Itziar Etxeandia-Ikobaltzeta ◽

Mary Cushman ◽

...

Keyword(s):

Systematic Review ◽

Prognostic Factors ◽

Critical Illness ◽

Meta Analysis ◽

Previous History ◽

Venous Catheter ◽

Older Age ◽

Future Research ◽

Medical Patients ◽

History Of

Abstract There may be many predictors of venous thromboembolism (VTE) and bleeding in hospitalized medical patients, but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify prognostic factors for VTE and bleeding in hospitalized medical patients and searched Medline and EMBASE from inception through May 2018. We considered studies that identified potential prognostic factors for VTE and bleeding in hospitalized adult medical patients. Reviewers extracted data in duplicate and independently and assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. Of 69 410 citations, we included 17 studies in our analysis: 14 that reported on VTE, and 3 that reported on bleeding. For VTE, moderate-certainty evidence showed a probable association with older age; elevated C-reactive protein (CRP), D-dimer, and fibrinogen levels; tachycardia; thrombocytosis; leukocytosis; fever; leg edema; lower Barthel Index (BI) score; immobility; paresis; previous history of VTE; thrombophilia; malignancy; critical illness; and infections. For bleeding, moderate-certainty evidence showed a probable association with older age, sex, anemia, obesity, low hemoglobin, gastroduodenal ulcers, rehospitalization, critical illness, thrombocytopenia, blood dyscrasias, hepatic disease, renal failure, antithrombotic medication, and presence of a central venous catheter. Elevated CRP, a lower BI, a history of malignancy, and elevated heart rate are not included in most VTE risk assessment models. This study informs risk prediction in the management of hospitalized medical patients for VTE and bleeding; it also informs guidelines for VTE prevention and future research.

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