Epidemiologic and Molecular Investigation of a Cluster of Cases of Carbapenemase-producing Klebsiella pneumoniae (KPC) in a Rural North Carolina Hospital

2011 ◽  
Vol 39 (5) ◽  
pp. E121-E122
Author(s):  
Elaine Ayers ◽  
K.L. Augustino ◽  
K.M. Ramsey
Keyword(s):  
North Carolina ◽  
Klebsiella Pneumoniae ◽  
Molecular Investigation ◽  
North Carolina Hospital

The Impact on Resource Utilization of Supportive Care Consults on Patients at the University of North Carolina Hospital, 2010–2012

2018 ◽  
Vol 21 (2) ◽  
pp. 216-219 ◽  
Author(s):  
Kristen Westfall ◽  
Dominic Moore ◽  
Matthew Meeneghan ◽  
Sandra Jarr ◽  
John Valgus ◽  
...  
Keyword(s):  
North Carolina ◽  
Supportive Care ◽  
Resource Utilization ◽  
University Of North Carolina ◽  
The University ◽  
The Impact ◽  
North Carolina Hospital

A 7-year surveillance for ESBL-producing Escherichia coli and Klebsiella pneumoniae at a university hospital in Taiwan: the increase of CTX-M-15 in the ICU

2009 ◽  
Vol 138 (2) ◽  
pp. 253-263 ◽  
Author(s):  
J. C. SHU ◽  
J. H. CHIA ◽  
A. J. KUO ◽  
L. H. SU ◽  
T. L. WU
Keyword(s):  
Escherichia Coli ◽  
Klebsiella Pneumoniae ◽  
Genetic Relatedness ◽  
Horizontal Transmission ◽  
Clonal Expansion ◽  
Tertiary Hospital ◽  
University Hospital ◽  
Molecular Investigation ◽  
Resistance Plasmids ◽  
Changing Trend

SUMMARYTo monitor the changing trend of extended-spectrum β-lactamase (ESBL)-producing bacteria, a 7-year continuous study was launched in 2001 at the largest tertiary hospital in Taiwan. A significant increase over the study period was evident for ESBL-producing isolates of Escherichia coli (4·8–10·0%) and Klebsiella pneumoniae (15·0–23·4%). Molecular investigation conducted in three separate periods revealed the prevalent ESBL types and their genetic relatedness. CTX-M-producing isolates (73·8%) were more prevalent than SHV-type ESBLs (37·0%), the most frequent being CTX-M-14 (34·3%), CTX-M-3 (25·9%), and SHV-12 (25·7%). However, a marked increase of CTX-M-15-producing isolates from 2·1% in 2002 to 29·6% in 2007 was also noted. The increase of ESBL-producing isolates in both species may be mainly due to the horizontal transmission of resistance plasmids, while clonal expansion of some epidemic strains further added to the dispersion of ESBL-producing K. pneumoniae.

scholarly journals Molecular Investigation of Klebsiella pneumoniae from Clinical Companion Animals in Beijing, China, 2017–2019

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 271
Author(s):  
Zhenbiao Zhang ◽  
Lei Lei ◽  
Haixia Zhang ◽  
Hegen Dai ◽  
Yu Song ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Typing ◽  
Galleria Mellonella ◽  
Companion Animals ◽  
Whole Genome ◽  
Molecular Investigation ◽  
Amoxicillin Clavulanate ◽  
Resistance Rates ◽  
Beijing China ◽  
Sequence Types

This work is aimed to elucidate the prevalence and characteristics of antimicrobial resistance, virulence, and molecular typing in Klebsiella pneumoniae from clinical companion animals in Beijing, China. In total, 105 K. pneumoniae (2.0%) isolates were recovered from 5359 samples (dogs, n = 3356; cats, n = 2003). All tested isolates exhibited high resistance to amoxicillin-clavulanate (74.3%). Moreover, resistance rates in dog isolates (2.1%) were significantly higher than in cat isolates (0.9%); however, the rate of multidrug-resistance (MDR) was 57.1% and the MDR prevalence in cats was significantly higher than dogs. Whole-genome sequencing demonstrated plasmids IncX4 and IncFIA (HI1)/FII(K) carried mcr-1 (n = 1) and mcr-8 (n = 1), but blaOXA-181 (n = 1) and blaNDM-5 (n = 4) were harbored in IncX3-type plasmids, and the above genes were in different isolates. The most prevalent sequence types (STs) in companion animals were ST1 (n = 9) and ST37 (n = 9). Compared to National Center for Biotechnology Information (NCBI) data on human K. pneumoniae, resistance genes blaCTX-M and blaTEM were more prevalent in human isolates; however, aac(6’)-Ib-cr and oqxAB showed a higher prevalence in companion animals. Hypermucoviscosity was reported in 9 (8.6%) isolates, whereas 64 isolates (61.0%) were hypervirulent K. pneumoniae (hvKP) via the Galleria mellonella. These findings validate the high risk of K. pneumonia and necessitate its relevant control in pet clinics.

Between ‘Savage Man’ and ‘Most Faithful Englishman’ Manteo and the Early Anglo-Indian Exchange, 1584–1590

Itinerario ◽  
2000 ◽  
Vol 24 (2) ◽  
pp. 146-169 ◽  
Author(s):  
Michael Leroy Oberg
Keyword(s):  
North Carolina ◽  
Chesapeake Bay ◽  
One Year ◽  
Anglo Indian

In August of 1587 Manteo, an Indian from Croatoan Island, joined a group of English settlers in an attack on the native village of Dasemunkepeuc, located on the coast of present-day North Carolina. These colonists, amongst whom Manteo lived, had landed on Roanoke Island less than a month before, dumped there by a pilot more interested in hunting Spanish prize ships than in carrying colonists to their intended place of settlement along the Chesapeake Bay. The colonists had hoped to re-establish peaceful relations with area natives, and for that reason they relied upon Manteo to act as an interpreter, broker, and intercultural diplomat. The legacy of Anglo-Indian bitterness remaining from Ralph Lane's military settlement, however, which had hastily abandoned the island one year before, was too great for Manteo to overcome. The settlers found themselves that summer in the midst of hostile Indians.

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