308: Stereological analysis of human myometrium in third trimester pregnancy: influence of maternal age, body mass index and parity

Hemogloin (Hb) and serum ferritin levels are used to assess anemia in pregnancy. Some studies referred to the influence of maternal age, body mass index (BMI) and parity on Hb and serum ferritin levels. The study aimed to examine the possible association of maternal Hb and serum ferritin with maternal age, parity, and BMI in a sample of pregnant women in Baghdad. Ninety healthy pregnant women, grouped in three equal groups according to the pregnancy trimester, and thirty apparently healthy non-pregnant women from Baghdad were enrolled in this observational study. Blood and serum samples were obtained for the estimation of Hb and serum ferritin levels. The pooled data of participants showed a negative correlation between parity and each of blood Hb concentrations (r= -0.147, P=0.046) and plasma ferritin levels (r= -0.186, P= 0.038). The negative correlation of parity with blood Hb concentration was reported in participants in the third trimester of pregnancy (r= -0.270, P=0.048); and between parity and plasma ferritin levels in the second (r= -0.088, P= 0.046) and third (r= -0.398, P=0.029) trimester pregnant. The study did not report a significant correlation between age and BMI with blood Hb concentrations or serum ferritin levels in pregnant women at any trimester of pregnancy. There is a negative correlation between parity and each of blood Hb concentration and serum ferritin levels in pregnant women in Baghdad. While, there is no such correlation with maternal age and BMI at any trimester of pregnancy.

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Age, body mass index, and weight gain do not increase sympathetic activity during pregnancy

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2019-0704 ◽

2020 ◽

Vol 45 (9) ◽

pp. 1041-1044

Author(s):

Laura M. Reyes ◽

Mark B. Badrov ◽

Qi Fu ◽

Craig D. Steinback ◽

Margie H. Davenport

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Pregnant Women ◽

Body Mass ◽

Sympathetic Activity ◽

Maternal Age ◽

Third Trimester ◽

Rapid Weight Gain ◽

Gestational Weight ◽

Normotensive Pregnancy

Associations between prepregnancy body mass index, gestational weight gain, maternal age, and basal sympathetic nervous system activity (SNA) in normotensive pregnant women have not been explored. Retrospective analysis of microneurography records from 74 normotensive pregnant women during their third trimester indicated that although pregnancy is associated with rapid weight gain, this does not influence SNA. There were also no associations between maternal age and SNA, but more studies are needed to confirm this interpretation. Novelty Neither age nor excessive weight gain appears to influence sympathetic activity during normotensive pregnancy.

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Faculty Opinions recommendation of An analysis of the interrelationship between maternal age, body mass index and racial origin in the development of gestational diabetes mellitus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13997958.15454059 ◽

2012 ◽

Author(s):

Steven Witkin

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Body Mass ◽

Maternal Age ◽

Racial Origin

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Assessing the relationship between pregravid body mass index and risk of adverse maternal pregnancy and neonatal outcomes: prospective data in Southwest China

Scientific Reports ◽

10.1038/s41598-021-87135-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yue Chen ◽

Ke Wan ◽

Yunhui Gong ◽

Xiao Zhang ◽

Yi Liang ◽

...

Keyword(s):

Body Mass Index ◽

Cesarean Delivery ◽

Body Mass ◽

Gestational Age ◽

Pregnancy Outcomes ◽

Maternal Age ◽

Southwest China ◽

Adverse Pregnancy Outcomes ◽

Relative Importance ◽

Adverse Pregnancy

AbstractThe relevance of pregestational body mass index (BMI) on adverse pregnancy outcomes remained unclear in Southwest China. This study aimed to investigate the overall and age-category specific association between pre-gestational BMI and gestational diabetes mellitus (GDM), preeclampsia, cesarean delivery, preterm delivery, stillbirth, macrosomia, and small-for-gestational age (SGA) or large-for-gestational age (LGA) neonates in Southwest China. Furthermore, it explores the relative importance of influence of pregravid BMI and maternal age on pregnancy outcomes. 51,125 Chinese singleton pregnant women were recruited as study subjects. Multiple logistic regression models were used to examine the influence of pre-pregnancy BMI on adverse pregnancy outcomes. Gradient boosting machine was used to evaluate the relative importance of influence of pregravid BMI and maternal age on pregnancy outcomes. It is found that women who were overweight or obese before pregnancy are at higher risk of adverse pregnancy outcomes except for SGA neonates, while pre-pregnancy underweight is a protective factor for GDM, preeclampsia, cesarean delivery, macrosomia and LGA, but not SGA. Younger mothers are more susceptible to GDM and macrosomia neonates, while older mothers are more prone to preeclampsia. Pre-pregnancy BMI has more influence on various pregnancy outcomes than maternal age. To improve pregnancy outcomes, normal BMI weight as well as relatively young maternal ages are recommended for women in child-bearing age.

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Association of body mass index and maternal age with first stage duration of labour

Scientific Reports ◽

10.1038/s41598-021-93217-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Louise Lundborg ◽

Xingrong Liu ◽

Katarina Åberg ◽

Anna Sandström ◽

Ellen L. Tilden ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Maternal Age ◽

Normal Weight ◽

The Body ◽

Younger Women ◽

Individualized Approach ◽

Quantile Regression Analysis ◽

Labour Time ◽

Group 1

AbstractTo evaluate associations between early-pregnancy body mass index (BMI) and active first stage labour duration, accounting for possible interaction with maternal age, we conducted a cohort study of women with spontaneous onset of labour allocated to Robson group 1. Quantile regression analysis was performed to estimate first stage labour duration between BMI categories in two maternal age subgroups (more and less than 30 years). Results show that obesity (BMI > 30) among younger women (< 30 years) increased the median labour duration of first stage by 30 min compared with normal weight women (BMI < 25), and time difference estimated at the 90th quantile was more than 1 h. Active first stage labour time differences between obese and normal weight women was modified by maternal age. In conclusion: (a) obesity is associated with longer duration of first stage of labour, and (b) maternal age is an effect modifier for this association. This novel finding of an effect modification between BMI and maternal age contributes to the body of evidence that supports a more individualized approach when describing labour duration.

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Prescriptive Reference Standards of Third-Trimester Cerebroplacental Ratio and Its Physiological Determinants

Fetal Diagnosis and Therapy ◽

10.1159/000508366 ◽

2020 ◽

Vol 47 (10) ◽

pp. 757-764

Author(s):

Marta Rial-Crestelo ◽

Laura Garcia-Otero ◽

Annalisa Cancemi ◽

Mariella Giannone ◽

Elena Escazzocchio ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Perinatal Outcomes ◽

Reference Standards ◽

Low Risk ◽

Maternal Body Mass Index ◽

Third Trimester ◽

Maternal Body ◽

Cerebroplacental Ratio ◽

Singleton Pregnancies

Objective: To construct valid reference standards reflecting optimal cerebroplacental ratio and to explore its physiological determinants. Methods: A cohort of 391 low-risk pregnancies of singleton pregnancies of nonmalformed fetuses without maternal medical conditions and with normal perinatal outcomes was created. Doppler measurements of the middle cerebral artery and umbilical artery were performed at 24–42 weeks. Reference standards were produced, and the influence of physiological determinants was explored by nonparametric quantile regression. The derived standards were validated in a cohort of 200 low-risk pregnancies. Results: Maternal body mass index was significantly associated with the 5th centile of the cerebroplacental ratio. For each additional unit of body mass index, the 5th centile was on average 0.014 lower. The derived 5th, 10th, and 50th centiles selected in the validation cohort were 5, 9.5, and 51% of the measurements. Conclusions: This study provides methodologically sound prescriptive standards and suggests that maternal body mass index is a determinant of a cutoff commonly used for decision-making.

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Association between maternal gestational weight gain and preterm birth according to body mass index and maternal age in Quzhou, China

Scientific Reports ◽

10.1038/s41598-020-72949-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Ying Hu ◽

Qi Wu ◽

Luyang Han ◽

Yuqing Zou ◽

Die Hong ◽

...

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Preterm Birth ◽

Gestational Weight Gain ◽

Body Mass ◽

Maternal Age ◽

Preterm Births ◽

Normal Weight ◽

Live Births ◽

Gestational Weight

Abstract The aim of this study is to investigate the association between maternal gestational weight gain (GWG) and preterm birth according to pre-pregnancy body mass index (BMI) and maternal age. We did a cohort, hospital-based study in Quzhou, South China, from 1 Jan 2018 to 30 June 2019. We selected 4274 singleton live births in our analysis, 315 (7.4%) of which were preterm births. In the overall population, excess GWG was significantly associated with a decreased risk of preterm birth compared with adequate GWG (adjusted OR 0.81 [95% CI 0.72–0.91]), and the risk varied by increasing maternal age and pre-pregnancy BMI. Interestingly, underweight women who older than 35 years with excess GWG had significantly increased odds of preterm birth compared with adequate GWG in underweight women aged 20–29 years (2.26 [1.06–4.85]) and normal weight women older than 35 years (2.23 [1.13–4.39]). Additionally, low GWG was positively and significantly associated with preterm birth overall (1.92 [1.47–2.50]). Among normal weight women category, compared with adequate GWG women aged 20–29 years did, those older than 20 years with low GWG, had significantly higher odds of preterm birth, which increased with maternal age (1.80 [1.16–2.79] in 20–29 years, 2.19 [1.23–3.91] in 30–34 years, 3.30 [1.68–6.46] in ≫ 35 years). In conclusion, maternal GWG was significantly associated with the risk of preterm birth, but the risk varied by pre-pregnancy BMI and maternal age.

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