142: Migraines in pregnancy and select adverse pregnancy outcomes

AbstractObjectivesTo compare the rate of fetal loss in pregnancy after second trimester amniocentesis between procedures performed by experts and non-experts and to assess other pregnancy complications as secondary outcomes.MethodsA retrospective cohort study was performed on singleton pregnancies that underwent mid-trimester amniocenteses in a single institution. The fetal loss rates of procedures performed by experts and non-experts were collected and analyzed. Other adverse pregnancy outcomes were also examined.ResultsIn total, 14,450 amniocenteses were performed during the study period. These included 11,357 (78.6%) procedures in the group expert operators and 3,093 (21.4%) procedures in the group non-expert operators. In the non-expert group, the fetal loss rate was slightly increased but not significantly (p=0.24).In addition, the higher number of spontaneous abortions was associated with blood-stained amniotic fluid sample (p<0.001; RR=9.28). Multiple needle insertions also increased in the non-expert group significantly. However, no difference in pregnancy outcomes was found between in single and multiple needle insertions.ConclusionsThe amniocentesis procedures performed by the non-experts was not increase the fetal loss rate. However, the other adverse pregnancy outcomes, including preterm birth, low birth weight and fetal growth restriction were significantly increased in the non-expert group.

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Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/j.1471-0528.2010.02742.x ◽

2010 ◽

Vol 117 (13) ◽

pp. 1593-1598 ◽

Cited By ~ 98

Author(s):

AW Shand ◽

N Nassar ◽

P Von Dadelszen ◽

SM Innis ◽

TJ Green

Keyword(s):

Vitamin D ◽

High Risk ◽

Pregnancy Outcomes ◽

Adverse Pregnancy Outcomes ◽

Vitamin D Status ◽

Maternal Vitamin ◽

Adverse Pregnancy ◽

Maternal Vitamin D Status ◽

In Pregnancy

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Schistosomiasis among pregnant women in the Njombe-Penja health district, Littoral region of Cameroon: A cross sectional study

10.1101/661900 ◽

2019 ◽

Author(s):

Calvin Tonga ◽

Charlie Ngo Bayoi ◽

Flore Chanceline Tchanga ◽

Jacqueline Félicité Yengue ◽

Godlove Bunda Wepnje ◽

...

Keyword(s):

Pregnant Women ◽

Pregnancy Outcomes ◽

Haemoglobin Concentration ◽

Epidemiological Data ◽

Adverse Pregnancy Outcomes ◽

Health District ◽

Blood Levels ◽

Childbearing Age ◽

Adverse Pregnancy ◽

In Pregnancy

AbstractBackgroundSchistosomiasis is a Neglected Tropical Disease with endemic foci in Cameroon. Epidemiological data on schistosomiasis in pregnancy are scarce in the country. This study is about schistosomiasis among pregnant women in the Njombe-Penja health district, where schistosomiasis was reported since 1969.MethodologyOverall, 282 pregnant women were enrolled upon informed consent at first antenatal consultation. A questionnaire was administered to document socio-economic and obstetric information. Stool and terminal urine samples were collected and analysed using the Kato-Katz/formol-ether concentration techniques and centrifugation method respectively. Haemoglobin concentration was measured with finger prick blood, using a URIT-12® electronic haemoglobinometer.Principal findingsThe overall prevalence of schistosomiasis was 31.91%. Schistosoma guineensis, S. haematobium and S. mansoni infections were found in 0.35%, 04.96% and 28.01% of participants respectively. Co-infection with 2 species of Schistosoma was found in 04.44% of these women. The prevalence of schistosomiasis was significantly higher in younger women (≤20) and among residents of Njombe. All S. haematobium infected women were anemic and infection was associated with significantly lower haemoglobin levels (p=0.02).ConclusionThe prevalence of schistosomiasis is high in pregnant women of the Njombe-Penja health district, with possible adverse pregnancy outcomes. Female of childbearing age should be considered for mass drug administration.Author summaryPregnant women are known to be more vulnerable to infectious diseases and in their case, at least two lives are at risk. Although schistosomiasis remains a major public health issue in Cameroon, epidemiological data on schistosomiasis in pregnancy are scarce. These data are of high interest for informed decision-making. We examined stools and urines from 282 women of the Njombe-Penja Health district and measured their blood levels. Overall, 31.91% of women were infected, mostly younger ones and those living in the town of Njombe. Three species of Schistosoma parasite were identified. Women having urinary schistosomiasis had lower blood levels. These results show that the prevalence of schistosomiasis is high in pregnant women of Njombe. Also, because of the anemia it induces, the disease can lead to adverse pregnancy outcomes on the woman and her foetus. Treating female of childbearing age would cure the disease and prevent adverse outcomes.

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The CRADLE-4 Trial: Can planned early birth in pre-eclampsia (high BP in pregnancy) reduce adverse pregnancy outcomes?

http://isrctn.com/ ◽

10.1186/isrctn10672137 ◽

2019 ◽

Author(s):

Alice Beardmore-Gray ◽

Andrew Shennan

Keyword(s):

Pregnancy Outcomes ◽

Adverse Pregnancy Outcomes ◽

Adverse Pregnancy ◽

In Pregnancy

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Is Periodontal Disease in Pregnancy Associated with Adverse Pregnancy Outcomes?

Journal of Gynecology and Womens Health ◽

10.19080/jgwh.2017.06.555699 ◽

2017 ◽

Vol 6 (5) ◽

Author(s):

Irosha Rukmali Perera

Keyword(s):

Periodontal Disease ◽

Pregnancy Outcomes ◽

Adverse Pregnancy Outcomes ◽

Adverse Pregnancy ◽

In Pregnancy

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Abstract MP096: Patterns of Physical Activity Across Pregnancy and Their Association With Adverse Pregnancy Outcomes

Circulation ◽

10.1161/circ.135.suppl_1.mp096 ◽

2017 ◽

Vol 135 (suppl_1) ◽

Author(s):

Janet M Catov ◽

Corette B Parker ◽

Bethany B Gibbs ◽

Carla Bann ◽

Benjamin Carper ◽

...

Keyword(s):

Physical Activity ◽

Pregnancy Outcomes ◽

Activity Patterns ◽

Growth Mixture Modeling ◽

Adverse Pregnancy Outcomes ◽

Metabolic Equivalents ◽

Nulliparous Women ◽

Adverse Pregnancy ◽

Low Activity ◽

In Pregnancy

Background: Cardiovascular disease (CVD) is the leading cause of death among women, and pregnancy complications reveal risk decades before overt CVD. While physical activity is related to CVD, less is known about how the activity patterns during pregnancy may contribute to adverse pregnancy outcomes. Hypothesis: Increasing activity across pregnancy is related to reduced risk of adverse pregnancy outcomes. Methods: Nulliparous women were enrolled at 8 centers early in pregnancy (n=10,020). Frequency and duration of up to three leisure activities reported in the first, second and third trimester were analyzed as metabolic equivalents (METs). Growth mixture modeling was used to identify activity patterns in pregnancy. Adverse outcomes (preterm birth [PTB], hypertensive disease of pregnancy [HDP], and gestational diabetes [GDM]) were collected by chart abstraction. Results: Four patterns of activity across pregnancy were identified: sustained high (3%, n=297); increasing (12%, n=1231); sustained low (77%, n=7717); and decreasing (8%, n=775; Figure). Women with sustained low activity were younger and more likely to be black or Hispanic, obese, or to have smoked prior to pregnancy when compared to those with increasing activity. Women with sustained low vs. increasing activity had higher rates of PTB (9.2 vs. 6.2%), HDP (13.8 vs. 10.5%), and GDM (4.7 vs. 2.5%; all p <0.01). After adjusting for maternal factors (age, race/ethnicity, BMI and smoking), the risk of GDM remained higher in women with sustained low activity compared with those having increasing activity patterns (adjusted OR 1.79 [1.21, 2.66]). Sustained low activity was also associated with higher risk of PTB (adjusted OR 1.36 [1.05, 1.76]). Conclusion: The majority of women have sustained low activity across pregnancy, and this is independently associated with higher risks of GDM and PTB. These associations raise the possibility that increased activity during pregnancy may improve pregnancy outcomes, and perhaps long-term maternal cardiovascular health.

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Low maternal weight, failure to thrive in pregnancy, and adverse pregnancy outcomes

American Journal of Obstetrics and Gynecology ◽

10.1016/s0002-9378(03)00860-3 ◽

2003 ◽

Vol 189 (6) ◽

pp. 1726-1730 ◽

Cited By ~ 142

Author(s):

Hugh M Ehrenberg ◽

LeRoy Dierker ◽

Cynthia Milluzzi ◽

Brian M Mercer

Keyword(s):

Pregnancy Outcomes ◽

Failure To Thrive ◽

Adverse Pregnancy Outcomes ◽

Maternal Weight ◽

Adverse Pregnancy ◽

In Pregnancy

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The safety of isoniazid tuberculosis preventive treatment in pregnant and postpartum women: systematic review and meta-analysis

European Respiratory Journal ◽

10.1183/13993003.01967-2019 ◽

2020 ◽

Vol 55 (3) ◽

pp. 1901967

Author(s):

Yohhei Hamada ◽

Carmen Figueroa ◽

Mario Martín-Sánchez ◽

Dennis Falzon ◽

Avinash Kanchar

Keyword(s):

Pregnant Women ◽

Pregnancy Outcomes ◽

Current Knowledge ◽

Preventive Treatment ◽

Adverse Pregnancy Outcomes ◽

World Health ◽

Current Evidence ◽

Drug Discontinuation ◽

Adverse Pregnancy ◽

In Pregnancy

BackgroundThe World Health Organization (WHO) recommends tuberculosis (TB) preventive treatment for high-risk groups. Isoniazid preventive therapy (IPT) has been used globally for this purpose for many years, including in pregnancy. This review assessed current knowledge about the safety of IPT in pregnancy.MethodsWe searched PubMed, Embase, CENTRAL, Global Health Library and HIV and TB-related conference abstracts, until May 15, 2019, for randomised controlled trials (RCTs) and non-randomised studies (NRS) where IPT was administered to pregnant women. Outcomes of interest were: 1) maternal outcomes, including permanent drug discontinuation due to adverse drug reactions, any grade 3 or 4 drug-related toxic effects, death from any cause and hepatotoxicity; and 2) pregnancy outcomes, including in utero fetal death, neonatal death or stillbirth, preterm delivery/prematurity, intrauterine growth restriction, low birth weight and congenital anomalies. Meta-analyses were conducted using a random-effects model.ResultsAfter screening 1342 citations, nine studies (of 34 to 51 942 participants) met inclusion criteria. We found an increased likelihood of hepatotoxicity among pregnant women given IPT (risk ratio 1.64, 95% CI 0.78–3.44) compared with no IPT exposure in one RCT. Four studies reported on pregnancy outcomes comparing IPT exposure to no exposure among pregnant women with HIV. In one RCT, adverse pregnancy outcomes were associated with IPT exposure during pregnancy (odds ratio (OR) 1.51, 95% CI 1.09–2.10), but three NRS showed a protective effect.ConclusionsWe found inconsistent associations between IPT and adverse pregnancy outcomes. Considering the grave consequences of active TB in pregnancy, current evidence does not support systematic deferral of IPT until postpartum. Research on safety is needed.

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