710 Mid-gestation cervicovaginal cytokines correlate with gestational age at delivery in women with prior preterm birth

Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

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Placental malperfusion as a possible mechanism of preterm birth in patients with Müllerian anomalies

Journal of Perinatal Medicine ◽

10.1515/jpm-2016-0075 ◽

2017 ◽

Vol 45 (1) ◽

Cited By ~ 6

Author(s):

Jovana Lekovich ◽

Joshua Stewart ◽

Sarah Anderson ◽

Erin Niemasik ◽

Nigel Pereira ◽

...

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Placenta Previa ◽

Preterm Births ◽

Mullerian Anomalies ◽

Müllerian Anomalies ◽

Increased Risk ◽

Uterine Anomalies ◽

Gestational Age At Delivery ◽

Term Births

AbstractObjective:Müllerian anomalies are associated with increased risk of miscarriage, intrauterine growth restriction (IUGR) and preterm birth. While a commonly implicated cause is restricted expansion of endometrial cavity, alternatively it could be due to abnormal placentation. We sought to examine clinical and histopathologic factors associated with preterm delivery in women with Müllerian anomalies.Study design:One hundred and eleven singleton pregnancies in 85 women were analyzed retrospectively. There were 42 pregnancies with bicornaute, 24 with unicornuate, 24 with septate, 19 with didelphys and one each with arcuate and T-shaped uterus. Primary outcomes included gestational age at delivery, placental histopathology, placenta previa and accreta.Results:Twenty-eight (25.2%) of pregnancies were delivered prior to term. Of those, only 14 (50%) were due to preterm labor or preterm premature rupture of membranes (PPROM). Histological evidence of placental malperfusion was present in 22% of all pregnancies and those delivered at an earlier median gestational age [34 (IQR 31–37) vs. 37 weeks (IQR 34–39); P=0.001]. Malperfusion was more common in preterm than in full term births (46% vs. 14%; P=0.04). Conversely, inflammation was not more common in preterm compared to term deliveries (17.9% vs. 16.9%; P=0.89). Five pregnancies had placenta previa, three of which were complicated by accreta.Conclusion:Placental malperfusion, rather than inflammation, was more commonly associated with preterm births in women with uterine anomalies.

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Maternal obesity classes, preterm and post-term birth: a retrospective analysis of 479,864 births in England

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2585-z ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 4

Author(s):

Emma Slack ◽

Kate E. Best ◽

Judith Rankin ◽

Nicola Heslehurst

Keyword(s):

Preterm Birth ◽

Retrospective Analysis ◽

Gestational Age ◽

Maternal Obesity ◽

Absolute Risk ◽

Full Term ◽

Effect Sizes ◽

Term Birth ◽

Gestational Age At Delivery ◽

Maternal Bmi

Abstract Background Preterm (< 37 weeks gestation) and post–term birth (≥42 weeks gestation) are associated with increased morbidity and mortality for mother and infant. Obesity (body mass index (BMI) ≥30 kg/m2) is increasing in women of reproductive age. Maternal obesity has been associated with adverse pregnancy outcomes including preterm and post–term birth. However, the effect sizes vary according to the subgroups of both maternal BMI and gestational age considered. The aim of this retrospective analysis was to determine the association between maternal obesity classes and gestational age at delivery. Methods A secondary data analysis of 13 maternity units in England with information on 479,864 singleton live births between 1990 and 2007. BMI categories were: underweight (< 18.5 kg/m2), recommended weight (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2) and obesity classes I (30.0–34.9 kg/m2), II (35.0–39.9 kg/m2), IIIa (40–49.9 kg/m2) and IIIb (≥50 kg/m2). Gestational age at delivery categories were: Gestational age at delivery (weeks): extreme preterm (20–27), very preterm (28–31), moderately preterm (32–36), early term (37, 38), full term (39–40), late term (41) and post–term (≥42). The adjusted odds of births in each gestational age category (compared to full-term birth), according to maternal BMI categories were estimated using multinomial logistic regression. Missing data were estimated using multiple imputation with chained equations. Results There was a J-shaped association between the absolute risk of extreme, very and moderate preterm birth and BMI category, with the greatest effect size for extreme preterm. The absolute risk of post-term birth increased monotonically as BMI category increased. The largest effect sizes were observed for class IIIb obesity and extreme preterm birth (adjusted OR 2.80, 95% CI 1.31–5.98). Conclusion Women with class IIIb obesity have the greatest risks for inadequate gestational age. Combining obesity classes does not accurately represent risks for many women as it overestimates the risk of all preterm and post-term categories for women with class I obesity, and underestimates the risk for women in all other obesity classes.

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Antenatal Azithromycin to Prevent Preterm Birth in Pregnant women with Vaginal Cerclage. A Randomized Controlled Trial

QJM ◽

10.1093/qjmed/hcab115.037 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Rania Hassan Mostafa ◽

Sherif Ahmed Ashoush ◽

Hassan Awwad Bayoumy ◽

Wessam Kamal Lotfy Gabr

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Antenatal Care ◽

Gestational Age ◽

Mode Of Delivery ◽

Perinatal Morbidity ◽

Randomized Controlled ◽

Significant Difference ◽

Gestational Age At Delivery

Abstract Background Preterm birth with its complications is one of the leading causes of perinatal morbidity and mortality, as well as maternal morbidity, especially in low and middle-income countries. Cervical cerclage is a well-established preventive tool in women at high risk of preterm birth; however, subclinical maternal infection might still cause failure of this method. Thus, adding prophylactic antibiotics, namely macrolides, could prevent preterm birth. Patients and methods This was a randomized controlled clinical trial involving two groups of women who underwent vaginal cerclage at Ain Shams University Maternity Hospital. One group received azithromycin 500mg one tablet orally once daily for 3 days every month from 14th week to 34th week gestation, in addition to routine antenatal care; while the other group received usual antenatal care without antibiotic prophylaxis after cerclage. Follow-up was done and we compared the outcomes in each group: gestational age at delivery, birth weight, mode of delivery, maternal complications, and perinatal complications. ClinicalTrials.gov Identifier NCT04278937. Results Gestational age at delivery was significantly higher in the azithromycin group (36.8weeks vs 34.1weeks; P = 0.017), with significant prolongation of gestation in the azithromycin group (23.7weeks vs 21.1weeks; P = 0.005). As regards birth weight, it was significantly higher in the azithromycin group (2932.6gm vs 2401.8gm; P = 0.006); however babies with low birth weight (birth weight <2500gm) were non-significantly less frequent in the azithromycin group (3cases vs 7cases; P = 0.165). There was no significant difference between the two groups as regards other outcomes (miscarriage, stillbirth, neonatal intensive care unit admission, antepartum hemorrhage, postpartum pyrexia, need for blood transfusion). Conclusion Adding azithromycin as antenatal prophylaxis in women undergoing vaginal cerclage prolongs pregnancy and reduces risk of PTB, with slight increase in birth weight. However, there was no clear effect on incidence of low birth weight, or perinatal morbidity/mortality.

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Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes

Journal of Perinatal Medicine ◽

10.1515/jpm-2015-0123 ◽

2016 ◽

Vol 44 (5) ◽

Cited By ~ 4

Author(s):

Joohee Choi ◽

Jeong Woo Park ◽

Byoung Jae Kim ◽

Ye-Jin Choi ◽

Jong Hee Hwang ◽

...

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Preterm Labor ◽

Cervical Insufficiency ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Histologic Chorioamnionitis ◽

Gestational Age At Delivery ◽

The Difference

AbstractTo compare the frequency of histologic chorioamnionitis and funisitis among women experiencing preterm labor, preterm premature rupture of membranes (PROM) and cervical insufficiency.This retrospective cohort study included singleton pregnant women who delivered at ≤36 weeks of gestation. The patients with preterm birth were subdivided into preterm labor (n=117), preterm PROM (n=153), and cervical insufficiency (n=20). All placentas were examined for pathology, according to the criteria of1) Histologic chorioamnionitis was diagnosed in 48.7% (57/117) of cases with preterm labor, 47.4% (73/153) with preterm PROM, and 75.0% (15/20) with cervical insufficiency. Funisitis was detected in 11.1% (13/117) of cases with preterm labor, 15.7% (24/153) with preterm PROM, and 40.0% (8/20) with cervical insufficiency. 2) Frequency of histologic chorioamnionitis was higher in cases with cervical insufficiency compared to preterm PROM. Frequency of funisitis was higher in cases with cervical insufficiency compared to both preterm labor and preterm PROM (P<0.05). The difference in frequency of funisitis remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis. 3) Frequency of grade 2 funisitis was higher in cases with cervical insufficiency (35.0%, 7/20) compared to both preterm labor (6.8%, 8/117) and preterm PROM (9.8%, 15/153) (P=0.001). And the difference remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis.: The highest frequency of funisitis was observed in cervical insufficiency among cases with spontaneous preterm birth.

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755: Does mid-trimester Nugent score or vaginal pH predict gestational age at delivery in women at risk for preterm birth?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2008.09.786 ◽

2008 ◽

Vol 199 (6) ◽

pp. S215 ◽

Cited By ~ 4

Author(s):

Dana Figueroa ◽

Melissa Mancuso ◽

Merri Maddox Paden ◽

Jeff Szychowski ◽

John Owen

Keyword(s):

At Risk ◽

Preterm Birth ◽

Gestational Age ◽

Nugent Score ◽

Vaginal Ph ◽

Gestational Age At Delivery

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Procedure-Related Complications and Survival Following Fetoscopic Endotracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia: Systematic Review and Meta-Analysis in the FETO Era

European Journal of Pediatric Surgery ◽

10.1055/s-0036-1587331 ◽

2016 ◽

Vol 27 (04) ◽

pp. 297-305 ◽

Cited By ~ 10

Author(s):

Gabriele Tonni ◽

Wellington Martins ◽

Rodrigo Ruano ◽

Edward Araujo Júnior

Keyword(s):

Systematic Review ◽

Preterm Birth ◽

Relative Risk ◽

Gestational Age ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Premature Rupture ◽

Level Of Evidence ◽

Gestational Age At Delivery

Introduction This study aims to assess the procedure-related complications and survival following fetoscopic endotracheal occlusion (FETO) for severe congenital diaphragmatic hernia. Materials and Methods A systematic review and meta-analysis of PubMed and Scopus database searching for FETO procedure in severe CDH (lung-to-head ratio [LHR] < 1.0 and/or observed/expected LHR < 0.26 and > 1/3 liver herniation) were performed. The relative risk was assessed and 95% confidence interval (CI) calculated. Procedure complications and survival were compared between FETO and randomized controlled trial (RCT) as well as observational case–control studies. Results A total of 4,807 records were retrieved based on the title and abstracts, and 18 studies were eligible for statistical analysis (1 RCT and 17 observational case–control studies). Relative risk (95% CI) comparing FETO and controls for premature rupture of membrane, preterm birth < 32 weeks, preterm birth < 37 weeks, survival at 30 days, and survival at 6 months were 1.7 (0.8–2.4), 7.3 (0.4–134), 1.8 (0.8–3.9), 5.8 (1.5–22.9), and 10.5 (1.5–74.7), respectively. Mean difference (95% CI) for gestational age at delivery comparing FETO and controls was 1.8 (−3.1 to −0.5). All these outcomes showed a low level of evidence. Conclusion FETO procedure increased the neonatal survival at 30 days and 6 months; however, it presented a higher rate of premature rupture of membrane, preterm birth < 37 weeks, and decreased the gestational age at delivery by 2 weeks. Nonetheless, the level of evidence is low for all these outcomes. We suggested a large international multicenter RCT to prove the real benefits of FETO.

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533: Racial differences in gestational age at delivery in a transgenerational preterm birth cohort

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2016.11.268 ◽

2017 ◽

Vol 216 (1) ◽

pp. S314-S315

Author(s):

Marcela Carolina Smid ◽

Jon Lee ◽

Derek Chapman ◽

Gregory J. Stoddard ◽

Gandarvaka Miles ◽

...

Keyword(s):

Preterm Birth ◽

Birth Cohort ◽

Racial Differences ◽

Gestational Age ◽

Gestational Age At Delivery

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Measurement of the uterocervical angle for the prediction of preterm birth in symptomatic women

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-021-06002-0 ◽

2021 ◽

Author(s):

Philipp Wagner ◽

Jana Schlechtendahl ◽

Markus Hoopmann ◽

Natalia Prodan ◽

Harald Abele ◽

...

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Cervical Length ◽

University Hospital ◽

Second Line ◽

Uterine Contractions ◽

Gestational Age At Delivery ◽

The University ◽

Time Of Presentation ◽

Singleton Pregnancies

Abstract Purpose To examine if the uterocervical angle (UCA) can be used to predict preterm delivery in women with painful and regular uterine contractions and a cervical length of 25 mm or less. Methods Retrospective study at the perinatal unit of the University Hospital of Tuebingen, Germany. Women with singleton gestation and preterm contractions between 24 + 0 and 33 + 6 weeks’ gestation were included. For the UCA measurement, a line is placed from the internal os to the external os irrespective of whether the cervix is straight or curved. A second line is drawn to delineate the lower uterine segment. The angle between the two lines is the UCA measurement. The measurements were taken on stored images from our database. Results The study consisted of 213 singleton pregnancies. At the time of UCA measurement, median maternal and gestational age was 31.4 years and 29.7 weeks’ gestation. Median gestational age at delivery was 35.3 weeks and the corresponding birth weight 2480 g, respectively. The UCA measurement in women who delivered within 2 days, between 3–7 days and after 7 days was not helpful to distinguish between these three groups [median UCA measurements: 108.5°, 108.0° and 107.3° (Kruskal–Wallis test p = 0.576)]. Uni- and multivariate logistic multiple regression analysis demonstrated that the delivery within 2 days was only dependent on the gestational age and the cervical length at the time of presentation. Conclusion The measurement of UCA is not useful in predicting preterm birth in the subsequent 7 days after an episode of preterm contractions.

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Vaginal progesterone supplementation in the management of preterm labor: A randomized controlled trial

10.21203/rs.2.23972/v1 ◽

2020 ◽

Author(s):

Ratanawadee Sirisangwon ◽

Vorapong Phupong

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Preterm Labor ◽

Distress Syndrome ◽

Controlled Trial ◽

Latency Period ◽

Antenatal Corticosteroids ◽

Randomized Controlled ◽

Vaginal Progesterone ◽

Gestational Age At Delivery

Abstract BackgroundPreterm labor is a common obstetric complication and can lead to preterm delivery. Preterm birth or preterm delivery is the leading cause of neonatal morbidity and mortality, especially when preterm birth occurs at a gestational age less than 34 weeks. The primary objective in this study was to evaluate the effects of vaginal progesterone supplementation for the prolongation of the latency period in preterm labor. The secondary objectives were to evaluate gestational age at delivery, rates of preterm birth less than 34 and 37 weeks, obstetric outcomes, maternal compliance with medication use, and side effects.MethodsA randomized controlled trial was performed. Ninety women with preterm labor occurring at 24 to 34 weeks were either randomized to a vaginal progesterone group (44 women) receiving tocolytic and antenatal corticosteroids treatment combined with vaginal micronized progesterone (400 mg everyday) or to the no-progesterone group (46 women) receiving tocolytic and antenatal corticosteroids treatment only.ResultsLatency periods were more prolonged in the vaginal progesterone group than in the no-progesterone group (32.8 ± 18.7 vs. 25.8 ± 22.7 days, p = 0.045). Gestational age at delivery in the vaginal progesterone group was also higher than in the no-progesterone group (36.5 ± 2.9 vs. 34.9 ± 3.7 weeks, p = 0.022). There were significant reduction rates of preterm birth less than 34 weeks (13.6% vs. 39.1%, p = 0.012), low birth weight (29.5% vs. 50%, p = 0.048), neonatal respiratory distress syndrome (13.6% vs. 37%, p=0.021), and neonatal intensive care unit admission (6.8% vs. 28.3%, p = 0.017).ConclusionCombined treatment with vaginal progesterone 400 mg could prolong the latency period in preterm labor when compared with no progesterone. Further, this approach could decrease the rates of preterm birth less than 34 weeks, low birth weight, and neonatal respiratory distress syndrome.

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