Validation of ICD-10-CM Diagnosis Codes for Gestational Age at Birth

Atypical coeliac disease in young children is frequently missed when it presents atypically as non-gastrointestinal presentations to different specialties. There was a greater delay (54 months) in establishing the diagnosis in those with atypical coeliac disease (p < 0.001). No difference was observed in the mode of delivery or duration of breast feeding, but significant difference was observed between gestational age at birth (p < 0.001). Most cases showed stunted growth and underweight. Irritability, anaemia, rickets, dermatitis herpetiformis, alopecia and intussusception were other common predictors of atypical coeliac disease. Because of a myriad spectrum of non-gastrointestinal symptoms, at any age with diverse presentation, a high index of suspicion is therefore required.

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Maternal biological age assessed in early pregnancy is associated with gestational age at birth

Scientific Reports ◽

10.1038/s41598-021-94281-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Eva E. Lancaster ◽

Dana M. Lapato ◽

Colleen Jackson-Cook ◽

Jerome F. Strauss ◽

Roxann Roberson-Nay ◽

...

Keyword(s):

Risk Factors ◽

Preterm Birth ◽

Early Pregnancy ◽

Gestational Age ◽

Cellular Aging ◽

Biological Age ◽

Potential Candidate ◽

A Genome ◽

Gestational Age At Birth ◽

Age At Birth

AbstractMaternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic background and environmental exposures. As a result, there is a need to identify biomarkers that more closely index the rate of cellular aging. One potential candidate is biological age (BA) estimated by the DNA methylome. This study investigated whether maternal BA, estimated in either early and/or late pregnancy, predicts gestational age at birth. BA was estimated from a genome-wide DNA methylation platform using the Horvath algorithm. Linear regression methods assessed the relationship between BA and pregnancy outcomes, including gestational age at birth and prenatal perceived stress, in a primary and replication cohort. Prenatal BA estimates from early pregnancy explained variance in gestational age at birth above and beyond the influence of other recognized preterm birth risk factors. Sensitivity analyses indicated that this signal was driven primarily by self-identified African American participants. This predictive relationship was sensitive to small variations in the BA estimation algorithm. Benefits and limitations of using BA in translational research and clinical applications for preterm birth are considered.

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512: Are appropriately sized fetuses who “fall off the curve” at increased risk for small-for-gestational age at birth?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2017.11.038 ◽

2018 ◽

Vol 218 (1) ◽

pp. S306-S307

Author(s):

Nathan R. Blue ◽

Mariam Savabi ◽

Meghan E. Beddow ◽

Vivek R. Katukuri ◽

Cody M. Fritts ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Increased Risk ◽

Gestational Age At Birth ◽

Age At Birth

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Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis

PLoS Medicine ◽

10.1371/journal.pmed.1001865 ◽

2015 ◽

Vol 12 (8) ◽

pp. e1001865 ◽

Cited By ~ 65

Author(s):

Ge Zhang ◽

Jonas Bacelis ◽

Candice Lengyel ◽

Kari Teramo ◽

Mikko Hallman ◽

...

Keyword(s):

Causal Relationship ◽

Gestational Age ◽

Mendelian Randomization ◽

Birth Size ◽

Maternal Height ◽

Mendelian Randomization Analysis ◽

Gestational Age At Birth ◽

Relationship Of ◽

Randomization Analysis ◽

Age At Birth

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Cost of neonatal care according to gestational age at birth and survival status

American Journal of Obstetrics and Gynecology ◽

10.1016/s0002-9378(00)70509-6 ◽

2000 ◽

Vol 182 (1) ◽

pp. 170-175 ◽

Cited By ~ 87

Author(s):

Elaine B. St. John ◽

Kathleen G. Nelson ◽

Suzanne P. Cliver ◽

Rita R. Bishnoi ◽

Robert L. Goldenberg

Keyword(s):

Gestational Age ◽

Neonatal Care ◽

Survival Status ◽

Gestational Age At Birth ◽

Age At Birth

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Gestational Age at Birth and Outcomes After Neonatal Cardiac Surgery

Circulation ◽

10.1161/circulationaha.113.005864 ◽

2014 ◽

Vol 129 (24) ◽

pp. 2511-2517 ◽

Cited By ~ 74

Author(s):

John M. Costello ◽

Sara K. Pasquali ◽

Jeffrey P. Jacobs ◽

Xia He ◽

Kevin D. Hill ◽

...

Keyword(s):

Cardiac Surgery ◽

Gestational Age ◽

Neonatal Cardiac Surgery ◽

Gestational Age At Birth ◽

Age At Birth

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Twin Pregnancies Complicated by a Single Malformed Fetus: Chorionicity, Outcome and Management

Twin Research and Human Genetics ◽

10.1375/twin.13.5.501 ◽

2010 ◽

Vol 13 (5) ◽

pp. 501-507 ◽

Cited By ~ 8

Author(s):

Ali Gedikbasi ◽

Alpaslan Akyol ◽

Gokhan Yildirim ◽

Ali Ekiz ◽

Ahmet Gul ◽

...

Keyword(s):

Gestational Age ◽

Statistical Significance ◽

Expectant Management ◽

Control Group ◽

Study Group ◽

Preliminary Evaluation ◽

Gestational Age At Birth ◽

The Impact ◽

Twin Pregnancies ◽

Age At Birth

The objective of this study was to evaluate the impact of one abnormal fetus in a twin pregnancy, to compare impact of chorionicity and clinical outcome of intervention and expectant management. Thirty-seven dichorionic (DC) twins and 18 monochorionic (MC) twins complicated with one malformed fetus were evaluated for gestational age, birthweight and perinatal outcome. Six hundred and forty-two twin pregnancies were evaluated in the database. The control groups consisted of 429 DC and 86 MC twins without anomalous fetus. Mean birthweight and gestational age at birth for DC control group were (n= 429; 2137g and 34.71 weeks), DC study group,n= 37; 2117g (p= .338) and 33.97 weeks (p= .311), and DC study group with major malformations,n= 30; 2019g (p= .289) and 33.3 weeks (p= .01), and showed only significance for gestational age. There was no statistical significance between MC control group,n= 86; 2097g and 34.93 weeks, and MC study group,n= 18; 2237g (p= .338), and 34.42 weeks (p= .502). Because of limited data, the preliminary evaluation for expectant management and intervention, and survival of at least one normal fetus showed no impact. We conclude that, although, all DC twin pregnancies have a risk for preterm delivery, DC twins complicated with major malformation of one twin, have a lower mean gestational age at birth. Preliminary results for intervention does not improve fetal outcome for DC and MC twins and needs further evaluation with greater studies of impact or review.

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