scholarly journals Heterogeneity in Cardio-Metabolic Risk Factors and Atherosclerotic Cardiovascular Disease Among Asian Groups in the United States

2021 ◽  
pp. 100219
Author(s):  
Priyanka Satish ◽  
Murrium I. Sadaf ◽  
Javier Valero-Elizondo ◽  
Gowtham R. Grandhi ◽  
Tamer Yahya ◽  
...  
Keyword(s):  
United States ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
The United States ◽  
Metabolic Risk Factors ◽  
Atherosclerotic Cardiovascular Disease ◽  
Metabolic Risk

Abstract 37: Metabolomic Signatures of Metabolic Risk Factors for Atherosclerotic Cardiovascular Disease

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Xiaoyan Yin ◽  
Shih-Jen Hwang ◽  
Aram Adourian ◽  
Paul Courchesne ◽  
Neal Gordon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Glutamic Acid ◽  
Metabolic Risk Factors ◽  
Individual Risk ◽  
Atherosclerotic Cardiovascular Disease ◽  
Metabolic Risk ◽  
Sample Mean ◽  
Total N ◽  
Main Effects

Background: Multiple cardiovascular disease (CVD) risk factors cluster in the same individuals and their concurrence is used to diagnose metabolic syndrome (MetSyn), which carries substantial risk for CVD. We hypothesized that MetSyn is associated with multiple metabolomic derangements. Methods: As part of the SABRe CVD initiative, a multi-project investigation of biomarkers of CVD and its risk factors, we designed a 2x2x2 factorial study of MetSyn risk factors that included 650 individuals from the Framingham Heart Study (out of a total N of ∼3200) assigned to 8 unique groups of approximately 81 individuals each, sampled from high vs. low strata of BMI, lipids, and glucose. We conducted gas chromatography-mass spectroscopy (GC/MS) on plasma samples from 650 eligible individuals. General linear modeling was used to identify biomarkers that differed across all 8 groups or differed in their main effects on individual risk factors. Results: Characteristics of the study sample (mean±SD), according to group assignment, are presented in the Table. GC/MS characterized 149 metabolites; of these 18 differed across all groups at P<5x10 -8 and 36 differed at P<0.00001. The top 3 most highly significant metabolites across all groups were glucose (P=2x10 -40 ), glutamic acid (P=4x10 -26 ), and sphingomyelins (lowest P=8x10 -25 ). The top 3 most highly significant main effects of metabolites for BMI were: glutamic acid (P=2x10 -18 ), sitosterol (P=2x10 -10 ), and uric acid (P=3x10 -10 ), for dyslipidemia: sphingomyelins (lowest P=1x10 -27 ), glutamic acid (P=5x10 -20 ), and lactic acid (P=7x10 -12 ), and for dysglycemia: glucose (P=1x10 -42 ), fructose (P=3x10 -7 ), and 2-hydroxybutanoic acid (P=6x10 -7 ). Conclusions: Metabolomic profiling identified multiple biomarker signatures of MetSyn and its major metabolic risk factors. These novel findings warrant external replication. Understanding the pathways represented by our results may help to unravel the molecular derangements contributing to MetSyn and its constituent risk factors. This knowledge may identify therapeutic targets for the prevention and treatment of CVD.

scholarly journals Dietary Patterns Are Associated with Metabolic Risk Factors in South Asians Living in the United States

2015 ◽  
Vol 145 (6) ◽  
pp. 1211-1217 ◽  
Author(s):  
Meghana D Gadgil ◽  
Cheryl AM Anderson ◽  
Namratha R Kandula ◽  
Alka M Kanaya
Keyword(s):  
United States ◽  
Risk Factors ◽  
Dietary Patterns ◽  
South Asians ◽  
The United States ◽  
Metabolic Risk Factors ◽  
Metabolic Risk

scholarly journals The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors

PLoS Medicine ◽  
2009 ◽  
Vol 6 (4) ◽  
pp. e1000058 ◽  
Author(s):  
Goodarz Danaei ◽  
Eric L. Ding ◽  
Dariush Mozaffarian ◽  
Ben Taylor ◽  
Jürgen Rehm ◽  
...  
Keyword(s):  
United States ◽  
Risk Factors ◽  
Risk Assessment ◽  
Causes Of Death ◽  
The United States ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Comparative Risk Assessment ◽  
Comparative Risk

scholarly journals Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease

Diabetologia ◽  
1997 ◽  
Vol 40 (10) ◽  
pp. 1178-1184 ◽  
Author(s):  
C. Couillard ◽  
P. Mauriège ◽  
D. Prud'homme ◽  
A. Nadeau ◽  
A. Tremblay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Gender Differences ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Plasma Leptin

Cardiovascular Disease Risk Factors Among Immigrant and US-Born Adults in New York City

2021 ◽  
pp. 003335492110075
Author(s):  
Claudia Chernov ◽  
Lisa Wang ◽  
Lorna E. Thorpe ◽  
Nadia Islam ◽  
Amy Freeman ◽  
...  
Keyword(s):  
United States ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
New York ◽  
New York City ◽  
Health Insurance ◽  
York City ◽  
The United States ◽  
Nutrition Examination Survey ◽  
Health And Nutrition

Objectives Immigrant adults tend to have better health than native-born adults despite lower incomes, but the health advantage decreases with length of residence. To determine whether immigrant adults have a health advantage over US-born adults in New York City, we compared cardiovascular disease (CVD) risk factors among both groups. Methods Using data from the New York City Health and Nutrition Examination Survey 2013-2014, we assessed health insurance coverage, health behaviors, and health conditions, comparing adults ages ≥20 born in the 50 states or the District of Columbia (US-born) with adults born in a US territory or outside the United States (immigrants, following the National Health and Nutrition Examination Survey) and comparing US-born adults with (1) adults who immigrated recently (≤10 years) and (2) adults who immigrated earlier (>10 years). Results For immigrant adults, the mean time since arrival in the United States was 21.8 years. Immigrant adults were significantly more likely than US-born adults to lack health insurance (22% vs 12%), report fair or poor health (26% vs 17%), have hypertension (30% vs 23%), and have diabetes (20% vs 11%) but significantly less likely to smoke (18% vs 27%) (all P < .05). Comparable proportions of immigrant adults and US-born adults were overweight or obese (67% vs 63%) and reported CVD (both 7%). Immigrant adults who arrived recently were less likely than immigrant adults who arrived earlier to have diabetes or high cholesterol but did not differ overall from US-born adults. Conclusions Our findings may help guide prevention programs and policy efforts to ensure that immigrant adults remain healthy.

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