Beneficial effects of erythropoietin on airway histology in a murine model of chronic asthma

2012 ◽  
Vol 40 (2) ◽  
pp. 75-80 ◽  
Author(s):  
M. Karaman ◽  
F. Firinci ◽  
M. Kiray ◽  
T. Tuncel ◽  
A. Bagriyanik ◽  
...  
Keyword(s):  
Murine Model ◽  
Chronic Asthma ◽  
Beneficial Effects

Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma

2014 ◽  
Vol 42 (4) ◽  
pp. 316-323 ◽  
Author(s):  
Z. Arıkan-Ayyıldız ◽  
M. Karaman ◽  
T. Tuncel ◽  
M. Kiray ◽  
A. Bağrıyanık ◽  
...  
Keyword(s):  
Murine Model ◽  
Chronic Asthma ◽  
Beneficial Effects

Neutralizing IgE Prevents Airway Remodeling In A Murine Model Of Chronic Asthma

2010 ◽  
Author(s):  
Hironori Sagara ◽  
Hiroyuki Masuda ◽  
Mayumi Ota ◽  
Takenori Okada ◽  
Kazumi Akimoto ◽  
...  
Keyword(s):  
Murine Model ◽  
Airway Remodeling ◽  
Chronic Asthma

scholarly journals Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia

2019 ◽  
Vol 220 (9) ◽  
pp. 1498-1502 ◽  
Author(s):  
Zhiping Yang ◽  
Alice Bedugnis ◽  
Susan Levinson ◽  
Mark Dinubile ◽  
Thomas Stossel ◽  
...  
Keyword(s):  
Weight Loss ◽  
Antimicrobial Resistance ◽  
Mouse Model ◽  
Murine Model ◽  
Pneumococcal Pneumonia ◽  
Preclinical Models ◽  
Antibiotic Resistant ◽  
Plasma Gelsolin ◽  
Beneficial Effects ◽  
Serious Infections

Abstract Therapy to enhance host immune defenses may improve outcomes in serious infections, especially for antibiotic-resistant pathogens. Recombinant human plasma gelsolin (rhu-pGSN), a normally circulating protein, has beneficial effects in diverse preclinical models of inflammation and injury. We evaluated delayed therapy (24–48 hours after challenge) with rhu-pGSN in a mouse model of pneumococcal pneumonia. rhu-pGSN without antibiotics increased survival and reduced morbidity and weight loss after infection with either penicillin-susceptible or penicillin-resistant pneumococci (serotypes 3 and 14, respectively). rhu-pGSN improves outcomes in a highly lethal pneumococcal pneumonia model when given after a clinically relevant delay, even in the setting of antimicrobial resistance.

Protective Effect Of Tiotropium Bromide On Airway Remodeling Of Chronic Asthma In Murine Model

2010 ◽  
Author(s):  
Ji Young Kang ◽  
Yong Hyun Kim ◽  
Seung Su Kim ◽  
Jin Woo Kim ◽  
Seok Chan Kim ◽  
...  
Keyword(s):  
Protective Effect ◽  
Murine Model ◽  
Airway Remodeling ◽  
Tiotropium Bromide ◽  
Chronic Asthma

scholarly journals Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hyojung Lee ◽  
Youngeun Kim ◽  
Hye Jin Kim ◽  
Soojin Park ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Murine Model ◽  
Lung Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Chronic Obstructive ◽  
Herbal Formula ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects

Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD. PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice. In addition, the TNF-αand IL-6 levels in BALF were decreased in the PM014 mice. Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation. These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.

The counter-balance of long-term expansion of memory and regulatory cells sustains chronic asthma in a murine model

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 108
Author(s):  
Milena F. Kabbara ◽  
Lidiane Z. Grund ◽  
Evilin N. Komegae ◽  
Douglas Boletini-Santos ◽  
Mônica Lopes-Ferreira ◽  
...  
Keyword(s):  
Murine Model ◽  
Chronic Asthma ◽  
Regulatory Cells

EFFICACY OF SULPHASALAZINE ON LUNG HISTOPATHOLOGY IN A MURINE MODEL OF CHRONIC ASTHMA

2008 ◽  
Vol 34 (8) ◽  
pp. 501-511 ◽  
Author(s):  
Duygu Olmez ◽  
Arzu Babayigit ◽  
Nevin Uzuner ◽  
Guven Erbil ◽  
Ozkan Karaman ◽  
...  
Keyword(s):  
Murine Model ◽  
Chronic Asthma ◽  
Lung Histopathology
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