AS-10: Admission Hyperglycemia Is an Independent Predictor for In-Hospital Death in Acute Myocardial Infarction in Both Diabetes Mellitus and Non–Diabetes Mellitus Patients

2010 ◽  
Vol 105 (9) ◽  
pp. 4A-5A
Author(s):  
Sang Yup Lim ◽  
Myung Ho Jeong ◽  
Young Jo Kim ◽  
Sung Chull Chae ◽  
Taek Jong Hong ◽  
...  
2012 ◽  
Vol 11 (1) ◽  
pp. 45-48 ◽  
Author(s):  
S. Yu. Martsevich ◽  
M. L. Ginsburg ◽  
N. P. Kutishenko ◽  
A. D. Deev ◽  
A. V. Fokina ◽  
...  

Aim. To identify the main anamnestic predictors of mortality in the acute phase of acute myocardial infarction (AMI). Material and methods. The study included all patients admitted to Lyubertsy District hospitals and diagnosed with AMI (n=1133). Results. Out of 1133 hospitalised patients, 172 died in the hospital; in-hospital lethality was 15,2%. Mean age of diseased patients was significantly higher than that in those survived. The risk of in-hospital death was significantly and independently associated with older age (relative risk 1,07). After adjustment for age and sex, other independent predictors of in-hospital AMI death included diabetes mellitus (DM), low physical activity, and selected psychosocial factors. Conclusion. The in-hospital lethality levels, observed in the LIS Study, were typical for the Russian Federation. The main anamnestic predictors of in-hospital death were low physical activity, DM, and psychosocial risk factors.


Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Kazuoki Dai ◽  
Masaharu Ishihara ◽  
Ichiro Inoue ◽  
Takuji Kawagoe ◽  
Yuji Shimatani ◽  
...  

Several studies have shown that both chronic kidney disease (CKD) and diabetes mellitus are risk factors for mortality in patients with acute myocardial infarction (AMI). This study was undertaken to investigate influence of CKD on the prognostic significance of diabetes in patients with AMI. Between January 1996 and December 2005, 888 patients with AMI underwent coronary angiography within 24 hours after the onset of chest pain. CKD was difined estimated glomerular filtration rate (eGFR) of less than 60.0 ml/minute/1.73 m 2 of body-surface area (stage3–5). Kaplan-Meier method was used to compare 5-year survival of diabetic and non-diabetic patients, in the presence (n=337) or absence (n=551). Kaplan-Meier curves for 5-year survival rate are shown in Figure . In the absence of CKD, there was no significant difference in 5-year survival rate between patients with diabetes and those without (93 % v.s. 94 %, p=0.82). In patients with CKD, however, diabetes was associated with lower 5-year survival rate (65 % v.s. 87 %, p<0.001). Multivariate analysis showed that diabetes was an independent predictor for 5-year survival in patients with CKD (OR 3.2, 95%CI 1.8–5.8, p=0.0002), but not in patients without CKD (OR 1.1, 95%CI 0.4–2.5, p=0.82). Diabetes mellitus was an independent predictor for death after AMI in patients with CKD. Aggressive treatment after AMI should be advocated in diabetic patients with CKD.


2000 ◽  
Vol 9 (3) ◽  
pp. 168-179 ◽  
Author(s):  
D Chyun ◽  
J Obata ◽  
J Kling ◽  
C Tocchi

OBJECTIVES: To examine in-hospital mortality after acute myocardial infarction in patients with diabetes mellitus. METHODS: All patients in an 800-bed teaching hospital who had a discharge diagnosis of myocardial infarction, verified by creatine kinase levels at admission, between 1991 and 1993 made up the study population. All 118 such patients who died during this period made up the case group. Two control subjects (n = 236), survivors of the hospitalization, matched by sex, age, and length of hospitalization, were selected randomly for each case. Information on the presence of diabetes mellitus, medical history, and data related to myocardial infarction were obtained through retrospective chart review. RESULTS: The mean age of all subjects in the study was 76 years. Thirty-three percent of the patients in the case group and 31% of the control subjects had a history of diabetes mellitus (odds ratio = 1.04; 95% CI, 0.64-1.70), indicating that diabetes mellitus was not associated with an increased risk of in-hospital death. The adjusted odds ratio was 1.10 (95% CI, 0.48-2.51) in patients with non-insulin-treated diabetes mellitus and 0.80 (95% CI, 0.34-1.86) in insulin-treated patients. Multivariate analysis, with conditional logistic regression, confirmed that known prognostic factors for myocardial infarction, rather than diabetic status, are predictive of in-hospital mortality. CONCLUSIONS: Once the effects of age are accounted for, the risk of in-hospital mortality is not greater in patients with diabetes mellitus than in patients without diabetes; however, diabetes mellitus may be an important factor for long-term survival.


Author(s):  
Ken Wei Tan ◽  
Joel R. Koo ◽  
Jue Tao Lim ◽  
Alex R. Cook ◽  
Borame L. Dickens

Chronic disease burdens continue to rise in highly dense urban environments where clustering of type II diabetes mellitus, acute myocardial infarction, stroke, or any combination of these three conditions is occurring. Many individuals suffering from these conditions will require longer-term care and access to clinics which specialize in managing their illness. With Singapore as a case study, we utilized census data in an agent-modeling approach at an individual level to estimate prevalence in 2020 and found high-risk clusters with >14,000 type II diabetes mellitus cases and 2000–2500 estimated stroke cases. For comorbidities, 10% of those with type II diabetes mellitus had a past acute myocardial infarction episode, while 6% had a past stroke. The western region of Singapore had the highest number of high-risk individuals at 173,000 with at least one chronic condition, followed by the east at 169,000 and the north with the least at 137,000. Such estimates can assist in healthcare resource planning, which requires these spatial distributions for evidence-based policymaking and to investigate why such heterogeneities exist. The methodologies presented can be utilized within any urban setting where census data exists.


2005 ◽  
Vol 96 (2) ◽  
pp. 183-186 ◽  
Author(s):  
Jie J. Cao ◽  
Michael Hudson ◽  
Michelle Jankowski ◽  
Fred Whitehouse ◽  
W. Douglas Weaver

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