Relation of Smoking Status to Serum Levels of N-Terminal Pro–Brain Natriuretic Peptide in Middle-Aged Men Without Overt Cardiovascular Disease

Background: Natriuretic peptides (NPs), including brain natriuretic peptide (BNP), are neurohormones involved in the regulation of water-sodium balance and the maintenance of cardiovascular homeostasis. A higher concentration of NPs is observed in females, but the mechanism behind this difference has not been fully elucidated. Methods: Randomly chosen 255 volunteers from the general population were examined. Overall, 196 people without severe cardiovascular disease were included (mean age 48 years, 35.7% male). A comprehensive assessment was performed, including anthropometric measurements, N-terminal pro-brain natriuretic peptide (NT-proBNP), total testosterone (TT) and sex hormone-binding globulin (SHBG) concentration, transthoracic echocardiography (ECHO), and body composition analysis by direct dual-energy X-ray absorptiometry (DEXA). The univariate analysis adjusted by the known affecting factors determined which measurements were independently associated with NT-proBNP concentration. Results: NT-proBNP concentration was positively associated with gynoid fat mass, gynoid/total fat (G/TF) mass index, SHBG and negatively with android/gynoid (A/G) fat mass index, TT and calculated free testosterone (CFT) concentrations. Furthermore, body composition parameters remained independently associated with NT-proBNP levels even after adjusting for CFT and SHBG. Conclusion: In the population without severe cardiovascular disease, the NT-proBNP concentration is independently associated with lower availability of testosterone and higher gynoid fat distribution, which may explain higher NPs levels in females.

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Diagnosing cardiovascular disease in western lowland gorillas (Gorilla gorilla gorilla) with brain natriuretic peptide

PLoS ONE ◽

10.1371/journal.pone.0214101 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0214101 ◽

Cited By ~ 4

Author(s):

Suzan Murray ◽

Jennifer C. Kishbaugh ◽

Lee-Ann C. Hayek ◽

Ilana Kutinsky ◽

Patricia M. Dennis ◽

...

Keyword(s):

Cardiovascular Disease ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Gorilla Gorilla ◽

Gorilla Gorilla Gorilla ◽

Western Lowland Gorillas ◽

Lowland Gorillas

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Elevated Pro-Brain Natriuretic Peptide, Troponin T and Malnutrition Inflammatory Score in Chronic Hemodialysis Patients with Overt Cardiovascular Disease

Nephron Clinical Practice ◽

10.1159/000320195 ◽

2011 ◽

Vol 117 (3) ◽

pp. c198-c205 ◽

Cited By ~ 7

Author(s):

Hernán Trimarchi ◽

Alexis Muryan ◽

Vicente Campolo-Girard ◽

Mariana Dicugno ◽

Nanci Barucca ◽

...

Keyword(s):

Cardiovascular Disease ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Troponin T ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

Inflammatory Score

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Prognostic Value of Preoperative Brain Natriuretic Peptide Serum Levels in Liver Transplantation

Transplantation Journal ◽

10.1097/tp.0000000000001077 ◽

2016 ◽

Vol 100 (4) ◽

pp. 819-824 ◽

Cited By ~ 8

Author(s):

Amelie Toussaint ◽

Emmanuel Weiss ◽

Linda Khoy-Ear ◽

Sylvie Janny ◽

Jacqueline Cohen ◽

...

Keyword(s):

Liver Transplantation ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Prognostic Value ◽

Serum Levels

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Performance indicators of left ventricular strain, wall stress and serum brain natriuretic peptide levels in chronic hemodialysis patients

Azerbaijan Journal of Cardiovascular Surgery ◽

10.30546/azjcvs.2021.2.1.22 ◽

2021 ◽

pp. 22-39

Author(s):

Abeer M. SHAWKY ◽

Rehab M. HAMDY ◽

Asmaa A. ELMADBOULY

Keyword(s):

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Systolic Function ◽

Global Longitudinal Strain ◽

Wall Stress ◽

Serum Levels ◽

Left Ventricular ◽

Chronic Hemodialysis ◽

Lv Function ◽

Endstage Renal Disease

Background: Left ventricular (LV) global longitudinal strain (GLS) is a reliable determinant of LV systolic function. The precise relationship between LV wall stress and serum brain natriuretic peptide (BNP) concentrations in hemodialysis (HD) patients require clariϐication. BNP levels are raised in patients with endstage renal disease (ESRD) and could reflect LV impairment amongst HD patients. Objective: This study sought to evaluate the clinical utility of LV–GLS, wall stress and serum BNP levels in chronic HD patients. The correlations between BNP levels with both LV wall stress and LV–GLS were assessed. Methodology: A total of 30 ESRD patients on regular HD – divided into 15 patients with LV ejection fraction (EF) <50% and 15 patients with LV EF > 50% – and 15 agematched healthy subjects were assessed. LV function and structure were measured using conventional echocardiography, including LV meridional wall stress (LVMWS), LV mass index (LVM I) and two-dimensional speckle tracking echocardiography for determination of LV–GLS. Serum BNP levels were evaluated after HD sessions. Results: There were significant increases in LVM SW (189.2 ± 81 vs. 72.2 ± 20.6 dynes/cm 2 2 1000, P < 0.0001), higher levels of BNP (1238 ± 1085.5 vs. 71 ± 23.4 pg/ml, P<0.0001), w hilst LV–GLS was signiϐicantly reduced (15.1 ± 3.1 vs. 20.8 ± 1.7%, P <0.0001) in HD patients, when compared to the controls. Higher values of LVMWS (246.9 ± 67.5 vs. 131.5 ± 43.6 dynes/cm 2 2 1000, P <0.0001) and BNP (1925.4 ± 1087 vs. 550.5 ± 496.5pg/ml, P < 0.0005) with further impairment of LV–GLS (13.8 ± 2.5 vs. 16.4 ± 5.4%, P < 0.05) were found in patients with LV EF 0 50% than those with LV EF > 50%. Serum levels of BNP were positively correlated with LVM I (r = 0.896, P < 0.0001) and LVMW S (r = 0.697, P < 0.0001), but negatively correlated with LV–GLS (r = 0 0.587, P < 0.0001). Conclusion: LV–GLS and LVMWS are useful imaging markers for detection of LV dysfunction in HD patients. Serum BNP level is influenced by LV structural abnormalities, being regarded as a crucial hemodynamic biomarker in those patients.

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