Left Ventricular Reverse Remodeling in Long-Term (>12 Years) Survivors With Idiopathic Dilated Cardiomyopathy

2013 ◽  
Vol 111 (1) ◽  
pp. 106-110 ◽  
Author(s):  
Yoshihisa Matsumura ◽  
Eri Hoshikawa-Nagai ◽  
Toru Kubo ◽  
Naohito Yamasaki ◽  
Takashi Furuno ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Reverse Remodeling ◽  
Left Ventricular Reverse Remodeling

Abstract 17315: Low Occurrence of Left Ventricular Reverse Remodeling and Poor Long-term Prognosis in Dilated Cardiomyopathy with Higher Immunohistological Expression of Myocardial Tenascin-C

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Tetsuro Yokokawa ◽  
Yasuo Sugano ◽  
Takafumi Nakayama ◽  
Masao Takigami ◽  
Toshiyuki Nagai ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Matrix Protein ◽  
Left Ventricular ◽  
Extracellular Matrix Protein ◽  
Reverse Remodeling ◽  
Tenascin C ◽  
Left Ventricular Reverse Remodeling ◽  
Lv Remodeling ◽  
Long Term Prognosis

Background: Tenascin-C (TN-C) is an extracellular matrix protein, and may regulate matrix organization during tissue remodeling. Although serum TN-C is reported as a prognostic biomarker in patients with dilated cardiomyopathy (DCM), the clinical significance of myocardial expression of TN-C remains undetermined. The objective of this study is to clarify the significance of myocardial TN-C expression on left ventricular (LV) remodeling and long-term prognosis in patients with DCM. Methods: Eighty consecutive patients in 2005 and 2006, who were diagnosed with DCM by excluding ischemic cardiomyopathy and secondary cardiomyopathy by coronary angiography and right ventricular endomyocardial biopsy, were analyzed. Those patients were followed up to 73±34 months, and their clinical data were obtained. Immunohistochemistry for TN-C was performed on stored biopsy specimens to examine the association of TN-C deposition with the occurrence of LV reverse remodeling as well as long-term mortality. Immunostained area of myocardial TN-C was measured densitometrically and calculated in percent by the fraction of TN-C stained area to the whole myocardium (TN-C area). LV reverse remodeling was defined as LV end-diastolic dimension ≤55 mm and fractional shortening ≥25% by 60 months after diagnosis. Results: TN-C area was 1.2±1.6% on average. Twenty-two patients (28%) underwent LV reverse remodeling. Patients with LV reverse remodeling showed less TN-C area at diagnosis than those without (TN-C area; 0.6±0.5 vs. 1.5±1.8%, p=0.021). Patients were divided into two groups according to the extent of TN-C area; high TN-C group (TN-C area≥1.5%, n=19) and low TN-C group (TN-C area<1.5%, n=61). LV reverse remodeling occurred less frequently in high TN-C group compared with low TN-C group (5% vs 33%, p=0.01). Eleven patients (14%) died during the observation period. Kaplan-Meier analysis revealed high TN-C group had worse prognosis than low TN-C group (p=0.009). Conclusions: Patients with higher immunohistological expression of myocardial TN-C in DCM were characterized with lower occurrence of later LV reverse remodeling and poorer long-term prognosis. Myocardial TN-C may have some crucial role in LV remodeling process in patients with DCM.

Incidence and prognosis implications of long term left ventricular reverse remodeling in patients with dilated cardiomyopathy

2016 ◽  
Vol 203 ◽  
pp. 1114-1121 ◽  
Author(s):  
Isabel Ruiz-Zamora ◽  
Jorge Rodriguez-Capitan ◽  
Alicia Guerrero-Molina ◽  
Luis Morcillo-Hidalgo ◽  
Isabel Rodriguez-Bailon ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Left Ventricular ◽  
Reverse Remodeling ◽  
Left Ventricular Reverse Remodeling

Left Ventricular Reverse Remodeling After Beta-blocker Therapy in Dilated Cardiomyopathy: Is it Maintained at Long-term Follow-up?

2009 ◽  
Vol 15 (7) ◽  
pp. S153
Author(s):  
Yuichi Baba ◽  
Yoshihisa Matsumura ◽  
Toru Kubo ◽  
Eri Hoshikawa ◽  
Makoto Okawa ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Beta Blocker ◽  
Left Ventricular ◽  
Reverse Remodeling ◽  
Blocker Therapy ◽  
Beta Blocker Therapy ◽  
Left Ventricular Reverse Remodeling ◽  
Long Term Follow Up

scholarly journals Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling

2020 ◽  
Vol 9 (8) ◽  
pp. 2426 ◽  
Author(s):  
Antonio Cannata ◽  
Paolo Manca ◽  
Vincenzo Nuzzi ◽  
Caterina Gregorio ◽  
Jessica Artico ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Reverse Remodeling ◽  
Ventricular Assist ◽  
Ventricular Ejection Fraction ◽  
Left Ventricular Reverse Remodeling ◽  
Significant Difference

Background. Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown. Aim. We investigated the relationship between LVRR and sex and its long-term outcomes. Methods. A cohort of 605 DCM patients with available follow-up data was consecutively enrolled. LVRR was defined, at 24-month follow-up evaluation, as an increase in left ventricular ejection fraction (LVEF) ≥ 10% or a LVEF > 50% and a decrease ≥ 10% in indexed left ventricular end-diastolic diameter (LVEDDi) or an LVEDDi ≤ 33 mm/m2. Outcome measures were a composite of all-cause mortality/heart transplantation (HTx) or ventricular assist device (VAD) and a composite of Sudden Cardiac Death (SCD) or Major Ventricular Arrhythmias (MVA). Results. 181 patients (30%) experienced LVRR. The cumulative incidence of LVRR at 24-months evaluation was comparable between sexes (33% vs. 29%; p = 0.26). During a median follow-up of 149 months, women experiencing LVRR had the lowest rate of main outcome measure (global p = 0.03) with a 71% relative risk reduction compared to men with LVRR, without significant difference between women without LVRR and males. A trend towards the same results was found regarding SCD/MVA (global p = 0.06). Applying a multi-state model, male sex emerged as an independent adverse prognostic factor even after LVRR completion. Conclusions. Although the rate of LVRR was comparable between sexes, females experiencing LVRR showed the best outcomes in the long term follow up compared to males and females without LVRR. Further studies are advocated to explain this difference in outcomes between sexes.

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