The effect of protein supplements on weight loss, body composition, protein status, and micronutrients post laparoscopic sleeve gastrectomy (LSG): A Randomised Controlled Trial (RCT)

Weight loss is key to controlling the increasing prevalence of metabolic syndrome (MS) and its components, i.e., central obesity, hypertension, prediabetes and dyslipidaemia. The goals of our study were two-fold. First, we characterised the relationships between eating duration, unprocessed and processed food consumption and metabolic health. During 4 weeks of observation, 213 adults used a smartphone application to record food and drink consumption, which was annotated for food processing levels following the NOVA classification. Low consumption of unprocessed food and low physical activity showed significant associations with multiple MS components. Second, in a pragmatic randomised controlled trial, we compared the metabolic benefits of 12 h time-restricted eating (TRE) to standard dietary advice (SDA) in 54 adults with an eating duration > 14 h and at least one MS component. After 6 months, those randomised to TRE lost 1.6% of initial body weight (SD 2.9, p = 0.01), compared to the absence of weight loss with SDA (−1.1%, SD 3.5, p = 0.19). There was no significant difference in weight loss between TRE and SDA (between-group difference −0.88%, 95% confidence interval −3.1 to 1.3, p = 0.43). Our results show the potential of smartphone records to predict metabolic health and highlight that further research is needed to improve individual responses to TRE such as a shorter eating window or its actual clock time.

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Efficacy of a Multi-Component m-Health Diet, Physical Activity, and Sleep Intervention on Dietary Intake in Adults with Overweight and Obesity: A Randomised Controlled Trial

Nutrients ◽

10.3390/nu13072468 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2468

Author(s):

Sasha Fenton ◽

Tracy L. Burrows ◽

Clare E. Collins ◽

Anna T. Rayward ◽

Beatrice Murawski ◽

...

Keyword(s):

Physical Activity ◽

Weight Loss ◽

Randomised Controlled Trial ◽

Dietary Intake ◽

Controlled Trial ◽

Intervention Group ◽

Weight Loss Intervention ◽

Traditional Group ◽

Traditional Diet ◽

Randomised Controlled

This three-arm randomised controlled trial evaluated whether (1) a multi-component weight loss intervention targeting diet, physical activity (PA), and sleep was effective at improving dietary intake over six months and 12 months, compared with a control, and (2) the enhanced diet, PA, and sleep intervention was more effective at improving dietary intake than the traditional diet and PA intervention. A total of 116 adults (70% female, 44.5 years, BMI 31.7 kg/m2) were randomised to either traditional diet and PA intervention; enhanced diet, PA, and sleep intervention; or wait-list control. To examine between-group differences, intervention groups were pooled and compared with the control. Then, the two intervention groups were compared. At six months, the pooled intervention group consumed 1011 fewer kilojoules/day (95% CI −1922, −101), less sodium (−313.2 mg/day; 95% CI −591.3, −35.0), and higher %EI from fruit (+2.1%EI; 95% CI 0.1, 4.1) than the controls. There were no differences in intake between the enhanced and traditional groups at six months. At 12 months, the pooled intervention and control groups reported no significant differences. However, compared to the traditional group, the enhanced reported higher %EI from nutrient-dense foods (+7.4%EI; 95% CI 1.3, 13.5) and protein (+2.4%EI; 95% CI 0.1, 4.6), and reduced %EI from fried/takeaway foods (−3.6%EI; 95% CI −6.5, −0.7), baked sweet products (−2.0%EI; 95% CI −3.6, −0.4), and packaged snacks (−1.1%EI; 95% CI −2.2, −0.3). This weight loss intervention reduced total energy and sodium intakes as well as increased fruit intake in adults at six months. The enhanced intervention group reported improved dietary intake relative to the traditional group at 12 months.

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Erectile function improves in obese men following weight loss during the SHED-IT randomised controlled trial

Obesity Research & Clinical Practice ◽

10.1016/j.orcp.2013.12.632 ◽

2013 ◽

Vol 7 ◽

pp. e71

Author(s):

Clare E. Collins ◽

Megan Jensen ◽

Myles D. Young ◽

Robin Callister ◽

Ron C. Plotnikoff ◽

...

Keyword(s):

Weight Loss ◽

Randomised Controlled Trial ◽

Erectile Function ◽

Controlled Trial ◽

Randomised Controlled

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Text messaging (SMS) as a tool to facilitate weight loss and prevent metabolic deterioration in clinically healthy overweight and obese subjects: a randomised controlled trial

Scandinavian Journal of Primary Health Care ◽

10.1080/02813432.2017.1358435 ◽

2017 ◽

Vol 35 (3) ◽

pp. 262-270 ◽

Cited By ~ 7

Author(s):

Vija Silina ◽

Mesfin K. Tessma ◽

Silva Senkane ◽

Gita Krievina ◽

Guntis Bahs

Keyword(s):

Weight Loss ◽

Randomised Controlled Trial ◽

Text Messaging ◽

Controlled Trial ◽

Obese Subjects ◽

Randomised Controlled

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Effectiveness and cost of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in obesity services (STRIVE study): study protocol of an open-label, real-world, randomised, controlled trial

BMJ Open ◽

10.1136/bmjopen-2019-034137 ◽

2020 ◽

Vol 10 (2) ◽

pp. e034137 ◽

Cited By ~ 1

Author(s):

Dimitris Papamargaritis ◽

Werd Al-Najim ◽

Jonathan Lim ◽

James Crane ◽

Mike Lean ◽

...

Keyword(s):

Weight Loss ◽

Randomised Controlled Trial ◽

Research Ethics ◽

Real World ◽

Regulatory Authority ◽

Controlled Trial ◽

Ethics Committee ◽

Stopping Rules ◽

Open Label ◽

Randomised Controlled

IntroductionIn the UK and Ireland, severe and complex obesity is managed in specialist weight management services (SWMS), which provide multicomponent lifestyle interventions to support weight loss, and use of medication if available. Liraglutide 3 mg (LIRA 3 mg) is an effective weight-loss medication, but weight loss in individual patients is variable, and its efficacy has not been assessed in SWMS. This study aims to investigate whether a targeted prescribing pathway for LIRA 3 mg with multiple prespecified stopping rules could help people with severe obesity and established complications achieve ≥15% weight loss in order to determine whether this could be considered a clinically effective and cost-effective strategy for managing severe and complex obesity in SWMS.Methods and analysisIn this 2-year, multicentre, open-label, real-world randomised controlled trial, 384 adults with severe and complex obesity (defined as body mass index ≥35 kg/m2plus either prediabetes, type 2 diabetes, hypertension or sleep apnoea) will be randomised via a 2:1 ratio to receive either standard SWMS care (n=128) or standard SWMS care plus a targeted prescribing pathway for LIRA 3 mg with prespecified stopping rules at 16, 32 and 52 weeks (n=256).The primary outcome is to compare the proportion of participants achieving a weight loss of ≥15% at 52 weeks with a targeted prescribing pathway versus standard care. Secondary outcomes include a comparison of (1) the weight loss maintenance at 104 weeks and (2) the budget impact and cost effectiveness between the two groups in a real-world setting.Ethics and disseminationThe Health Research Authority and the Medicines and Healthcare products Regulatory Authority in UK, the Health Products Regulatory Authority in Ireland, the North West Deanery Research Ethics Committee (UK) and the St Vincent’s University Hospital European Research Ethics Committee (Ireland) have approved the study. The findings of the study will be published in peer-reviewed journals.Trial registration numberClinicalTrials.gov—Identifier:NCT03036800.European Clinical Trials Database—Identifier: EudraCT Number 2017-002998-20.

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Evaluation of the impact of an internet-based weight loss program for men: The SHED-IT randomised controlled trial

Journal of Science and Medicine in Sport ◽

10.1016/j.jsams.2008.12.040 ◽

2009 ◽

Vol 12 ◽

pp. S15

Author(s):

P. Morgan ◽

D. Lubans ◽

R. Callister ◽

J. Warren ◽

C. Collins

Keyword(s):

Weight Loss ◽

Randomised Controlled Trial ◽

Controlled Trial ◽

Weight Loss Program ◽

Randomised Controlled ◽

The Impact

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Evaluating differences in the clinical impact of a free online weight loss programme, a resource-intensive commercial weight loss programme and an active control condition: a parallel randomised controlled trial

BMC Public Health ◽

10.1186/s12889-019-8061-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Aidan Q. Innes ◽

Greig Thomson ◽

Mary Cotter ◽

James A. King ◽

Niels B. J. Vollaard ◽

...

Keyword(s):

Weight Loss ◽

Randomised Controlled Trial ◽

Active Control ◽

Body Mass ◽

Controlled Trial ◽

Free Access ◽

Healthy Weight ◽

Supervised Exercise ◽

Weight Loss Programme ◽

Randomised Controlled

Abstract Background Finding effective intervention strategies to combat rising obesity levels could significantly reduce the burden that obesity and associated non-communicable diseases places on both individuals and the National Health Service. Methods In this parallel randomised-controlled trial, 76 participants who are overweight or obese (50 female) were given free access to a fitness centre for the duration of the 12-week intervention and randomised to one of three interventions. The commercial intervention, the Healthy Weight Programme, (HWP, n = 25, 10/15 men/women) consisted of twelve 1-h nutrition coaching sessions with a nutritionist delivered as a mixture of group and 1 to 1 sessions. In addition, twice-weekly exercise sessions (24 in total) were delivered by personal trainers for 12 weeks. The NHS intervention (n = 25, 8/17 men/women) consisted of following an entirely self-managed 12-week online NHS resource. The GYM intervention (n = 26, 8/18 men/women) received no guidance or formal intervention. All participants were provided with a gym induction for safety and both the NHS and GYM participants were familiarised with ACSM physical activity guidelines by way of a hand-out. Results The overall follow-up rate was 83%. Body mass was significantly reduced at post-intervention in all groups (HWP: N = 18, − 5.17 ± 4.22 kg, NHS: N = 21–4.19 ± 5.49 kg; GYM: N = 24–1.17 ± 3.00 kg; p < 0.001) with greater reductions observed in HWP and NHS groups compared to GYM (p < 0.05). Out with body mass and BMI, there were no additional statistically significant time x intervention interaction effects. Conclusions This is the first study to evaluate the efficacy of both a free online NHS self-help weight-loss tool and a commercial weight loss programme that provides face-to-face nutritional support and supervised exercise. The findings suggest that both interventions are superior to an active control condition with regard to eliciting short-term weight-loss. Trial registration ISRCTN Registry - ISRCTN31489026. Prospectively registered: 27/07/16.

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