Allergic rhinitis and serum 25-hydroxyvitamin D level in Korean adults

The association between vitamin D status and lung function in adults with asthma remains unclear.We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19–55 years) with self-reported asthma in the Nord-Trøndelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol·L−1was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (β) and 95% confidence intervals.44% of asthma adults had serum 25(OH)D levels <50 nmol·L−1. Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol·L−1was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol·L−1was significantly associated with lower FEV1/FVC ratio (β=−8.60%; 95% CI: −16.95%– −0.25%).Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.

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Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis

Asia Pacific Allergy ◽

10.5415/apallergy.2017.7.4.213 ◽

2017 ◽

Vol 7 (4) ◽

pp. 213 ◽

Cited By ~ 2

Author(s):

Hai-Yan Wu ◽

Jin-Xiang Chen ◽

Hui-Qin Tian ◽

Xiu-Ling Zhang ◽

Hai-Yan Bian ◽

...

Keyword(s):

Allergic Rhinitis ◽

Hydroxyvitamin D ◽

Persistent Allergic Rhinitis ◽

25 Hydroxyvitamin D ◽

Blood Eosinophils

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Association of Serum 25-Hydroxyvitamin D and Parathyroid Hormone With Hypertension in Middle-Aged and Older Korean Adults

American Journal of Hypertension ◽

10.1093/ajh/hpv059 ◽

2015 ◽

Vol 29 (1) ◽

pp. 96-103 ◽

Cited By ~ 4

Author(s):

Dasom Kim ◽

Jihye Kim

Keyword(s):

Parathyroid Hormone ◽

Middle Aged ◽

Hydroxyvitamin D ◽

Korean Adults ◽

25 Hydroxyvitamin D

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Correlation Between Serum 25-Hydroxyvitamin D Levels and Allergic Rhinitis in Children and Adolescents in Korea

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2014.12.1823 ◽

2015 ◽

Vol 135 (2) ◽

pp. AB270 ◽

Cited By ~ 2

Author(s):

Seo Hee Yoon ◽

Yoon Hee Kim ◽

Young A. Park ◽

In Suk Sol ◽

Min Jung Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Children And Adolescents ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

Mediators of Inflammation ◽

10.1155/2014/520241 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 28

Author(s):

Anna Bonanno ◽

Sebastiano Gangemi ◽

Stefania La Grutta ◽

Velia Malizia ◽

Loredana Riccobono ◽

...

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Allergic Asthma ◽

Allergic Disease ◽

Plasma Levels ◽

Disease Duration ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Levels ◽

Blood Eosinophils

Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR. In conclusion, low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity.

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