scholarly journals 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Anna Bonanno ◽  
Sebastiano Gangemi ◽  
Stefania La Grutta ◽  
Velia Malizia ◽  
Loredana Riccobono ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Allergic Asthma ◽  
Allergic Disease ◽  
Plasma Levels ◽  
Disease Duration ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Low Levels ◽  
Blood Eosinophils

Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR. In conclusion, low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity.

scholarly journals Vitamin D and Risk for Vitamin A Intoxication in an 18-Month-Old Boy

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Valentina Talarico ◽  
Massimo Barreca ◽  
Rossella Galiano ◽  
Maria Concetta Galati ◽  
Giuseppe Raiola
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
High Serum ◽  
Renal Ultrasound ◽  
Once Daily ◽  
Hydroxyvitamin D ◽  
Vitamin D Intoxication ◽  
Intravenous Hydration ◽  
25 Hydroxyvitamin D ◽  
Low Levels

An 18-month-old boy presented with abdominal pain, vomiting, diarrhea, and poor appetite for 6 days. He had been given a multivitamin preparation once daily, containing 50.000 IU of vitamin D and 10.000 IU of vitamin A for a wide anterior fontanelle for about three months. He presented with hypercalcemia, low levels of parathyroid hormone (PTH), and very high serum 25-hydroxyvitamin D (25-OHD) levels. Renal ultrasound showed nephrocalcinosis. He did not have sign or symptom of vitamin A intoxication. Patient was successfully treated with intravenous hydration, furosemide, and prednisolone. With treatment, serum calcium returned rapidly to the normal range and serum 25-OHD levels were reduced progressively. In conclusion the diagnosis of vitamin D deficiency rickets without checking 25-OHD levels may cause redundant treatment that leads to vitamin D intoxication (VDI).

scholarly journals Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis

2017 ◽  
Vol 7 (4) ◽  
pp. 213 ◽  
Author(s):  
Hai-Yan Wu ◽  
Jin-Xiang Chen ◽  
Hui-Qin Tian ◽  
Xiu-Ling Zhang ◽  
Hai-Yan Bian ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Hydroxyvitamin D ◽  
Persistent Allergic Rhinitis ◽  
25 Hydroxyvitamin D ◽  
Blood Eosinophils

scholarly journals Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case—control study and randomised clinical trial

2012 ◽  
Vol 201 (5) ◽  
pp. 360-368 ◽  
Author(s):  
Marie Kjærgaard ◽  
Knut Waterloo ◽  
Catharina E. A. Wang ◽  
Bjørg Almås ◽  
Yngve Figenschau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Rating Scale ◽  
Seasonal Pattern ◽  
Depression Scale ◽  
High Serum ◽  
High Dose ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Low Levels

AimsTo compare depressive symptoms in participants with low and high serum 25-hydroxyvitamin D (25(OH)D) levels and to examine whether supplementation with vitamin D3 would improve symptoms in those with low serum 25(OH)D levels.MethodParticipants with low 25(OH)D levels were randomised to either placebo or 40 000 IU vitamin D3 per week for 6 months. Individuals with high serum 25(OH)D levels were used as nested controls. Depressive symptoms were evaluated with the Beck Depression Inventory, Hospital Anxiety and Depression Scale, Seasonal Pattern Assessment Scale and Montgomery-Åsberg Depression Rating Scale. The study was registered at ClinicalTrials.gov (NCT00960232).ResultsParticipants with low 25(OH)D levels (n=230) at baseline were more depressed (P<0.05) than participants with high 25(OH)D levels (n=114). In the intervention study no significant effect of high-dose vitamin D was found on depressive symptom scores when compared with placebo.ConclusionsLow levels of serum 25(OH)D are associated with depressive symptoms, but no effect was found with vitamin D supplementation.

scholarly journals The Relationship of 25-Hydroxyvitamin D Plasma Levels with Breast Cancer Stadium Assessed from Menopause Status

2021 ◽  
Vol 3 (1) ◽  
pp. 65-72
Author(s):  
Ika Waraztuty ◽  
Astrid Siska Pratiwi ◽  
Melya Susanti ◽  
Ira Astuti ◽  
Zakirullah
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Plasma Levels ◽  
Menopausal Status ◽  
Observational Research ◽  
Cancer Stage ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Post Menopausal ◽  
The Relationship

Breast cancer is a type of cancer with high incidence and mortality especially in developing countries. Vitamin D regulates the expression a number of genes involved in the development of cancer cells. The aim of this study is to analyze the relationship between 25-hydroxyvitamin D (25 (OH) D) plasma level with breast cancer stage based on menopausal status. This is an observational research method with cross sectional design. Research subjects were 53 newly diagnosed breast cancer patients and had not received chemotherapy. Menopausal status and stage data were obtained from interviews and medical record data. Levels of 25-hydroxyvitamin D plasma were measured (ELISA) method. The results obtained Stage II, III and IV each have an average level of vitamin D of 28,56 ng/ml (95% CI; 23,61 – 33,52 ng/ml),  28,18 ng/ml (95% CI: 24,49 – 31,87 ng/ml) and  27,86 ng/ml  (95% CI: 22,68 – 33,04 ng/ml).The average plasma concentration of 25 (OH) D in pre-menopausal patients is 28,54 ng/ml and average plasma 25 (OH) D levels in post-menopausal patients is 27,79 ng/ml. There was no significant relationship between plasma levels of 25 (OH) D and breast cancer stage in both pre-menopausal and post-menopausal patients.

Plasma levels of vitamin D and some metabolites in marine mammals

1988 ◽  
Vol 66 (6) ◽  
pp. 1297-1300 ◽  
Author(s):  
K. M. Keiver ◽  
K. Ronald ◽  
H. H. Draper
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Marine Mammals ◽  
Plasma Calcium ◽  
Cetacean Species ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Very High

Levels of vitamin D, 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and calcium were determined in the plasma of various captive and wild pinniped and cetacean species. Vitamin D (< 0.4–5 ng∙mL−1) and 25-hydroxyvitamin D (4–84 ng∙mL−1) levels in the pinniped plasma were similar to those found in nonmarine mammals. 24,25-Dihydroxyvitamin D levels in seals (3–48 ng∙mL−1) were high compared with those of other mammals, and the ratios of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D in fasting pups were extremely high. The belugas and bottlenosed dolphins had very high levels of both 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D compared with the pinnipeds and other mammals, but plasma calcium levels were normal for these species of cetaceans.

scholarly journals The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis

2019 ◽  
pp. 014556131987431 ◽  
Author(s):  
Kübra Çoban ◽  
Işılay Öz ◽  
Deniz İlhan Topçu ◽  
Erdinç Aydın
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Serum Levels ◽  
Control Group ◽  
Study Group ◽  
Hydroxyvitamin D ◽  
Median Serum ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Skin Prick Tests

We aimed to clarify the relation between allergic rhinitis and the serum levels of 25-hydroxivitamin D in the adult population. The study group consisted of 86 patients with allergic rhinitis who were diagnosed with the help of history of allergy, positive signs for allergy, blood samples, and positive skin prick tests; while the control group included 43 age- and sex-matched healthy volunteers with negative skin prick tests. The demographic data, medical history, findings in the physical examinations, serum levels of total immunoglobulin E (IgE) and 25-hydroxyvitamin D, and skin prick test results of the groups were noted. A total of 129 patients fulfilling the necessary criteria were enrolled. The median serum 25-hydroxyvitamin D levels in the study group were significantly lower compared to the control group ( P = .014). In the study group, median serum vitamin D levels were significantly higher in men, compared to women ( P = .03). There was a significant negative correlation between IgE and vitamin D levels in the allergic rhinitis group ( P = .028, r = −0.246). This study showed that patients with allergic rhinitis might be more vulnerable to have lower serum levels of vitamin D. Thus, vitamin D supplementation as an adjunctive therapy may be considered in those patients.

scholarly journals The Role of Vitamin D in Respiratory Allergies Prevention. Why the Effect Is so Difficult to Disentangle?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1801 ◽  
Author(s):  
Hanna Sikorska-Szaflik ◽  
Barbara Sozańska
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Allergic Diseases ◽  
Childhood Diseases ◽  
Systematic Analysis ◽  
Hydroxyvitamin D ◽  
Respiratory Allergies ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Asthma and allergic rhinitis are the most common chronic childhood diseases with an increasing prevalence worldwide. There is an urgent need to look for methods of preventing allergic diseases from an early age. The relationship between vitamin D status and allergic diseases has been discussed in several studies recently. 25-hydroxyvitamin D (25(OH)D) is suggested to affect the development and/or severity of asthma and allergic rhinitis. Observational studies have seemed to confirm that vitamin D deficiency may contribute to an increase in allergy and asthma. Following interventional studies, however, have yielded ambiguous results. In this review, we describe recent findings regarding 25(OH)D impact on allergic diseases and provide a systematic analysis of the causes of great variability of the achieved results in different studies.

What diseases are causally linked to vitamin D deficiency?

2015 ◽  
Vol 101 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Ian R Reid
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Indian Subcontinent ◽  
Clinical Consequence ◽  
Hydroxyvitamin D ◽  
Wide Range ◽  
25 Hydroxyvitamin D ◽  
Low Levels ◽  
Meta Analyses ◽  
Trial Evidence

The classical clinical consequence of vitamin D deficiency is osteomalacia, presenting as rickets in children. This remains a common problem in parts of the Middle East and the Indian subcontinent, and occurs when serum 25-hydroxyvitamin D levels are <25 nmol/L. Osteomalacia remains the only problem that is unequivocally a consequence of vitamin D deficiency. Low levels of 25-hydroxyvitamin D are observed in a wide range of conditions, but consistent trial evidence of amelioration of these conditions with vitamin D is lacking. Monotherapy with vitamin D has not been found to be effective in meta-analyses of trials assessing its effects on bone density, fractures or falls. At present, supplements should be advised for individuals at risk of having serum 25-hydroxyvitamin D levels in the 25–40 nmol/L range, or below, with a view to prevention of osteomalacia.

EFFECT OF A SINGLE INTRAMUSCULAR DOSE OF VITAMIN D ON CONCENTRATIONS OF LIPOSOLUBLE VITAMINS IN THE PLASMA OF HEIFERS WINTER-FED OAT SILAGE, GRASS SILAGE OR HAY

1980 ◽  
Vol 60 (2) ◽  
pp. 311-318 ◽  
Author(s):  
M. HIDIROGLOU ◽  
M. IVAN ◽  
J. G. PROULX ◽  
J. R. LESSARD
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Dietary Treatment ◽  
Hydroxyvitamin D ◽  
Intramuscular Dose ◽  
Grass Silage ◽  
Weight Gains ◽  
Calcium Phosphorus ◽  
25 Hydroxyvitamin D ◽  
Blood Profiles

Blood profiles for 25 hydroxyvitamin D (250HD), vitamins A and E, calcium, phosphorus and magnesium in three groups of Shorthorn heifers winter-fed either oat silage, grass silage or hay have been established. In each dietary treatment, half of the animals were injected with a single intramuscular dose of vitamin D3 (1 000 000 IU). The injections increased plasma 250HD levels (ng/mL) at the end of the experiment from 35 to 44 for oat silage, from 35 to 75 for grass silage and from 29 to 40 for hay. The plasma 250HD in the oat silage-fed heifers approached levels that were suggestive of vitamin D deficiency. 250HD plasma levels of cattle on grass silage were more responsive to the vitamin D treatment than those on oat silage or hay. Plasma levels of vitamin A at the end of the experiment (134 day s) were significantly higher (P < 0.01) in the silage-fed animals than in the hay-fed animals. The vitamin D-treated heifers fed oat silage had higher (P < 0.05) blood vitamin E levels than the other heifers. Plasma calcium, phosphorus and magnesium levels appeared to be unaffected by diet or vitamin D treatment. Greater weight gains were observed in heifers on hay than in those on grass silage or oat silage. Weight gains tended to be higher (NS) in the vitamin D-treated heifers fed oat silage than in those that were not treated. Gains were also higher (P < 0.05) with the hay than with the silage diets.

A Comparison of Vitamin D Levels in Nondiabetic and Diabetic Patient Populations

2009 ◽  
Vol 99 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Robert M. Yoho ◽  
Jill Frerichs ◽  
Nicholas B. Dodson ◽  
Robert Greenhagen ◽  
Simon Geletta
Keyword(s):  
Vitamin D ◽  
Diabetic Patient ◽  
Diabetic Patients ◽  
Group 13 ◽  
Charcot Neuroarthropathy ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Low Levels ◽  
Foot Disease

Background: This study was designed to compare the vitamin D levels in a cohort of nondiabetic patients to populations of diabetic patients with and without Charcot neuroarthropathy. Methods: A total of 41 participants (22 male, 19 female) with a mean ± SD age of 59 ± 9.43 years had serum 25-hydroxyvitamin D levels tested. Fifteen participants composed the nondiabetic group; 13, the group with diabetes but without Charcot neuroarthropathy; and 13, the group with both diabetes and Charcot neuroarthropathy. Results: The results of the study showed that the vitamin D levels in both diabetic populations were significantly lower (P &lt; .05) than the nondiabetic population. There was no statistical difference between the group with diabetes but without Charcot foot disease and the group with both diabetes and Charcot neuroarthropathy. Conclusions: Based on the results of this study, given the importance of vitamin D in bone metabolism and the osseous consequences associated with diabetes, as well as other systems affected by low levels of vitamin D in the diabetic patient, it appears that vitamin D levels should be monitored in diabetic patients. (J Am Podiatr Med Assoc 99(1): 35–41, 2009)

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