Challenge-confirmed peanut allergy in older patients: Performance of skin tests, specific immunoglobulin E, and ara h 2

AbstractSpecific immunoglobulin E to Ara h 2 (sIgE to Ara h 2) is described as an upcoming predicting factor for diagnosing peanut allergy in children. The gold standard for diagnosing peanut allergy is a double blind placebo controlled food challenge, however this is time consuming and potentially harmful. We investigate Ara h 2 as a preliminary less invasive diagnostic tool for diagnosing peanut allergy in a general population of peanut sensitized children.Children (n=52) with peanut sensitization were retrospectively included. An oral food challenge (OFC) confirmed peanut allergy or tolerance, as primary outcome. Individual candidate predictors were identified by univariate regression analysis and used in a prediction model. Different cut-off values were obtained and receiver operating characteristic curves were plotted.Multivariate analyses resulted in Ara h 2 as best predictor, with a discriminative ability of 0.87 (95% confidence interval, 0.77–0.97). Sensitivity and specificity of 55% and 95%, respectively, were found for a sIgE to Ara h 2 cut-off value of 4.25 kU/L. The highest positive predictive value of 100% was reached at 5.61 kU/L. No absolute relation was found between the value of Ara h 2 and the severity of the reaction during OFC.This study developed a prediction model in which sIgE to Ara h 2 was the best predictor for peanut allergy in sensitized children in a general hospital. Therefore depending on the history and the Ara h 2 results, an OFC is not always needed to confirm the diagnosis.

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ASSESSMENT OF PATIENTS WHO HAVE EXPERIENCED ANAPHYLAXIS: A 3-YEAR SURVEY

PEDIATRICS ◽

10.1542/peds.96.2.384 ◽

1995 ◽

Vol 96 (2) ◽

pp. 384-384

Author(s):

Hugh A. Sampson

Keyword(s):

Emergency Treatment ◽

Immunoglobulin E ◽

Positive Test ◽

Skin Tests ◽

Test Results ◽

Detailed History ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

History Of

The authors concluded that a minimal workup for anaphylaxis should include elicitation of a detailed history of allergic episodes, performance of prick skin tests or quantification of allergen-specific immunoglobulin E(IgE), further exploration of any positive test results, and regular follow-up of all patients to gauge the success of avoidance and emergency treatment.

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Optimal cutoff values of allergen-specific immunoglobulin E to house dust mites and animal dander based on skin-prick test results: Analysis in 16,209 patients with allergic rhinitis

American Journal of Rhinology and Allergy ◽

10.2500/ajra.2017.31.4483 ◽

2017 ◽

Author(s):

S. D. Hong ◽

G. Ryu ◽

M. Y. Seo ◽

J. I. Jeong ◽

H. Y. Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Immunoglobulin E ◽

House Dust Mites ◽

Test Results ◽

Dust Mites ◽

Optimal Cutoff ◽

Prick Test ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Animal Dander

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Prevention of food allergy

Allergy and Asthma Proceedings ◽

10.2500/aap.2019.40.4269 ◽

2019 ◽

Vol 40 (6) ◽

pp. 450-452 ◽

Cited By ~ 1

Author(s):

Ashley L. Devonshire ◽

Rachel Glick Robison

Keyword(s):

Food Allergy ◽

Peanut Allergy ◽

Immunoglobulin E ◽

Skin Prick Testing ◽

Clinical Manifestations ◽

Conclusive Evidence ◽

Severe Atopic Dermatitis ◽

Early Introduction ◽

Infant Diet ◽

Specific Immunoglobulin E

Primary prevention and secondary prevention in the context of food allergy refer to prevention of the development of sensitization (i.e., the presence of food-specific immunoglobulin E (IgE) as measured by skin-prick testing and/or laboratory testing) and sensitization plus the clinical manifestations of food allergy, respectively. Until recently, interventions that target the prevention of food allergy have been limited. Although exclusive breast-feeding for the first 6 months of life has been a long-standing recommendation due to associated health benefits, recommendations regarding complementary feeding in infancy have significantly changed over the past 20 years. There now is evidence to support early introduction of peanut into the diet of infants with egg allergy, severe atopic dermatitis, or both diagnoses, defined as high risk for peanut allergy, to try to prevent development of peanut allergy. Although guideline-based recommendations are not available for early introduction of additional allergenic foods, this topic is being actively studied. There is no evidence to support additional dietary modification of the maternal or infant diet for the prevention of food allergy. Similarly, there is no conclusive evidence to support maternal avoidance diets for the prevention of food allergy.

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Allergic diseases attributable to atopy in a population sample of Asian children

Scientific Reports ◽

10.1038/s41598-021-95579-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chao-Yi Wu ◽

Hsin-Yi Huang ◽

Wen-Chi Pan ◽

Sui-Ling Liao ◽

Man-Chin Hua ◽

...

Keyword(s):

Immunoglobulin E ◽

Population Attributable Risk ◽

Population Sample ◽

International Study ◽

Allergic Diseases ◽

Population Based ◽

School Age Children ◽

Specific Immunoglobulin E ◽

Asian Children ◽

Specific Immunoglobulin

AbstractThe proportion of allergic diseases attributable to atopy remains a subject of controversy. This study aimed to estimate the population risk of physician-diagnosed asthma, rhinitis and eczema attributed to atopy among a population sample of Asian school-age children. Asian children aged 5–18 years (n = 1321) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were tested for serum allergen-specific immunoglobulin E. Physician-diagnosed asthma, rhinitis and eczema were assessed by a modified International Study of Asthma and Allergies in Childhood questionnaire. Atopy was defined as the presence of serum allergen-specific immunoglobulin E. In this population-based study, 50.4% of the subjects with asthma, 46.3% with rhinitis, and 46.7% with eczema were attributable to atopy. The population attributable risk (PAR) of atopy for three allergic diseases was higher in adolescents (asthma, 54.4%; rhinitis, 59.6%; eczema, 49.5%) than younger children aged less than 10 years (asthma, 46.9%; rhinitis, 39.5%; eczema, 41.9%). Among the seven allergen categories, sensitization to mites had the highest PARs for all three allergic diseases (51.3 to 64.1%), followed by sensitization to foods (asthma, 7.1%; rhinitis, 10.4%; eczema 27.7%). In conclusion, approximately half (46.3 to 50.4%) of Asian children in Taiwan with allergic diseases are attributable to atopy.

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Effect of Specific Immunoglobulin E Response and Comorbidities on Effectiveness of MP-AzeFlu in a Real-Life Study

International Archives of Allergy and Immunology ◽

10.1159/000508749 ◽

2020 ◽

Vol 181 (10) ◽

pp. 754-764

Author(s):

Ludger Klimek ◽

David Price ◽

Gabriella Gálffy ◽

Melanie Emmeluth ◽

Arkady Koltun ◽

...

Keyword(s):

Immunoglobulin E ◽

Real Life ◽

Life Study ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Real Life Study

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Total and Specific Immunoglobulin E and Their Relationship to Respiratory Symptoms in Quebec Children and Adolescents

Canadian Respiratory Journal ◽

10.1155/2005/248714 ◽

2005 ◽

Vol 12 (8) ◽

pp. 426-432 ◽

Cited By ~ 6

Author(s):

Benoît Levesque ◽

Jean-François Duchesne ◽

Suzanne Gingras ◽

Pierre Allard ◽

Edgar Delvin ◽

...

Keyword(s):

Children And Adolescents ◽

Respiratory Symptoms ◽

Immunoglobulin E ◽

Geometric Mean ◽

Allergic Sensitization ◽

Population Sample ◽

Ethnic Origin ◽

Total Ige ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

BACKGROUND: Respiratory disease is a major cause of morbidity in young people. It is now recognized that atopy plays an important role in the development of chronic respiratory symptoms in children.OBJECTIVE: To examine the determinants and consequences of serum total and specific immunoglobulin E (IgE) in a general population sample of Québec children and adolescents.METHODS: In 1999, 2349 children and adolescents (nine, 13 or 16 years of age) who had participated in a respiratory symptom and disease questionnaire had their total IgE measured. Of these participants, a subsample of 451 children and adolescents was analyzed to detect antibodies to eight specific allergens (ie, allergens of dust mites [Dermatophagoides farinae and Dermatophagoides pteronyssinus], cat, dog, ragweed, Timothy grass, mould [alternaria] and cockroach).RESULTS: The geometric mean of the total IgE was 44.4 U/mL among all participants. Concentrations were higher in boys and increased with age. More than 41% of the participants were sensitized to at least one specific allergen. Such sensitization was strongly associated with the occurrence of respiratory conditions and symptoms, namely asthma, wheezing and rhinitis. Family history, school location and ethnic origin had an impact on the prevalence of atopy and total IgE levels.CONCLUSIONS: Allergic sensitization is a major determinant in the development of asthma, wheezing and rhinitis in children and adolescents in the province of Québec.

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