Impact of RASSF1A gene methylation on clinico-pathological features of tumor and non-tumor tissue of breast cancer

2021 ◽  
Vol 52 ◽  
pp. 151722
Author(s):  
Vivek Gupta ◽  
Prerna Agarwal ◽  
Prajakta Deshpande
Keyword(s):  
Breast Cancer ◽  
Tumor Tissue ◽  
Pathological Features ◽  
Gene Methylation ◽  
Rassf1a Gene

scholarly journals Impact of RASSF1A gene methylation on the metastatic axillary nodal status in breast cancer patients

2017 ◽  
Vol 14 (1) ◽  
pp. 758-766 ◽  
Author(s):  
Eva Jezkova ◽  
Pavol Zubor ◽  
Karol Kajo ◽  
Marian Grendar ◽  
Karol Dokus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Nodal Status ◽  
Breast Cancer Patients ◽  
Gene Methylation ◽  
Rassf1a Gene

scholarly journals Intra-mammary lymph nodes, an overlooked breast cancer prognostic tool?

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tarek Hashem ◽  
Ahmed Abdelmoez ◽  
Ahmed Mohamed Rozeka ◽  
Hazem Abdelazeem
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Percutaneous Biopsy ◽  
Preoperative Imaging ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pathological Features ◽  
Breast Cancer Patients ◽  
Surgical Data

Abstract Background Due to the high variability of incidence and prevalence of intra-mammary lymph nodes (IMLNs), they might be overlooked during clinical and radiological examinations. Properly characterizing pathological IMLNs and detecting the factors that might influence their prevalence in different stages of breast cancer might aid in proper therapeutic decision-making and could be of possible prognostic value. Methods Medical records were reviewed for all breast cancer patients treated at the National Cancer Institute of Cairo University between 2013 and 2019. Radiological, pathological, and surgical data were studied. Results Intra-mammary lymph nodes were described in the final pathology reports of 100 patients. Five cases had benign breast lesion. Three cases had phyllodes tumors and two cases had ductal carcinoma in situ (DCIS). All ten cases were excluded. The remaining 90 cases all had invasive breast cancer and were divided into two groups: one group for patients with malignant IMLNs (48) and another for patients with benign IMLNs (42). Pathological features of the malignant IMLN group included larger mean tumor size in pathology (4.7 cm), larger mean size of the IMLN in pathology (1.7 cm), higher incidence of lympho-vascular invasion (65.9%), and higher rate of extracapsular extension in axillary lymph nodes (57.4%). In addition, the pathological N stage was significantly higher in the malignant IMLN group. Conclusion Clinicians frequently overlook intra-mammary lymph nodes. More effort should be performed to detect them during preoperative imaging and during pathological processing of specimens. A suspicious IMLN should undergo a percutaneous biopsy. Malignant IMLNs are associated with advanced pathological features and should be removed during surgery.

hERG1 channel expression in breast cancer: Association with molecular parameters, pathological features and survival

2018 ◽  
Vol 92 ◽  
pp. S140-S141
Author(s):  
E. Lastraioli ◽  
J. Iorio ◽  
I. Meattini ◽  
M. Bernini ◽  
L. Dominici ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pathological Features ◽  
Molecular Parameters ◽  
Channel Expression ◽  
Herg1 Channel

scholarly journals Cancers in Togo from 1984 to 2008: Epidemiological and Pathological Aspects of 5251 Cases

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Koffi Amégbor ◽  
Tchin Darre ◽  
Koffi Didier Ayéna ◽  
Essohana Padaro ◽  
Kodjo Tengué ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Gastric Cancer ◽  
Skin Cancer ◽  
Sex Ratio ◽  
Average Frequency ◽  
Pathological Features ◽  
Annual Average ◽  
Cancer Register ◽  
Non Hodgkin Lymphoma

Objective. To describe the epidemiological and histological aspects of cancers in Togo.Materials and Methods. We made a retrospective review of the epidemiological and pathological features of cancers observed from 1984 to 2008 at the laboratory of pathology of CHU-TOKOIN in Lomé, Togo.Results. During our study period, we found 5251 cases of cancers with an annual average frequency of 210 cases. The sex ratio, male/female, was 0.9 and the average age of occurring was 45.3 years. This average age was 46.9 years for men and 43.8 years for women. The most frequent cancers for men were prostate cancer (12.9%), nonmelanoma skin cancer (10.4%), and gastric cancer (10.3%). For women it was breast cancer (27.1%), cervix cancer (11.2%) and non-Hodgkin lymphoma (6.3%). Histologically, it was carcinomas in 68.1% of the cases, sarcomas in 11% of the cases and non-Hodgkin lymphomas in 12.6% of the cases. Children cancers were primarily Burkitt lymphoma (27.9% of cases) and retinoblastoma (8.5% of cases).Conclusion. This study shows that cancers are frequent in Togo and emphasizes on the necessity of having a cancer register for the prevention and the control of this disease in Togo.

scholarly journals Adenomatous Polyposis Coli and Ras Association Domain Family 1A Gene Methylation in Breast Cancer Patients

2007 ◽  
Vol 10 (2) ◽  
pp. 120
Author(s):  
Il-kyung Park ◽  
Jee-Soo Yim ◽  
Yu-Mi Ra ◽  
Dae-gyung Ko ◽  
In-seok Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Adenomatous Polyposis Coli ◽  
Adenomatous Polyposis ◽  
Breast Cancer Patients ◽  
Polyposis Coli ◽  
Domain Family ◽  
Gene Methylation

scholarly journals Methylation of the NT5E Gene Is Associated with Poor Prognostic Factors in Breast Cancer

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 939
Author(s):  
Young Ju Jeong ◽  
Hoon Kyu Oh ◽  
Hye Ryeon Choi ◽  
Sung Hwan Park
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Methylation Status ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Receptor Expression ◽  
Gene Methylation ◽  
Clinicopathologic Characteristics ◽  
Large Tumor ◽  
The Mean

Cluster of differentiation (CD) 73, which is encoded by the NT5E gene, regulates production of immunosuppressive adenosine and is an emerging checkpoint in cancer immunotherapy. Despite the significance of CD73 in immuno-oncology, the roles of the NT5E gene methylation in breast cancer have not been well-defined yet. Therefore, we aimed to investigate the prognostic significance of the NT5E gene methylation in breast cancer. The DNA methylation status of the NT5E gene was analyzed using pyrosequencing in breast cancer tissues. In addition, the levels of inflammatory markers and lymphocyte infiltration were evaluated. The mean methylation level of the NT5E gene was significantly higher in breast cancer than in normal breast tissues. In the analysis of relevance with clinicopathologic characteristics, the mean methylation levels of the NT5E gene were significantly higher in patients with large tumor size, high histologic grade, negative estrogen receptor expression, negative Bcl-2 expression, and premenopausal women. There was no difference in disease-free survival according to the methylation status of the NT5E gene. We found that the NT5E gene methylation was related to breast cancer development and associated with poor prognostic factors in breast cancer. Our results suggest that the NT5E gene methylation has potential as an epigenetic biomarker in breast cancer.

scholarly journals Male Breast Cancer: Clinical, Demographical, and Pathological Features in a Cohort of 41 Patients

Cureus ◽  
2021 ◽  
Author(s):  
Tolga Koseci ◽  
Veysel Haksöyler ◽  
Polat Olgun ◽  
Mahmut Bakır Koyuncu ◽  
Berna Bozkurt Duman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Male Breast ◽  
Pathological Features
Sign in / Sign up

Export Citation Format

Share Document