Primary mediastinal germ cell tumours with high prevalence of somatic malignancy: An experience from a single tertiary care oncology centre

2021 ◽  
pp. 151763
Author(s):  
Arshi Beg ◽  
Rajiv Kumar ◽  
Ayushi Sahay ◽  
Amit Janu ◽  
Amit Joshi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Tertiary Care ◽  
Germ Cell Tumours ◽  
High Prevalence ◽  
Oncology Centre

1034 HIGH PREVALENCE AND INTERACTION OF HYPOGONADISM AND THE METABOLIC SYNDROME IN LONG-TERM SURVIVORS WITH GERM CELL TUMOURS

2011 ◽  
Vol 10 (2) ◽  
pp. 320
Author(s):  
F. Gottardo ◽  
L. Grunwald ◽  
S. Secker ◽  
M. Zitzmann ◽  
G. Gerhard ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Germ Cell ◽  
Germ Cell Tumours ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Long Term Survivors

scholarly journals HCP-02EXPERIENCE WITH MANAGEMENT OF GERM CELL TUMOURS IN TERTIARY CARE CENTRE IN EASTERN INDIA

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v101.2-v101
Author(s):  
Gopal Achari ◽  
Rimpa Basu Achari ◽  
Uttara Chatterji ◽  
Sandip Chatterji
Keyword(s):  
Germ Cell ◽  
Tertiary Care ◽  
Germ Cell Tumours ◽  
Care Centre ◽  
Eastern India ◽  
Tertiary Care Centre

scholarly journals Incidence of malignant mixed ovarian germ cell tumours in a tertiary care hospital: A five year retrospective study

2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Emilio M Treviño-Salinas ◽  
Karen A Pinto-García ◽  
José G Garza-Leal ◽  
Oralia Barboza-Quintana ◽  
Gabriela García-Tamez ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Germ Cell ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Germ Cell Tumours

scholarly journals Germ Cell Tumours- A Histopathological Evaluation of Eighty Cases in a Tertiary Care Institution of Eastern India

2020 ◽  
Vol 7 (26) ◽  
pp. 1234-1238
Author(s):  
Rajashree Tripathy ◽  
Nibedita Sahoo ◽  
Prateek Das ◽  
Sujata Naik ◽  
Anasuya Lenka
Keyword(s):  
Germ Cell ◽  
Tertiary Care ◽  
Germ Cell Tumours ◽  
Eastern India ◽  
Care Institution ◽  
Histopathological Evaluation ◽  
Tertiary Care Institution

scholarly journals The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1325
Author(s):  
Abhisek Ghosh ◽  
Korsuk Sirinukunwattana ◽  
Nasullah Khalid Alham ◽  
Lisa Browning ◽  
Richard Colling ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Testicular Cancer ◽  
Germ Cell ◽  
Lymphovascular Invasion ◽  
Automatic Segmentation ◽  
Prognostic Significance ◽  
Germ Cell Tumours ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Whole Slide Images

Testicular cancer is the most common cancer in men aged from 15 to 34 years. Lymphovascular invasion refers to the presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown to have prognostic significance in testicular germ cell tumours. In non-seminomatous tumours, lymphovascular invasion is the most powerful prognostic factor for stage 1 disease. For the pathologist, searching multiple slides for lymphovascular invasion can be highly time-consuming. The aim of this retrospective study was to develop and assess an artificial intelligence algorithm that can identify areas suspicious for lymphovascular invasion in histological digital whole slide images. Areas of possible lymphovascular invasion were annotated in a total of 184 whole slide images of haematoxylin and eosin (H&E) stained tissue from 19 patients with testicular germ cell tumours, including a mixture of seminoma and non-seminomatous cases. Following consensus review by specialist uropathologists, we trained a deep learning classifier for automatic segmentation of areas suspicious for lymphovascular invasion. The classifier identified 34 areas within a validation set of 118 whole slide images from 10 patients, each of which was reviewed by three expert pathologists to form a majority consensus. The precision was 0.68 for areas which were considered to be appropriate to flag, and 0.56 for areas considered to be definite lymphovascular invasion. An artificial intelligence tool which highlights areas of possible lymphovascular invasion to reporting pathologists, who then make a final judgement on its presence or absence, has been demonstrated as feasible in this proof-of-concept study. Further development is required before clinical deployment.

scholarly journals 86 Gliomatosis peritonei associated with ovarian germ cell tumours- a clinicopathological case series

2020 ◽  
Author(s):  
A Jayraj ◽  
S Kumar ◽  
N Bhatla ◽  
S Thulkar ◽  
S Thulkar ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Series ◽  
Germ Cell Tumours ◽  
Gliomatosis Peritonei

scholarly journals GCT-65. INCIDENCE AND OUTCOME OF INTRACRANIAL MALIGNANT GERM CELL TUMOURS DIAGNOSED IN WESTERN DENMARK IN THE LAST DECADE

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii341-iii341
Author(s):  
Yasmin Lassen-Ramshad ◽  
Torben Stamm Mikkelsen ◽  
Steen Rosthoej ◽  
Louise Tram Henriksen ◽  
Ruta Tuckuvienne ◽  
...  
Keyword(s):  
Germ Cell ◽  
Chart Review ◽  
Recurrent Disease ◽  
High Dose Chemotherapy ◽  
Salvage Treatment ◽  
High Dose ◽  
Germ Cell Tumours ◽  
Younger Adults ◽  
Multidrug Chemotherapy ◽  
Disseminated Disease

Abstract INTRODUCTION Intracranial malignant germ cell tumours (iGCT) are rare brain tumours mainly diagnosed in children and younger adults. MATERIAL AND METHODS A retrospective analysis was performed by chart review of patients treated for iGCT in the northern and central region of Denmark. Teratoma only patients were not included in the study. RESULTS 20 patients with iGCT were diagnosed from 2008–2019 in Western Denmark. The cumulative incidence was 1.05 per 100.000. The yearly incidence was 0.1 per 100.000. Mean age at diagnosis was 18 years (range 8–36 years), 17 were males and 3 were females. 13 patients presented with germinoma and 7 patients with non germinomateous germ cell tumours (NGGCT). Three patients had disseminated disease, two with germinoma and one with NGGCT. All patients had received radiotherapy and 18 patients were treated with multidrug chemotherapy including platinum and etoposide before irradiation. Two patients experienced recurrent disease, both non disseminated at diagnosis, one patient with germinoma and one patient with NGGCT. Both received salvage treatment including high dose chemotherapy with stem cell transplantation and reirradiation. Two NGGCT patients died, one patient after development of an anaplastic astrocytoma in the radiation field five years after radiotherapy and one patient after intracranial hemorraghe 18 months after salvage treatment for recurrent disease. Overall survival was 90%, 100% for GCT and 71% for NGGCT. CONCLUSION The outcome of patients with iGCT in Western Denmark was comparable to the literature. A nationwide study of epidemiology and outcome of iGCT in Denmark is planned.

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