Prediction of occupational exposure limits for noise-induced non-auditory effects

2022 ◽  
Vol 99 ◽  
pp. 103641
Author(s):  
Rostam Golmohammadi ◽  
Ebrahim Darvishi ◽  
Masoud Shafiee Motlagh ◽  
Javad Faradmal ◽  
Mohsen Aliabadi ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Occupational Exposure Limits ◽  
Exposure Limits

scholarly journals Possible hazards of work environment in metal processing industry in Latvia

2010 ◽  
Vol 64 (1-2) ◽  
pp. 61-65
Author(s):  
Inese Mārtiņsone ◽  
Mārīte-Ārija Baķe ◽  
Žanna Martinsone ◽  
Maija Eglīte
Keyword(s):  
Risk Factors ◽  
Occupational Exposure ◽  
Work Environment ◽  
Occupational Safety ◽  
Poor Quality ◽  
Occupational Exposure Limits ◽  
Exposure Limits ◽  
Processing Industry ◽  
Metal Processing ◽  
Metal Processing Industry

Possible hazards of work environment in metal processing industry in Latvia The aim of this study was to investigate risk factors in the work environment of Latvian metal processing industry using the database of the Laboratory of Hygiene and Occupational Diseases of the Institute of Occupational Safety and Environmental Health, Rīga Stradiņš University. During the period between 1996 and 2005, 703 measurements were made in metalworking enterprises. In Latvia, approximately 2.4% of the workforce is involved in the metal processing industry. Physical (noise, lighting, vibration) and chemical (abrasive dust, welding aerosol and contained metals) risk factors were analysed. In the assessed metalworking workplaces, the work environment was estimated to be of poor quality, because occupational exposure limits or recommended values were exceeded in 42% (n = 294) of cases. Noise, manganese and welding aerosols most often exceeded the occupational exposure limits or recommended values, the significance was P < 0.001, P < 0.01 and P < 0.05, respectively.

scholarly journals Setting occupational exposure limits for antimicrobial agents: A case study based on a quaternary ammonium compound-based disinfectant

2020 ◽  
Vol 36 (9) ◽  
pp. 619-633
Author(s):  
G Scott Dotson ◽  
Jason T Lotter ◽  
Rachel E Zisook ◽  
Shannon H Gaffney ◽  
Andrew Maier ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Quaternary Ammonium ◽  
Antimicrobial Agents ◽  
Weight Of Evidence ◽  
Ammonium Compound ◽  
Occupational Exposure Limits ◽  
Exposure Limits ◽  
Viral Pathogen ◽  
Selection Of

Antimicrobial agents have become an essential tool in controlling the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and guidelines on their use have been issued by various public health agencies. Through its Emerging Viral Pathogen Guidance for Antimicrobial Pesticides, the US Environmental Protection Agency has approved numerous surface disinfectant products for use against SARS-CoV-2. Despite their widespread use and range of associated health hazards, the majority of active ingredients in antimicrobial products, such as surface disinfectants, lack established occupational exposure limits (OELs) to assist occupational health professionals in characterizing risks from exposures to these chemicals. Based on established approaches from various organizations, a framework for deriving OELs specific to antimicrobial agents was developed that relies on a weight-of-evidence evaluation of the available data. This framework involves (1) a screening-level toxicological assessment based on a review of the existing literature and recommendations, (2) identification of the critical adverse effect(s) and dose–response relationship(s), (3) identification of alternative health-based exposure limits (HBELs), (4) derivation of potential OELs based on identified points of departure and uncertainty factors and/or modification of existing alternative HBELs, and (5) selection of an appropriate OEL. To demonstrate the use of this framework, a case study is described for selection of an OEL for a disinfectant product containing quaternary ammonium compounds (quats). Three potential OELs were derived for this product based on irritation toxicity data, developmental and reproductive toxicity (DART) data, and modification of an existing HBEL. The final selected OEL for the quats-containing product was 0.1 mg/m3, derived from modification of an existing HBEL. This value represented the lowest resulting value of the three approaches, and thus, was considered protective of irritation and potential DART.

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