scholarly journals Carbonation of borehole seals: Comparing evidence from short-term laboratory experiments and long-term natural analogues

2013 ◽  
Vol 30 ◽  
pp. 161-177 ◽  
Author(s):  
Christopher A. Rochelle ◽  
Antoni E. Milodowski
1997 ◽  
Vol 506 ◽  
Author(s):  
W. Russell Alexander ◽  
Andreas Gautschi ◽  
Piet Zuidema

ABSTRACTRepositories have to isolate radioactive waste (radwaste) and some toxic wastes from the environment for hundreds to hundreds of thousands of years. For many scientists and engineers, and especially the general public, such time spans are beyond comprehension and, consequently, they have grave doubts as to the safety of any such waste repositories. That repository performance over these long time scales can only be assessed by the use of complex mathematical models (normally called performance assessment, or PA, models) only adds to the mistrust of many. How then can people be convinced that it is possible to assess the performance (and thus ensure the safety) of a repository over the long timescales of interest? One way is to address the robustness of the PA models, by clearly indicating the form and extent of model testing carried out within the repository PA. Not only can this show that the individual component parts of the complex structure which constitutes most PA models have been checked, but also that the ‘mathematical black boxes’ constitute an acceptabe representation of the repository system.Part of the problem undoubtedly lies in the unusual nature of radwaste disposal: in most major engineering projects, such as bridge construction or aerospace engineering, the designs are tested against a range of laboratory experiments backed up by expert judgement based on experience with the same or similar systems. Here repository design deviates from standard engineering practice in that no high-level waste (and only a few low- and intermediate-level waste) repositories yet exist and, even when they do, testing their compliance to design limits will be somewhat difficult due to the time scales involved. In addition, the irrational fear of most things radioactive means that most people require some greater form of ‘proof’ that a repository is safe than they are willing to accept for other engineered systems. This being the case, significant additional effort must be expended within the radwaste industry to make it completely clear that the PA models can adequately predict the long-term behaviour of a repository.Traditionally, PA modellers have placed much weight on laboratory data for the construction and testing of PA models and, with only a few exceptions, have not integrated in their PA reports data from natural analogues and in situ experiments. The over-dependence on laboratory data is understandable in that the information is produced under well understood, fully controlled conditions and thus the modellers feel they can place a high degree of confidence in the results obtained. Unfortunately, the full complexity of a repository cannot be re-created in a laboratory and it is necessary to address processes which are influenced by natural heterogeneities, which include large degrees of uncertainty and which operate over very long timescales. In this case, it is necessary to supplement laboratory data with information from in situ field experiments and natural analogues.The advantage of natural analogues over short-term laboratory experiments is that they enable study of repository-like systems which have evolved over the geological timescales of relevance to a radwaste repository safety assessment (rather than the days to months usual in laboratory tests). However, by their very nature, natural analogues often have ill-defined boundary conditions which may be better assessed under the well constrained (if less relevant) conditions of a laboratory. Well designed, realistic in situ field experiments can bridge the gap between the laboratory and natural analogues by offering repository relevant natural conditions with some of the constraints of the laboratory (and intermediate timescales). In short, combining information from the three sources (long-term and realistic, if poorly defined, natural analogues, medium-term, better constrained, in situ field experiments and short-term, less realistic but well defined laboratory studies) can provide greater confidence in the extrapolation of laboratory derived data to repository relevant timescales and conditions.This paper will concentrate on presenting a model testing scheme which both promotes transparency (for the sake of technical peer reviewers and the general public alike) and which aims at a thorough test of PA models. In addition, several recently published PAs will be critically examined and the form, extent and transparency of testing will be discussed with a view to improving confidence in the robustness of the models and thus the perceived safety of specific radwaste repository designs.


Author(s):  
G. Bracke ◽  
W. Mu¨ller

Gas generation is a safety issue for repositories for radioactive waste because of its potential impact on barrier integrity and radionuclide transport. Therefore, the amount of gas that might be produced and the generation rate has to be assessed. For a qualified prediction of the gas generation potential and rates under repository conditions for radiolysis, corrosion and microbial degradation, gas generation rates concerning real waste packages, laboratory experiments as well as natural analogues for microbial degradation have been evaluated. These data were applied to long-term modelling of gas generation at two sites. The modelling includes aerobic, anaerobic, dry and saturated phases and variations of pH depending on the degradation of cement in order to assess the range of gas generation rates. The results show very low gas generation by radiolysis. At one site, radiolytic gas generation was dominated by short-lived nuclides. The other site had a larger inventory of long-lived radionuclides, yielding higher long-term radiolytic gas generation. In contrast to previous calculations, the gas generation potential by microbial degradation was significantly lower than calculated by stoechiometry. The microbial gas generation potential is reduced by microbial degradation before closure of the site. Furthermore a saturation effect, known from natural analogues, waste dumps and experiments, was modelled, resulting in a significantly lower yield of gas. Overall, the gas generation potential and rate were dominated by corrosion processes of iron.


2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.


Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.


2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607


2019 ◽  
Vol 25 ◽  
pp. 114
Author(s):  
Alyssa Dufour ◽  
Setareh Williams ◽  
Richard Weiss ◽  
Elizabeth Samelson

2017 ◽  
Vol 23 ◽  
pp. 50
Author(s):  
Jothydev Kesavadev ◽  
Shashank Joshi ◽  
Banshi Saboo ◽  
Hemant Thacker ◽  
Arun Shankar ◽  
...  

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