This paper investigates the size-dependent nonlinear bending of functionally graded carbon nanotube-reinforced (FG-CNTR) nanobeams. Chen–Yao’s surface elasticity and modified couple stress theories are adopted to describe surface effects and couple stress effects, respectively. These nanobeams, in which the carbon nanotube (CNT)-reinforced phases are assumed to be distributed in a gradient along the thickness, are subjected to a uniform pressure and rest on a nonlinear elastic foundation. In accordance with the Euler–Lagrange variational principle, the governing equations and boundary conditions for the FG-CNTR nanobeams, which involve geometric nonlinearity due to the von Kármán strain relations, are obtained. Then, with the assistance of the two-step perturbation technique, the load-deflection relationship is determined for nanobeams subjected to simply supported (SS) and clamped–clamped (CC) boundary conditions. Finally, the impacts of various factors, including surface properties, characteristic material length, elastic foundation, geometric factors, layout type and volume fraction of CNTs, on the mechanical behaviors of CNT-based nanobeams are examined. The numerical results reveal that the combination of surface effects and couple stress helps to enhanceq the stiffness of the nanobeams. Furthermore, the size-dependent nonlinear bending of the FG-CNTR nanobeam is markedly affected by the content and layout type of the reinforcements.