The present work aims to study the non-linear vibrations in a cracked orthotropic tapered micro-plate. Linear and parabolic variation in the plate thickness is assumed in one as well as two directions. The partial crack is located in the centre, and it is continuous; this crack’s location is arbitrary and can be varied within the centre-line. Based on classical plate theory, the equilibrium principle is applied, and the governing equation of tapered orthotropic plate is derived. Additionally, the microstructure’s effect has been included in the governing equation using the non-classical modified couple stress theory. The simplified line spring model is used to consider the impact of partial crack on the plate dynamics and is incorporated using in-plane forces and bending moments. The introduction of Berger’s formulation brings the non-linearity in the model in terms of in-plane forces. Here, Galerkin’s method has been chosen for converting the derived governing equation into time-dependent modal coordinates, which uses an approximate solution technique to solve the non-linear Duffing equation. The crack is considered along the fibres and across the fibres to show the effect of orthotropy. Results are presented for an orthotropic cracked plate with non-uniform thickness. The effects of the variation of taper constants, crack location, crack length, internal material length scale parameter on the fundamental frequency are obtained for two different boundary conditions. The non-linear frequency response curves are plotted to show the effect of non-linearity on the system dynamics using the method of multiple scales, and the contribution of taper constants and crack parameters on non-linearity is shown with bending-hardening and bending-softening phenomenon. It has been found that vibration characteristics are affected by the taper parameters and fibre direction for a cracked orthotropic plate.