An intracellular enzyme-responsive polymeric prodrug with synergistic effect of chemotherapy and two-photon photodynamic therapy

2021 ◽  
Vol 23 ◽  
pp. 100996
Author(s):  
Lei Luo ◽  
Zhen Yin ◽  
Yiming Qi ◽  
Shuang Liu ◽  
Yong Yi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Synergistic Effect ◽  
Intracellular Enzyme ◽  
Two Photon ◽  
Polymeric Prodrug

Biocompatible well-defined chromophore–polymer conjugates for photodynamic therapy and two-photon imaging

2013 ◽  
Vol 4 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Cristina Cepraga ◽  
Thibault Gallavardin ◽  
Sophie Marotte ◽  
Pierre-Henri Lanoë ◽  
Jean-Christophe Mulatier ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Polymer Conjugates ◽  
Photon Imaging ◽  
Two Photon Imaging

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

Rational fabrication of two-photon responsive metal-organic framework for enhanced photodynamic therapy

2021 ◽  
Author(s):  
Xin Yao ◽  
Xinxin Pei ◽  
Bo Li ◽  
Mengqi Lv ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Rational Design ◽  
Metal Organic Framework ◽  
Cancer Treatments ◽  
Two Photon ◽  
Metal Organic ◽  
Organic Framework

Rational design of specific platform which can address the unavoidable side effects of traditional cancer treatments is of great interest. In this sense, herein, an intelligent nanoplatform (ZnL1@MOF-199@FA) with efficient...

Biocompatible fluorenylphthalocyanines for one and two-photon photodynamic therapy and fluorescence imaging

2021 ◽  
pp. 109840
Author(s):  
Seifallah Abid ◽  
Christophe Nguyen ◽  
Morgane Daurat ◽  
Denis Durand ◽  
Bassem Jamoussi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Two Photon

Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy

Nanoscale ◽  
2012 ◽  
Vol 4 (24) ◽  
pp. 7712 ◽  
Author(s):  
Tingting Zhao ◽  
Xiaoqin Shen ◽  
Lin Li ◽  
Zhenping Guan ◽  
Nengyue Gao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Imaging Agents ◽  
Two Photon

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

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