Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment

The aim of this experimental study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, on cisplatin-induced hepatotoxicity through adenosine deaminase (AD), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) and nitric oxide (NO) levels in liver tissue of rats. Wistar albino rats were divided into three groups: control group (n-6), cisplatin group (n-9) and CAPE+cisplatin group (n-8). All the chemicals used were applied intraperitoneally. Spectrophotometric methods were used to determine the activities of the above-mentioned enzymes in the liver tissue. NO level and XO activity were found to be increased in the cisplatin group compared to the control group. NO level was found to be decreased in the cisplatin+CAPE group in comparison with the cisplatin group. There was no significant change in the activity of XO between the cisplatin and cisplatin+CAPE groups. The activity of SOD was lower in the cisplatin group than both the control and cisplatin+CAPE groups. There was no significant change in the activity of CAT between the control and cisplatin groups. CAT activity was increased in the cisplatin+CAPE group compared to the cisplatin group. The AD activity and MDA level remained unchanged in all groups. The results obtained suggested that CAPE significantly attenuated the hepatotoxicity as an indirect target of cisplatin in an animal model of cisplatin-induced nephrotoxicity.

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Hypothalamic superoxide dismutase, xanthine oxidase, nitric oxide, and malondialdehyde in rats fed with fish ω-3 fatty acids

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2004.05.006 ◽

2004 ◽

Vol 28 (4) ◽

pp. 693-698 ◽

Cited By ~ 35

Author(s):

Ahmet Songur ◽

Mustafa Sarsilmaz ◽

Sadik Sogut ◽

Birsen Ozyurt ◽

Huseyin Ozyurt ◽

...

Keyword(s):

Nitric Oxide ◽

Fatty Acids ◽

Superoxide Dismutase ◽

Xanthine Oxidase

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Adenosine deaminase, xanthine oxidase, uric acid, and nitric oxide metabolism in the pathogenesis of disease in patients with colon polyps

Dicle Medical Journal / Dicle Tip Dergisi ◽

10.5798/diclemedj.0921.2014.01.0379 ◽

2014 ◽

Vol 41 (1) ◽

pp. 90-94

Author(s):

Rafet Mete ◽

Keyword(s):

Nitric Oxide ◽

Uric Acid ◽

Xanthine Oxidase ◽

Adenosine Deaminase ◽

Colon Polyps ◽

Nitric Oxide Metabolism

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The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity

Toxicology and Industrial Health ◽

10.1191/0748233705th255oa ◽

2006 ◽

Vol 22 (3) ◽

pp. 125-130 ◽

Cited By ~ 33

Author(s):

Mukaddes Gulec ◽

Mustafa Iraz ◽

H Ramazan Yilmaz ◽

Huseyin Ozyurt ◽

Ismail Temel

Keyword(s):

Nitric Oxide ◽

Renal Failure ◽

Xanthine Oxidase ◽

Adenosine Deaminase ◽

Ginkgo Biloba ◽

Critical Role ◽

Kidney Tissue ◽

Ginkgo Biloba Extract ◽

Sprague Dawley ◽

Sprague Dawley Rats

This study was carried out to determine if Ginkgo Biloba Extract (GBE or Egb 761) exerts a beneficial effect against cisplatin-induced renal failure in rats. Sprague Dawley rats were divided into four groups. The first group (control) received orally 1 mL/kg/day of 0.9% saline by an oral carrier vehicle on days 1 to 10. The second group was injected with 7 mg/kg cisplatin intraperitoneally (i.p.) on the fourth day, once only. The third group (vit E=cisplatin) was administered 10 mg/kg/day i.p. vit E on 1 to 10 days with one dose of i.p. cisplatin (7 mg/kg) injection on the fourth day. The fourth group (GBE=cisplatin) was given GBE orally at 100 mg/mL/kg started on the first day up to the tenth day with one dose of cisplatin (7 mg/kg) injection on the fourth day. Cisplatin was found to lead a statistically significant increase in plasma BUN and creatinine levels, as well as urine micro total protein (MTP) levels, leading to acute renal failure (ARF) in rats. Renal xanthine oxidase (XO) activities increased in all groups (statistically significant in cisplatin=GBE-treated rats; P≤0.001). Adenosine deaminase (AD) activities were increased in cisplatin-treated rats, and decreased in cisplatin=GBE-treated (PB≤0.041) and cisplatin=vit E-treated (PB≤0.005) rats, compared to controls. Malondialdehyde (MDA), nitric oxide (NO) levels and myeloperoxidase (MPO) activities were increased in the kidney tissue of cisplatin-treated rats. Vit E improved plasma creatinine and urine MTP levels, together with tissue MDA, NO levels, and MPO activities. But GBE had no statistically significant effect on those parameters. These results indicate that increased XO, AD and MPO activities, as well as MDA and NO levels play a critical role in cisplatin nephrotoxicity. GBE has been shown to protect against cisplatin-induced nephrotoxicity. Toxicology and Industrial Health 2006; 22: 125-130.

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