Oral Magnesium Supplementation Decreases C-reactive Protein Levels in Subjects with Prediabetes and Hypomagnesemia: A Clinical Randomized Double-blind Placebo-controlled Trial

2014 ◽  
Vol 45 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Luis E. Simental-Mendía ◽  
Martha Rodríguez-Morán ◽  
Fernando Guerrero-Romero
Keyword(s):  
Controlled Trial ◽  
C Reactive Protein ◽  
Magnesium Supplementation ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Protein Levels ◽  
Reactive Protein ◽  
Oral Magnesium

Effects of Transdermal and Oral Oestrogen Replacement Therapy on C-Reactive Protein Levels in Postmenopausal Women: A Randomised, Placebo-Controlled Trial

2002 ◽  
Vol 88 (10) ◽  
pp. 605-610 ◽  
Author(s):  
M. S. Post ◽  
C. D. A. Stehouwer ◽  
W. M. van Baal ◽  
V. Mijatovic ◽  
C. G. Schalkwijk ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Day Treatment ◽  
Controlled Trial ◽  
C Reactive Protein ◽  
Double Blind ◽  
Median Percentage ◽  
Protein Levels ◽  
Reactive Protein ◽  
Group Data ◽  
Median Percentage Change

SummaryTo investigate the effect of postmenopausal oral and transdermal hormone therapy on plasma levels of C-reactive protein (CRP), we performed a randomised, double-blind, double-dummy, placebo-controlled, 15-month study. One hundred and fifty-two healthy hysterectomised postmenopausal women received daily either placebo (n = 49), or transdermal 17 β-oestradiol (E2) 50 µg (tE2 group, n = 33), or oral E2 1 mg (oE2 group, n = 37), or oral E2 1 mg combined with gestodene 25 µg (oE2 + G group, n = 33) for thirteen 28-day treatment cycles, followed by four cycles placebo for each group. Data were collected at baseline and in cycles 4, 13 and 17. In cycle 13, CRP was significantly increased in the oE2 group compared to placebo (P = 0.004). The median percentage change from baseline versus placebo was +75% (P <0.001). In cycle 17, significantly lower values were observed in the oE2 group compared to cycle 13 and to the placebo group (-49%, P <0.001). There were no significant changes versus placebo in the other groups. In conclusion, oral E2 significantly increased CRP levels. This change was larger than the increase found during oral E2 + G. Transdermal E2 did not affect CRP levels.

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