Association of serum lipid profile and family history of coronary heart disease among middle aged Lithuanian adults

P94 Background: Selective blood cholesterol screening of children based upon National Cholesterol Education Program (NCEP) guidelines of family history of premature cardiovascular disease (CVD) or parental hypercholesterolemia is inadequate in a population with high prevalence of coronary heart disease (CHD), low levels of cholesterol screening, low socio-economic status (SES) and diminished access to preventive health care. We hypothesize that universal cholesterol screening of pre-pubertal school children may be effective in identifying children and their parents with abnormal lipid levels in this high risk rural population. Fifth grade school children from seven rural Appalachian counties participated in a school based cholesterol screening program. Data on family history of premature CHD, anthropometric and blood pressure measurements, tobacco smoke exposure, dietary history and physical activity levels were collected at the time of screening. Seven hundred and nine 5 th grade students ( mean age 10.8 years) participated in the program. One hundred seventy four (24.5%) were considered presumptively dyslipidemic after non-fasting finger- stick (FS) cholesterol screening. Thirty six percent of these dyslipidemic children had a fasting lipid profile done. Dyslipidemia was confirmed in 37(59%) of these children. FS cholesterol levels were significantly correlated with fasting TC (r=0.80 p < 0.0001). Among confirmed dyslipidemic children, family history was not a good predictor of dyslipidemia (sensitivity 21.6%). Seventy nine parents of dyslipidemic children participated in fasting lipid profile assessment. Fifty two parents (67%) were dyslipidemic, most of them (79%) did not have a family history of premature CHD or hypercholesterolemia. FS cholesterol levels were also correlated with fasting TC of fathers (r=0.46 p=0.01), and mothers (r=0.32 p=0.02). Conclusion: Significant correlation exists between non-fasting FS cholesterol levels of children and subsequent fasting lipid profile of children and their parents. Family history has low sensitivity in predicting children with elevated serum cholesterol concentrations.

Download Full-text

Lp(a) phenotypes, other lipoprotein parameters, and a family history of coronary heart disease in middle-aged males

Clinical Genetics ◽

10.1111/j.1399-0004.1979.tb01014.x ◽

2008 ◽

Vol 16 (5) ◽

pp. 347-352 ◽

Cited By ~ 66

Author(s):

Kåre Berg ◽

Gosta Dahlén ◽

Anne-Lise Bórresen

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Middle Aged ◽

History Of

Download Full-text

AB0631 THE PREVALENCE AND FACTORS ASSOCIATED WITH CORONARY HEART DISEASE IN PATIENTS WITH GOUT

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.1241 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1350.1-1350

Author(s):

E. Markelova ◽

M. Elisеev ◽

E. Ilinykh ◽

S. Glukhova ◽

T. Popkova

Keyword(s):

Coronary Heart Disease ◽

Renal Failure ◽

Uric Acid ◽

Heart Disease ◽

Family History ◽

Serum Creatinine ◽

Lipid Profile ◽

Disease Duration ◽

Factors Associated ◽

History Of

Background:Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.Objectives:The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout.Methods:286 male patients fulfilling Wallace proposed criteria for gout were included: age 51.2 [42.8;59.4] years (ys), disease duration – 6.2 [3.8;12.1] ys. All patients underwent standard clinical examination, screening traditional risk factors (TRF) of CVD, blood chemistry test with estimation of serum uric acid, serum creatinine, C-reactive protein (CRP), as well as lipid profile. Carotid intima-media thickness (cIMT) was measured using a high-resolution B-mode ultrasound machine. CHD included history of angina pectoris and/or myocardial infarction. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).Results:CHD was found in 111 out of the 286 pts (38.8 %). Compared to individuals with CHD, participants without CHD were older (56.7[52.1; 61.1] vs 46.2[40.6; 53.4] ys), had longer duration of gout (9.3[4.7; 15.1] vs 5.6[3.3; 9.7] ys), higher number of joints involved during disease course (8[6; 15] vs 6[4; 10]), duration of smoking (24[10; 40] vs 20[10; 28]), higher serum creatinine level accordingly, (for all p<0.05). The frequency of family history of CHD (63% vs 46.8%), intraosseous tophi (61.3% vs 33.1%), was higher in pts with CHD compared pts without CHD accordingly, (for all p<0.01). Prevalence of arterial hypertension, diabetes mellitus, nephrolithiasis, heart failure and renal failure was greater in pts with CHD than pts without CHD (p<0.001). Gout pts with CHD had a significantly higher cIMT compare to those without CHD - 0.95[0.8;1.08]/0.8[0.7;0.9] accordingly, p<0.001. We didn’t find differences of lipid profile, serum uric acid, and CRP level in gout pts with/without CHD.Abdominal obesity (OR, 5.5; 95% CI, 2.2-13.6), body mass index >30 kg/m2 (OR, 5.8; 95% CI, 1.8-18.5), family history of CHD (OR, 2.7; 95% CI, 1.3-5.4), disease duration of gout more 10 ys (OR, 2.6; 95% CI, 1.3-5.1), age of gout onset < 35 ys (OR, 3.0; 95% CI, 1.5-6.1), intraosseous tophi (OR, 3.1; 95% CI, 1.4-7.0), C-RP (OR, 2.2; 95% CI, 1.1-4.7), renal failure (OR, 18,8; 95% CI, 1.1-312.9), increased the risk for CHD in patients with a gout.Conclusion:The prevalence of CHD was 38.8% among individuals with gout. Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.Disclosure of Interests:None declared.

Download Full-text