scholarly journals AB0631 THE PREVALENCE AND FACTORS ASSOCIATED WITH CORONARY HEART DISEASE IN PATIENTS WITH GOUT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1350.1-1350
Author(s):  
E. Markelova ◽  
M. Elisеev ◽  
E. Ilinykh ◽  
S. Glukhova ◽  
T. Popkova
Keyword(s):  
Coronary Heart Disease ◽  
Renal Failure ◽  
Uric Acid ◽  
Heart Disease ◽  
Family History ◽  
Serum Creatinine ◽  
Lipid Profile ◽  
Disease Duration ◽  
Factors Associated ◽  
History Of

Background:Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.Objectives:The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout.Methods:286 male patients fulfilling Wallace proposed criteria for gout were included: age 51.2 [42.8;59.4] years (ys), disease duration – 6.2 [3.8;12.1] ys. All patients underwent standard clinical examination, screening traditional risk factors (TRF) of CVD, blood chemistry test with estimation of serum uric acid, serum creatinine, C-reactive protein (CRP), as well as lipid profile. Carotid intima-media thickness (cIMT) was measured using a high-resolution B-mode ultrasound machine. CHD included history of angina pectoris and/or myocardial infarction. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).Results:CHD was found in 111 out of the 286 pts (38.8 %). Compared to individuals with CHD, participants without CHD were older (56.7[52.1; 61.1] vs 46.2[40.6; 53.4] ys), had longer duration of gout (9.3[4.7; 15.1] vs 5.6[3.3; 9.7] ys), higher number of joints involved during disease course (8[6; 15] vs 6[4; 10]), duration of smoking (24[10; 40] vs 20[10; 28]), higher serum creatinine level accordingly, (for all p<0.05). The frequency of family history of CHD (63% vs 46.8%), intraosseous tophi (61.3% vs 33.1%), was higher in pts with CHD compared pts without CHD accordingly, (for all p<0.01). Prevalence of arterial hypertension, diabetes mellitus, nephrolithiasis, heart failure and renal failure was greater in pts with CHD than pts without CHD (p<0.001). Gout pts with CHD had a significantly higher cIMT compare to those without CHD - 0.95[0.8;1.08]/0.8[0.7;0.9] accordingly, p<0.001. We didn’t find differences of lipid profile, serum uric acid, and CRP level in gout pts with/without CHD.Abdominal obesity (OR, 5.5; 95% CI, 2.2-13.6), body mass index >30 kg/m2 (OR, 5.8; 95% CI, 1.8-18.5), family history of CHD (OR, 2.7; 95% CI, 1.3-5.4), disease duration of gout more 10 ys (OR, 2.6; 95% CI, 1.3-5.1), age of gout onset < 35 ys (OR, 3.0; 95% CI, 1.5-6.1), intraosseous tophi (OR, 3.1; 95% CI, 1.4-7.0), C-RP (OR, 2.2; 95% CI, 1.1-4.7), renal failure (OR, 18,8; 95% CI, 1.1-312.9), increased the risk for CHD in patients with a gout.Conclusion:The prevalence of CHD was 38.8% among individuals with gout. Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.Disclosure of Interests:None declared.

Association of serum lipid profile and family history of coronary heart disease among middle aged Lithuanian adults

2018 ◽  
Vol 275 ◽  
pp. e215
Author(s):  
S. Kutkiene ◽  
Z. Petrulioniene ◽  
A. Laucevicius ◽  
U. Gargalskaite ◽  
A. Saulyte ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Middle Aged ◽  
History Of

scholarly journals Cholesterol Screening in Children and Family History of Coronary Heart Disease.

Circulation ◽  
2001 ◽  
Vol 103 (suppl_1) ◽  
pp. 1369-1369
Author(s):  
Viktorina N Muratova ◽  
Syed S Islam ◽  
Emily C Spangler ◽  
Ellen W Demerath ◽  
William A Neal
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Lipid Profile ◽  
School Children ◽  
Preventive Health Care ◽  
Blood Cholesterol ◽  
Cholesterol Screening ◽  
Cholesterol Levels ◽  
History Of

P94 Background: Selective blood cholesterol screening of children based upon National Cholesterol Education Program (NCEP) guidelines of family history of premature cardiovascular disease (CVD) or parental hypercholesterolemia is inadequate in a population with high prevalence of coronary heart disease (CHD), low levels of cholesterol screening, low socio-economic status (SES) and diminished access to preventive health care. We hypothesize that universal cholesterol screening of pre-pubertal school children may be effective in identifying children and their parents with abnormal lipid levels in this high risk rural population. Fifth grade school children from seven rural Appalachian counties participated in a school based cholesterol screening program. Data on family history of premature CHD, anthropometric and blood pressure measurements, tobacco smoke exposure, dietary history and physical activity levels were collected at the time of screening. Seven hundred and nine 5 th grade students ( mean age 10.8 years) participated in the program. One hundred seventy four (24.5%) were considered presumptively dyslipidemic after non-fasting finger- stick (FS) cholesterol screening. Thirty six percent of these dyslipidemic children had a fasting lipid profile done. Dyslipidemia was confirmed in 37(59%) of these children. FS cholesterol levels were significantly correlated with fasting TC (r=0.80 p < 0.0001). Among confirmed dyslipidemic children, family history was not a good predictor of dyslipidemia (sensitivity 21.6%). Seventy nine parents of dyslipidemic children participated in fasting lipid profile assessment. Fifty two parents (67%) were dyslipidemic, most of them (79%) did not have a family history of premature CHD or hypercholesterolemia. FS cholesterol levels were also correlated with fasting TC of fathers (r=0.46 p=0.01), and mothers (r=0.32 p=0.02). Conclusion: Significant correlation exists between non-fasting FS cholesterol levels of children and subsequent fasting lipid profile of children and their parents. Family history has low sensitivity in predicting children with elevated serum cholesterol concentrations.

scholarly journals Potential Errors Resulting from Sex and Age Difference in Assessing Family History of Coronary Heart Disease

2004 ◽  
Vol 14 (2) ◽  
pp. 51-56 ◽  
Author(s):  
Tomohiro Saito ◽  
Toshihito Furukawa ◽  
Seiichiro Nanri ◽  
Ikuo Saito
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Age Difference ◽  
History Of

scholarly journals Is a family history of coronary heart disease an independent coronary risk factor?

Heart ◽  
1985 ◽  
Vol 53 (4) ◽  
pp. 378-381 ◽  
Author(s):  
R M Conroy ◽  
R Mulcahy ◽  
N Hickey ◽  
L Daly
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Family History ◽  
Coronary Risk Factor ◽  
Coronary Risk ◽  
History Of

scholarly journals Faktor Risiko Terjadinya Penyakit Jantung Koroner pada Pasien di Unit Rawat Jalan Rumah Sakit Panti Rapih Yogyakarta

2020 ◽  
Vol 1 (1) ◽  
pp. 21-30
Author(s):  
Deviana Widayanti ◽  
Chatarina Setya Widyastuti
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Disease Risk ◽  
Sampling Technique ◽  
Excess Body Weight ◽  
History Of ◽  
Lack Of Exercise

Background: Coronary Heart Disease (CHD) Is a condition when the arteries that supply blood to the heart wall experience hardening and narrowing. It is estimated that 30% of coronary heart disease causes death worldwide. Objective: This study aims to determine the risk factors for CHD in Panti Rapih Hospital. Methods: This descriptive study aims to determine the risk factors for CHD in outpatients at Panti Rapih Hospital. The population is patients who have been diagnosed with coronary heart disease and the sample was taken by 50 respondents with non-random accidental sampling technique. This research take the data use questionnaire and make univariat analysis. Results: Risk factors for CHD are a number of factors that cannot be changed: family history of 42%, age = 40 years 95% in men and 95% age = 65 years in women. Factors that can be changed are: Smoking 78%, history of hypertension 68%, history of diabetes mellitus 28%, dyslipidemic 90%, excess body weight42% and lack of exercise 38%. Conclusion: Risk factors for CHD that cannot be changed: family history of 42%, age = 40 years 95% in men and 95% age = 65 years in women. Factors that can be changed are: Smoking 78%, history of hypertension 68%, history of diabetes mellitus 28%, dyslipidemic 90%, excess body weight 42% and lack of exercise 38%.     Keywords: coronary heart disease, risk factors

Abstract MP26: Silent Small-vessel Cerebrovascular Disease In Individuals With A Family History Of Coronary Heart Disease: The Atherosclerosis Risk In Communities (ARIC) Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Michelle C Johansen ◽  
Paul A Nyquist ◽  
Kevin Sullivan ◽  
Myriam Fornage ◽  
Rebecca F Gottesman ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Cerebrovascular Disease ◽  
Brain Magnetic Resonance Imaging ◽  
Cerebral Microbleeds ◽  
Lacunar Infarct ◽  
White Matter Hyperintensity ◽  
Linear Regression Models ◽  
History Of

Background: It is established that a family history of coronary heart disease (FHCHD) is associated with coronary atherosclerosis in healthy first-degree relatives, but the extent to which FHCHD is associated with silent cerebrovascular disease (cSVD) is unknown. We hypothesized a higher prevalence of cSVD in healthy persons with FHCHD, independent of traditional risk factors, compared to those without FHCHD. Methods: ARIC is a community-based cohort study with self-reported family history data and brain magnetic resonance imaging (visit 5; 2011-13). The association between binary markers of cSVD (lacunar infarcts and/or cerebral microbleeds), or log-transformed white matter hyperintensity volume (WMH), and FHCHD (parent and/or sibling), or number of relatives was examined using separate adjusted multivariable logistic or linear regression models respectively. Sensitivity analysis (N=183) excluded prevalent CHD. Race interaction terms were included. Results: Of 1828 participants (76±5yo, 60% female, 28% black), 787 had FHCHD (699 parental, 209 sibling FHCHD). There were increased adjusted odds of lacunar infarct among those with parental FHCHD (Table). An increased odds of cerebral microbleeds were seen among those with sibling history but not parental. Effect estimates were similar when excluding those with prevalent CHD (Table). Greater number of siblings affected was associated with higher odds of lacunar infarct (OR 1.35, CI 1.04-1.74), lobar (OR 1.53, CI 1.12-2.09) and subcortical microbleeds (OR 1.30, CI 1.01-1.66). Odds of a lacunar infarct being present were higher among blacks (p-interaction 0.04) with paternal FHCHD (OR 2.20, CI 1.35-3.58) compared to whites (OR 1.17, CI 0.87-1.56). Neither FHCHD nor number of affected relatives was associated with WMH. Conclusions: Our results suggest that some cSVD manifestations are associated with FHCHD, potentially representing shared mechanisms in different vascular beds, and perhaps a genetic propensity for vascular disease.

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