Impaired HDL cholesterol efflux capacity in subjects with metabolically- but not genetically- driven non-alcoholic fatty liver disease (NAFLD)

2020 ◽  
Vol 315 ◽  
pp. e155
Author(s):  
A. Di Costanzo ◽  
A. Ronca ◽  
L. D'Erasmo ◽  
M. Manfredini ◽  
F. Baratta ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cholesterol Efflux ◽  
Hdl Cholesterol ◽  
Alcoholic Fatty Liver ◽  
Cholesterol Efflux Capacity ◽  
Alcoholic Fatty Liver Disease

scholarly journals NON-ALCOHOLIC FATTY LIVER DISEASE AND HYPERTENSION: CLINICAL VARIABILITY OF COMORBIDITY

2020 ◽  
Vol 7 (3) ◽  
Author(s):  
Anastasiia Rozhdestvenska ◽  
Oleg Babak ◽  
Natalia Zhelezniakova
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Clinical Manifestation ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Trigger Factor ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Significant Difference ◽  
Alcoholic Fatty Liver Disease

Introduction. Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases; and considerable attention is paid to the comorbidity of NAFLD with hypertension (HT), which affects around one-third of the world's population. The combination of NAFLD with hypertension has been suggested to have a mutual potentiating effect, and hypertension affects the severity of NAFLD. The purpose: to study the features of the clinical manifestation of NAFLD in patients with hypertension. Materials and methods. The study included 115 patients with NAFLD at the stage of nonalcoholic steatohepatitis. The main group consisted of 63 patients with NAFLD and HT, the comparison group included 52 patients with isolated NAFLD, and the control group was composed of 20 healthy volunteers. The patients underwent anthropometric measurements, evaluation of biochemical markers of liver functional activity, lipid profile and carbohydrate metabolism changes, C-reactive protein (CRP) levels. Results. A significant increase in the proportion of patients with active complaints in the group of patients with NAFLD with HT (subjective signs of liver damage, manifestations of dyspeptic and asthenic syndrome) was detected. Significant differences were found in almost all anthropometric indicators in both groups of patients with NAFLD in comparison with the control group. The level of CRP had significant differences and was 7.90 mg/l (95% CI = 7.96-8.75 mg/l), 6.55 mg/l (95% CI = 6.47-7.57 mg/l) and 2.07 (95% CI = 1.83-2.85 mg/l) in patients with NAFLD and HT, isolated NAFLD and the control group, respectively (p <0.001). Fasting glucose levels were significantly higher in both groups of examined patients with NAFLD compared with controls. Significant differences were found in the levels of total cholesterol, VLDL cholesterol, HDL cholesterol and atherogenic factor in patients with NAFLD depending on concomitant HT. There was no significant difference between LDL cholesterol and triglycerides in the two groups of patients with NAFLD. Conclusions. Based on the obtained data, it can be stated that GC in patients with NAFLD determines important deviations in the clinical manifestation of the disease and can be considered as a trigger factor for the progression of NAFLD.

scholarly journals Hubungan Kadar Trigliserida dan Kolesterol-HDL Terhadap Kadar Alanine Aminotransferase pada Pasien Non Alcoholic Fatty Liver Disease

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Bayu Gemilang ◽  
Yanwirasti Yanwirasti ◽  
Saptino Miro
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Alanine Aminotransferase ◽  
Fatty Liver Disease ◽  
Pearson Correlation ◽  
Hdl Cholesterol ◽  
Alcoholic Fatty Liver ◽  
Clinical Appearance ◽  
The Metabolic Syndrome ◽  
Alcoholic Fatty Liver Disease

AbstrakTrigliserida dan Kolesterol HDL (c-HDL) merupakan beberapa dari komponen Sindroma Metabolik (SM). SM dipercaya merupakan faktor utama penyebab Non Alcoholic Fatty Liver Disease (NAFLD). NAFLD merupakan penyakit hati kronik yang nantinya dapat menyebabkan fibrosis sel-sel hepar dan juga keganasan. NAFLD tidak menunjukkan manifestasi klinis yang khas, sehingga diperlukan pemeriksaan penunjang seperti pemeriksaan enzim hati untuk menegakkan diagnosis. Alanine Aminotransferase (ALT) menjadi pilihan sebagai marker pada penyakit NAFLD. Tujuan penelitian ini adalah menentukan hubungan antara trigliserida dan c-HDL dengan ALT pada penderita NAFLD. Ini merupakan penelitian analitik deskriptif dengan desain retrospektif menggunakan data pasien NAFLD di instalasi rekam medik RSUP dr.M.Djamil Padang. Sampel penelitian ini adalah 51 pasien NAFLD. Hasil penelitian didapatkan dari uji korelasi pearson terdapat derajat hubungan yang kuat (r=0,512) dan hubungan yang bermakna (p<0,001) antara kadar trigliserida dengan kadar ALT serum dan derajat hubungan yang sedang (r=0,26) dan hubungan yang tidak bermakna (p=0,065) antara c-HDL dengan ALT serum. Kesimpulan penelitian ini adalah kadar ALT berhubungan dengan kadar trigliserida pada penderita NAFLD, namun tidak dengan c-HDLKata kunci: NAFLD, trigliserida, HDL, ALT, sindroma metabolik AbstractTriglyceride and HDL Cholesterol (HDL-C) are some of the Metabolic Syndrome (MS) components. MS is believed as the main factor for the Non Alcoholic Fatty Liver Disease (NAFLD). NAFLD is a chronic liver disease, which later can cause hepatocyte fibrosis and also malignancy. NAFLD does not show a typical clinical appearance, so it is important to do workups such as liver enzyme test to make the diagnosis. Alanine Aminotransferase (ALT) is considered as the marker of NAFLD.The objective of this study was to determine the relationship between triglycerides and HDL-C to ALT level in NAFLD patients.This  was a descriptive analytical study with retrospective design using data of NAFLD patients in the hospital medical record installation of RSUP Dr. M. Djamil Padang. The sample in this study were 51 NAFLD patients. The results obtained from Pearson correlation test was  a strong correlation (r=0,512) and significant (p<0,001) between triglyceride and ALT level, and a moderate correlation (r=0,26) and insignificant (p=0,065) between HDL-C and ALT level. The conclusion is triglyceride level correlated with ALT level in patient with NAFLD.Keywords: NAFLD, triglyceride, HDL, ALT, metabolic syndromes

scholarly journals ENDOTHELIAL LIPASE AS NEW DIAGNOSTIC MARKER OF NON-ALCOHOLIC FATTY LIVER DISEASE IN HYPERTENSIVE SUBJECTS (review)

2018 ◽  
Vol 5 (2) ◽  
pp. 57-63
Author(s):  
A. Bashkirova
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diagnostic Marker ◽  
Hdl Cholesterol ◽  
Endothelial Lipase ◽  
Alcoholic Fatty Liver ◽  
Leading Role ◽  
Negative Factors ◽  
Alcoholic Fatty Liver Disease

ENDOTHELIAL LIPASE AS NEW DIAGNOSTIC MARKER OF NON-ALCOHOLIC FATTY LIVER DISEASE IN HYPERTENSIVE SUBJECTS (review)Bashkirova A.DNon-alcoholic fatty liver disease  (NAFLD) and hypertension are among the most common diseases in the world. One of the negative factors  contributing to the formation of cardiovascular risk in patients with NAFLD affected with hypertension is the low level of HDL cholesterol in which metabolism endothelial lipase (EL) plays a leading role. Therefore, it is very relevant and expedient to study the various aspects of the use of EL to diagnose NAFLD and determe treatment strategy in patients with NAFLD and hypertension.Key words: non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, hypertension, endothelial lipase, lipid metabolism, overweight. ЕНДОТЕЛІАЛЬНА ЛІПАЗА ЯК НОВИЙ ДІАГНОСТИЧНИЙ МАРКЕР НЕАЛКОГОЛЬНИЙ ЖИРОВОЇ ХВОРОБИ ПЕЧІНКИ (НАЖХП) У ОСІБ З ГІПЕРТЕНЗІЄЮ (огляд)Башкірова А.Д.НАЖХП і гіпертонічна хвороба є одними з найпоширеніших хвороб у світі. Одним з несприятливих факторів, що сприяють формуванню кардіоваскулярного ризику у пацієнтів з НАЖБП на тлі гіпертонічної хвороби, є низький рівень холестерину ЛПВЩ, в метаболізмі якого грає провідну роль активність ендотеліальної ліпази. Тому досить актуальним і доцільним є вивчення різних аспектів використання ЕЛ для діагностики НАЖБП з подальшим визначенням лікувальної тактики у хворих НАЖХП на тлі ГХ.Ключові слова: неалкогольна жирова хвороба печінки, неалкогольний стеатогепатит, гіпертонічна хвороба, ендотеліальналіпаза, ліпіднийобмін, надлишковамасатіла . ЭНДОТЕЛИАЛЬНАЯ ЛИПАЗА КАК НОВЫЙ ДИАГНОСТИЧЕСКИЙ МАРКЕР НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ (НАЖБП)У ЛИЦ С ГИПЕРТЕНЗИЕЙ (обзор)Башкирова А.Д.НАЖБП и гипертоническая болезнь являются одними из самых распространенных болезней в мире. Одним из неблагоприятных факторов, способствующих формированию кардиоваскулярного риска у пациентов с НАЖБП на фоне гипертонической болезни, является низкий уровень холестерина ЛПВП, в метаболизме которого играет ведущую роль активность эндотелиальной липазы. Поэтому весьма актуальным и целесообразным является изучение различных аспектов использования ЭЛ для диагностики НАЖБП с последующим определением лечебной тактики у больных НАЖБП на фоне ГБ. Ключевые слова: неалкогольная жировая болезнь печени, неалкогольный стеатогепатит, гипертоническая болезнь, эндотелиальная липаза, липидный обмен, избыточная масса тела.

scholarly journals HDL-Mediated Cholesterol Efflux and Plasma Loading Capacities Are Altered in Subjects with Metabolically- but Not Genetically Driven Non-Alcoholic Fatty Liver Disease (NAFLD)

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 625
Author(s):  
Alessia Di Costanzo ◽  
Annalisa Ronca ◽  
Laura D’Erasmo ◽  
Matteo Manfredini ◽  
Francesco Baratta ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cholesterol Efflux ◽  
Ex Vivo ◽  
Density Lipoprotein ◽  
Alcoholic Fatty Liver ◽  
Genotype Group ◽  
Cellular Models ◽  
Alcoholic Fatty Liver Disease

Background. Non-alcoholic fatty liver disease (NAFLD) increases the risk of atherosclerosis but this risk may differ between metabolically- vs. genetically-driven NAFLD. High-density lipoprotein (HDL)-mediated cholesterol efflux (CEC) and plasma loading capacity (CLC) are key factors in atherogenesis. Aims. To test whether CEC and CLC differ between metabolically- vs. genetically-determined NAFLD. Methods: CEC and CLC were measured in 19 patients with metabolic NAFLD and wild-type PNPLA3 genotype (Group M), 10 patients with genetic NAFLD carrying M148M PNPLA3 genotype (Group G), and 10 controls PNPLA3 wild-types and without NAFLD. CEC and CLC were measured ex vivo by isotopic and fluorimetric techniques using cellular models. Results: Compared with Group G, Group M showed reduced total CEC (−18.6%; p < 0.001) as well as that mediated by cholesterol transporters (−25.3% ABCA1; −16.3% ABCG1; −14.8% aqueous diffusion; all p < 0.04). No difference in CEC was found between Group G and controls. The presence of metabolic syndrome further impaired ABCG1-mediated CEC in Group M. Group M had higher plasma-induced CLC than Group G and controls (p < 0.001). Conclusions: Metabolically-, but not genetically-, driven NAFLD associates with dysfunctional HDL-meditated CEC and abnormal CLC. These data suggest that the mechanisms of anti-atherogenic protection in metabolic NAFLD are impaired.

Abstract P380: Obesity and Non-Alcoholic Fatty Liver Disease in Children

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Stephanie J Frisbee ◽  
Jefferson C Frisbee ◽  
Alan M Ducatman
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Age Groups ◽  
Hdl Cholesterol ◽  
Class Action ◽  
Cvd Risk ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

The increasing prevalence of childhood obesity has been well documented and is predictive of an increased severity in obesity-related CVD risk factors and metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD). This study determined the association between obesity and risk for altered liver function and NAFLD in 12,476 children (≤18 years) enrolled in the C8 Health Project, which resulted from pretrial settlement of a class action lawsuit pursuant to contamination of the drinking water supply (Frisbee et al, 2009). In this population, 48% were female, median age and BMI percentile were 11.6 years and 76, respectively, with 39.8% classified as overweight (OWT) or obese (OB). Seven serum biomarkers of liver function (ALT, AST, total (bili-t) & direct (bili-d) bilirubin, alkaline phosphatase (AlkPhos), GGT, & lactate dehydrogenase (LDH)) were available for 10,543 children. Based on prior categorization (Schwimmer et al, 2005), ALT or AST≥40IU/L were considered indicative of NAFLD. In linear regression adjusted for age, gender, SES (socio-economic status) and non-HDL cholesterol, BMI (z score) was significantly associated with all liver biomarkers (b coefficient±SE/adj R-square): ALT (1.6±0.1/6.6%); AST (-0.3±0.1/17.8%); bili-d (-0.002±0.0004/16.8%); bili-t (-0.01±0.002/9.4%); AlkPhos (-4.3±0.8/27.7%); GGT (1.0±0.1/18.0%); LDH (2.4±0.3/44.6%). Results for logistic regression assessing for NAFLD risk based on OWT or OB are shown Table 1. Overall, there was a stronger association between NAFLD risk with increasing BMI for ALT compared to AST (2-6 fold compared to insignificant risk). This pattern was similar for girls and boys. Interestingly, age stratified analysis revealed that obesity was slightly protective from AST-defined NAFLD in younger age groups, but this reversed in older ages. OWT and OB were associated with increased ALT-defined NAFLD, particularly in older ages. These results suggest a complex, non-linear and age-dependent association between obesity and NAFLD in children. Obesity and Risk for Non-Alcoholic Fatty Liver Disease OR (95%CI) for ALT >=40 IU/L OR (95% CI) for AST >=40 IU/L Total Population OWT: 2.0 (1.3-3.0)/OB: 5.9 (4.2-8.1) NSS Gender Stratified Female OWT: 2.2 (1.2-4.3)/OB: 4.7 (2.7-8.1) NSS Male OWT: 1.9 (1.1-3.3)/OB: 6.6 (4.4-10.0) NSS Age Group Stratified < 5 Yrs NSS OWT: 0.2 (0.1-0.7)/OB: 0.3 (0.1-0.5) 5-9.9 Yrs OWT: NSS/OB: 3.6 (1.3-9.9) OWT: NSS/OB: 0.5 (0.3-0.9) 10-14.9 Yrs OWT: NSS/OB: 7.0 (4.3-11.1) OWT: NSS/OB: 2.4 (1.4-4.1) 15-17.9 Yrs OWT: 2.2 (1.2-4.0)/OB: 5.3 (3.2-8.6) NSS Models adjusted for age (except age stratified), gender (except gender stratified), SES,&non-HDL c

Cholesteryl Ester Transfer Protein Variant (RS1800777) with Liver Histology in Non-Alcoholic Fatty Liver Disease Patients

2018 ◽  
Vol 73 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Rocio Aller ◽  
Olatz Izaola ◽  
David Primo ◽  
Daniel de Luis
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Alcoholic Fatty Liver ◽  
Transfer Protein ◽  
Alcoholic Fatty Liver Disease

Introduction and Aims: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases ranging from simple steatosis without inflammation or fibrosis to nonalcoholic steatohepatitis and in the Western countries has become one of the most prevalent chronic liver diseases related to metabolic and lipid alterations. Cholesteryl ester transfer protein (CETP) participates in high density lipoprotein (HDL)-cholesterol metabolism. The aim of our study was to investigate the influence of polymorphism (rs1800777) of CETP gene on liver histological changes, biochemical parameters, and serum adipokines levels in patients with NAFLD. Material and Methods: A population of 90 patients with NAFLD was recruited in a cross-sectional study. A biochemical analysis (glucose, c-reactive protein, insulin, homeostasis model assessment-insulin resistance, total cholesterol, low density lipoprotein (LDL)-cholesterol, HDL-cholesterol, triglycerides blood, and adipokines (leptin, adiponectin, and resistin) was realized. Genotype of polymorphism (rs1800777) of CETP gene was studied. Results: Eighty-three patients (92.2%) had the genotype GG (wild type group) and 7 patients (7.8%) had the genotype GA (n = 7) or AA (n = 0; mutant type group). Patients with A allele show significant decrease in liver biochemistry parameters – Alanine amino transferase (delta 10.1 ± 9.9 UI/L; p = 0.01), aspartate aminotransferase activity (delta 13.3 ± 9.5 UI/L; p = 0.02), and gammaglutamine transferase levels (delta 39 ± 30.1 UI/L; p = 0.01). Logistic regression analysis indicated that subjects with A-allele carriers were associated with a decreased risk of lobulillar inflammation (OR 0.18, 95% CI 0.04–0.95, p = 0.04) and a decreased risk of steatosis (OR 0.13, 95% CI 0.02–0.89, p = 0.04). Conclusions: A variant of the polymorphism rs1800777 of CETP gene is independently associated with the presence of steatosis and lobulillar inflammation in subjects with proven biopsy NAFLD.

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

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