Comprehensive understanding of multiple actions of anticancer drug tamoxifen in isolated mitochondria

2021 ◽  
pp. 148520
Author(s):  
Yufu Unten ◽  
Masatoshi Murai ◽  
Tomoki Koshitaka ◽  
Kotaro Kitao ◽  
Osamu Shirai ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Comprehensive Understanding ◽  
Isolated Mitochondria

Properties of Isolated Mitochondria of Agaricus Bisporus: Their Relationship to Dormancy and the Germination of Spores

1973 ◽  
Vol 31 ◽  
pp. 458-459
Author(s):  
K. S. McCarty ◽  
R. F. Weave ◽  
L. Kemper ◽  
F. S. Vogel
Keyword(s):  
Mitochondrial Dna ◽  
Ethidium Bromide ◽  
Microscopic Examination ◽  
Agaricus Bisporus ◽  
Osmotic Shock ◽  
Electron Microscopic Examination ◽  
Electron Microscopic ◽  
Isolated Mitochondria ◽  
Dna Strands ◽  
Cytoplasmic Ribosomes

During the prodromal stages of sporulation in the Basidiomycete, Agaricus bisporus, mitochondria accumulate in the basidial cells, zygotes, in the gill tissues prior to entry of these mitochondria, together with two haploid nuclei and cytoplasmic ribosomes, into the exospores. The mitochondria contain prominent loci of DNA [Fig. 1]. A modified Kleinschmidt spread technique1 has been used to evaluate the DNA strands from purified whole mitochondria released by osmotic shock, mitochondrial DNA purified on CsCl gradients [density = 1.698 gms/cc], and DNA purified on ethidium bromide CsCl gradients. The DNA appeared as linear strands up to 25 u in length and circular forms 2.2-5.2 u in circumference. In specimens prepared by osmotic shock, many strands of DNA are apparently attached to membrane fragments [Fig. 2]. When mitochondria were ruptured in hypotonic sucrose and then fixed in glutaraldehyde, the ribosomes were released for electron microscopic examination.

Anticancer drug discovery from filamentous fungi

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
NH Oberlies ◽  
A Sy ◽  
TN Graf ◽  
DJ Kroll ◽  
Y Nakanishi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Filamentous Fungi ◽  
Anticancer Drug ◽  
Anticancer Drug Discovery

Development of Taxol® as an anticancer drug

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DGI Kingston
Keyword(s):  
Anticancer Drug

The Changing Patterns of North Korea’s International Film Co-Productions Since the 1980s: A Global Value Chain Approach

2020 ◽  
pp. 83-108
Author(s):  
Moon Hwy-Chang ◽  
Wenyang Yin
Keyword(s):  
Value Chain ◽  
North Korea ◽  
Film Industry ◽  
International Standards ◽  
The Political ◽  
Global Value Chain ◽  
Comprehensive Understanding ◽  
Changing Patterns ◽  
Film Productions

Although North Korea is one of the most closed countries in the world, it has long been pursuing international cooperation with other countries in order to upgrade the quality of its film industry to international standards. Preceding studies on this topic have mainly focused on the political influences behind filmmaking in general and very few studies have exclusively dealt with North Korea’s international co-productions. In this respect, in order to develop a comprehensive understanding of the internalization strategy of North Korea’s film productions, this paper uses the global value chain as a framework for analysis. This approach helps understand the internationalization pattern of each value chain activity of film co-productions in terms of the film location and the methods for collaborating with foreign partners. By dividing the evolution of North Korea’s international co-productions into three periods since the 1980s, this paper finds that although North Korea has shown mixed results with different aspects of the film value chain, it has generally improved its internationalization over the three periods. This paper further provides strategic directions for North Korea by learning some of the successful Chinese experiences in the film sector regarding collaboration with foreign partners—to foster a win-win situation for all involved parties.

Taʾwīl and the Meaning of the Text in the Arabic Language: An Introduction to Understanding the Qur'an

2010 ◽  
Vol 12 (1-2) ◽  
pp. 337-314
Author(s):  
ʿAbd Allāh Muḥammad al-Shāmī
Keyword(s):  
Figurative Language ◽  
Arabic Language ◽  
Literary Text ◽  
Arabic Text ◽  
Comprehensive Understanding ◽  
Original Meaning ◽  
High Literature

The question of clarifying the meaning of a given Arabic text is a subtle one, especially as high literature texts can often be read in more than one way. Arabic is rich in figurative language and this can lead to variety in meaning, sometimes in ways that either adhere closely or diverge far from the ‘original’ meaning. In order to understand a fine literary text in Arabic, one must have a comprehensive understanding of the issue of taʾwīl, and the concept that multiplicity of meaning does not necessarily lead to contradiction. This article surveys the opinions of various literary critics and scholars of balāgha on this issue with a brief discussion of the concepts of tafsīr and sharḥ, which sometimes overlap with taʾwīl.

POLIGAMI DALAM PERSPEKTIF AL-QUR’AN

2016 ◽  
Vol 1 (2) ◽  
pp. 35-50
Author(s):  
Makrum Makrum
Keyword(s):  
Qualitative Research ◽  
Islamic Law ◽  
Qualitative Approach ◽  
Comprehensive Understanding ◽  
Research Results ◽  
Library Research ◽  
Difference Of Opinion ◽  
Controversial Problem ◽  
The Difference ◽  
Interpretation Method

This paper is discusion the polygamy is still a controversial problem, although much discussed and examined. The difference of opinion among scholars make this problem continues to potentially raises the agree and disagree. Even though it has been regulated in Act Number 1 of 1974 concerning marriage and the compilation of Islamic law (KHI), this does not necessarily make the problem of polygamy is complete. Not a few perpetrators of polygamy choose married under the hand or by sirri. This research uses qualitative approach by implementing thematic interpretation method (maudhu'i) to obtain a comprehensive understanding about polygamy in the Qur'an. The Data obtained through the study of a library research by sharing the data that comes from the various verse of the Qur'an, hadith, book fiqh, research results, books and the news in various media outlets in order to complete the interpretation of the verses of polygamy. Based on the results of this research it is known that the verses of the Qur'an gives a very tight restrictions for those who want to in polygamy. Justice that the conditions of polygamy is not only were quantitative but also qualitative research. In the context of historical-socio, the command of polygamy is intended as a form of the solution to avoid injustice to orphans women. Even if polygamy still want to do, should the husband marrying the widows who have lighten the orphan.

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