Transcription factors in glioblastoma – Molecular pathogenesis and clinical implications

2022 ◽  
Vol 1877 (1) ◽  
pp. 188667
Author(s):  
Kostas A. Papavassiliou ◽  
Athanasios G. Papavassiliou
Keyword(s):  
Transcription Factors ◽  
Molecular Pathogenesis ◽  
Clinical Implications

scholarly journals Megakaryopoiesis and Platelet Biology: Roles of Transcription Factors and Emerging Clinical Implications

2021 ◽  
Vol 22 (17) ◽  
pp. 9615
Author(s):  
Ji-Yoon Noh
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Transcription Factors ◽  
Blood Cells ◽  
Thrombus Formation ◽  
Critical Role ◽  
Clinical Implications ◽  
Disease Development ◽  
Hematopoietic Stem

Platelets play a critical role in hemostasis and thrombus formation. Platelets are small, anucleate, and short-lived blood cells that are produced by the large, polyploid, and hematopoietic stem cell (HSC)-derived megakaryocytes in bone marrow. Approximately 3000 platelets are released from one megakaryocyte, and thus, it is important to understand the physiologically relevant mechanism of development of mature megakaryocytes. Many genes, including several key transcription factors, have been shown to be crucial for platelet biogenesis. Mutations in these genes can perturb megakaryopoiesis or thrombopoiesis, resulting in thrombocytopenia. Metabolic changes owing to inflammation, ageing, or diseases such as cancer, in which platelets play crucial roles in disease development, can also affect platelet biogenesis. In this review, I describe the characteristics of platelets and megakaryocytes in terms of their differentiation processes. The role of several critical transcription factors have been discussed to better understand the changes in platelet biogenesis that occur during disease or ageing.

Molecular Pathogenesis of Mantle Cell Lymphoma: New Perspectives and Challenges With Clinical Implications

2011 ◽  
Vol 48 (3) ◽  
pp. 155-165 ◽  
Author(s):  
Alba Navarro ◽  
Cristina Royo ◽  
Luis Hernández ◽  
Pedro Jares ◽  
Elías Campo
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Molecular Pathogenesis ◽  
Clinical Implications ◽  
Mantle Cell

scholarly journals The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Makoto Meguro ◽  
Toru Mizuguchi ◽  
Masaki Kawamoto ◽  
Koichi Hirata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Pathogenesis ◽  
Clinical Implications

Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications

2001 ◽  
Vol 10 (1-2) ◽  
pp. 1-23 ◽  
Author(s):  
Conor J Magee ◽  
William Greenhalf ◽  
Nathan Howes ◽  
Paula Ghaneh ◽  
John P Neoptolemos
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Molecular Pathogenesis ◽  
Ductal Adenocarcinoma ◽  
Clinical Implications

scholarly journals Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0144561 ◽  
Author(s):  
Tohru Ikuta ◽  
Hassan Sellak ◽  
Nadine Odo ◽  
Adekunle D. Adekile ◽  
Karin M. L. Gaensler
Keyword(s):  
Nitric Oxide ◽  
Transcription Factors ◽  
Clinical Implications ◽  
Cgmp Signaling ◽  
Novel Target

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

Perceptions of Stuttering of Different Age Groups

2019 ◽  
Vol 4 (6) ◽  
pp. 1311-1315
Author(s):  
Sergey M. Kondrashov ◽  
John A. Tetnowski
Keyword(s):  
Age Groups ◽  
School Age Children ◽  
Clinical Implications ◽  
School Age ◽  
Fourth Edition ◽  
Self Perception ◽  
Behavioral Measures ◽  
Self Rating ◽  
Comparison Results ◽  
Subject Pool

Purpose The purpose of this study was to assess the perceptions of stuttering of school-age children who stutter and those of adults who stutter through the use of the same tools that could be commonly used by clinicians. Method Twenty-three participants across various ages and stuttering severity were administered both the Stuttering Severity Instrument–Fourth Edition (SSI-4; Riley, 2009 ) and the Wright & Ayre Stuttering Self-Rating Profile ( Wright & Ayre, 2000 ). Comparisons were made between severity of behavioral measures of stuttering made by the SSI-4 and by age (child/adult). Results Significant differences were obtained for the age comparison but not for the severity comparison. Results are explained in terms of the correlation between severity equivalents of the SSI-4 and the Wright & Ayre Stuttering Self-Rating Profile scores, with clinical implications justifying multi-aspect assessment. Conclusions Clinical implications indicate that self-perception and impact of stuttering must not be assumed and should be evaluated for individual participants. Research implications include further study with a larger subject pool and various levels of stuttering severity.

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