Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells

2008 ◽  
Vol 371 (1) ◽  
pp. 172-176 ◽  
Author(s):  
Daisuke Umeda ◽  
Satomi Yano ◽  
Koji Yamada ◽  
Hirofumi Tachibana
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Laminin Receptor ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells ◽  
Myosin Phosphatase ◽  
Physiological Concentration ◽  
Phosphatase Activation

Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells

2018 ◽  
Vol 77 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Anjali M. Prabhat ◽  
M. Lakshmi Kuppusamy ◽  
Balázs Bognár ◽  
Tamás Kálai ◽  
Kálmán Hideg ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Abstract 2177: Rutin enhances the antiproliferative effect of 5-FU and oxaliplatin in colon cancer cells

2016 ◽  
Author(s):  
Farnoud Nasiri ◽  
Gorkem Kismali ◽  
Merve Alpay ◽  
Funda Kosova ◽  
Dilek Ulker Cakir ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells

Dorycnium pentaphyllum Extract Has Antiproliferative Effect on Human Cervix and Colon Cancer Cells

2019 ◽  
Vol 72 (3) ◽  
pp. 504-512 ◽  
Author(s):  
Selim Demir ◽  
Serap Ozer Yaman ◽  
Sila Ozlem Sener ◽  
Elif Ayazoglu Demir ◽  
Rezzan Aliyazicioglu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells ◽  
Human Cervix

First Report on Cydonia oblonga Miller Anticancer Potential: Differential Antiproliferative Effect against Human Kidney and Colon Cancer Cells

2010 ◽  
Vol 58 (6) ◽  
pp. 3366-3370 ◽  
Author(s):  
Márcia Carvalho ◽  
Branca M. Silva ◽  
Renata Silva ◽  
Patrícia Valentão ◽  
Paula B. Andrade ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Kidney ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells ◽  
Cydonia Oblonga ◽  
First Report

scholarly journals Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells

2013 ◽  
Vol 175-176 ◽  
pp. 50-56 ◽  
Author(s):  
S. Molina ◽  
M.I. Moran-Valero ◽  
D. Martin ◽  
L. Vázquez ◽  
T. Vargas ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Butyric Acid ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells

scholarly journals High Glucose Modulates Antiproliferative Effect and Cytotoxicity of 5-Fluorouracil in Human Colon Cancer Cells

2014 ◽  
Vol 33 (2) ◽  
pp. 64-72 ◽  
Author(s):  
Yi-Shing Ma ◽  
I-Ping Yang ◽  
Hsiang-Lin Tsai ◽  
Ching-Wen Huang ◽  
Suh-Hang Hank Juo ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
High Glucose ◽  
Human Colon ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Antiproliferative effect of carotenoids on human colon cancer cells without conversion to retinoic acid

1998 ◽  
Vol 32 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Nobuhito Onogi ◽  
Masataka Okuno ◽  
Rie Matsushima‐Nishiwaki ◽  
Yasushi Fukutomi ◽  
Hisataka Moriwaki ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Human Colon ◽  
Antiproliferative Effect ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways

2021 ◽  
Author(s):  
Feng Ding ◽  
Su Yang
Keyword(s):  
Colon Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Nude Mice ◽  
The Body ◽  
Antiproliferative Effect ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Colon Cancer Cells ◽  
Underlying Mechanisms

The present study evaluated whether EGCG effectively attenuates tumor growth in colon cancer cells and in the xenografts of nude mice and to investigated the underlying mechanisms by focusing on the Shh and PI3K pathways. Three kinds of colon cancer cells and BALB/c nude mice were used to evaluate the antiproliferative effect of EGCG.The results showed that EGCG exhibited an antiproliferative effect against colon cancer cells in a dose-dependent manner with low toxicity against normal colon epithelial cells. Administration of EGCG caused significant apoptosis and inhibited the migration and invasion of colon cancer cells. The toxic effect of EGCG was accompanied by downregulation of the Shh and PI3K/Akt pathways. In addition, EGCG reduced tumor weight without affecting the body weight of nude mice and inhibited the activation of the Shh and PI3K/Akt pathways in tumor tissue. Purmorphamine (Shh agonist) or IGF-1 (PI3K agonist) partly abolished the effect of EGCG on cell proliferation, migration and apoptosis. Cyclopamine (Shh inhibitor) and LY294002 (PI3K inhibitor) showed the similar toxic effects as EGCG on colon cancer cells. In conclusion, EGCG inhibited colon tumor growth via downregulation of the Shh and PI3K pathways and may be a potential chemotherapeutic agent against colon cancer.

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