Decreased social interaction in the RHA rat model of schizophrenia-relevant features: modulation by neonatal handling

We sought to determine if sickness behaviors (decreased social interaction and pain) are induced in a rat model of work-related overuse and effectiveness of anti-inflammatory treatments. Rats first trained to learn a high force reaching task (15 min/week day for 6 wks), with subsets treated prophylactically with ibuprofen or anti-TNFalpha. Others performed a high repetition high force (HRHF) task for 6 or 12 weeks (2 hrs/day, 3 days/wk) untreated, or with ibuprofen, anti-TNFalpha or rest treatments beginning task week 5. Untreated HRHF rats had increased IL-1beta, IL-6 and TNFalpha in serum and brain, increased Substance P in spinal cord, decreased social interaction and increased forepaw allodynia. Secondary anti-inflammatory treatments attenuated social interaction and brain changes, but not allodynia or spinal cord changes; rest provided partial attenuation. Prophylactic treatments prevented all changes. Thus, inflammatory mechanisms mediate the development of sickness behaviors induced by work-related overuse, but not maintenance of allodynia.

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Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model

Neuropsychopharmacology ◽

10.1038/npp.2017.40 ◽

2017 ◽

Vol 42 (7) ◽

pp. 1447-1457 ◽

Cited By ~ 37

Author(s):

Ashleigh L Osborne ◽

Nadia Solowij ◽

Ilijana Babic ◽

Xu-Feng Huang ◽

Katrina Weston-Green

Keyword(s):

Working Memory ◽

Social Interaction ◽

Rat Model ◽

Poly I:C ◽

Interaction Recognition ◽

Prenatal Infection

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Effects of neonatal handling on social memory, social interaction, and number of oxytocin and vasopressin neurons in rats

Hormones and Behavior ◽

10.1016/j.yhbeh.2009.03.006 ◽

2009 ◽

Vol 56 (1) ◽

pp. 93-100 ◽

Cited By ~ 59

Author(s):

Anelise S. Todeschin ◽

Elisa C. Winkelmann-Duarte ◽

Maria Helena Vianna Jacob ◽

Bruno Carlo Cerpa Aranda ◽

Silvana Jacobs ◽

...

Keyword(s):

Social Interaction ◽

Social Memory ◽

Neonatal Handling ◽

Vasopressin Neurons

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Physical exercise and catecholamine reuptake inhibitors affect orienting behavior and social interaction in a rat model of attention-deficit/hyperactivity disorder.

Behavioral Neuroscience ◽

10.1037/a0030488 ◽

2012 ◽

Vol 126 (6) ◽

pp. 762-771 ◽

Cited By ~ 17

Author(s):

Andrea M. Robinson ◽

Rachel L. Eggleston ◽

David J. Bucci

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Social Interaction ◽

Physical Exercise ◽

Rat Model ◽

Attention Deficit ◽

Hyperactivity Disorder ◽

Orienting Behavior

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Injections of NGF Into Neonatal Frontal Cortex Decrease Social Interaction as Adults: A Rat Model of Schizophrenia

Schizophrenia Bulletin ◽

10.1093/schbul/sbm039 ◽

2007 ◽

Vol 34 (1) ◽

pp. 127-136 ◽

Cited By ~ 14

Author(s):

N. L. Lazar ◽

N. Rajakumar ◽

D. P. Cain

Keyword(s):

Social Interaction ◽

Frontal Cortex ◽

Rat Model

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Tryptophan and Kynurenic Acid May Produce an Amplified Effect in Central Fatigue Induced by Chronic Sleep Disorder

International Journal of Tryptophan Research ◽

10.4137/ijtr.s14084 ◽

2014 ◽

Vol 7 ◽

pp. IJTR.S14084 ◽

Cited By ~ 11

Author(s):

Masatoshi Yamashita ◽

Takanobu Yamamoto

Keyword(s):

Social Interaction ◽

Sleep Disorder ◽

Rat Model ◽

Kynurenic Acid ◽

Central Fatigue ◽

Treadmill Test ◽

Running Performance ◽

The Brain ◽

Interaction Test ◽

Chronic Sleep

Tryptophan (TRP) and its neuroactive metabolite, kynurenic acid (KYNA), are thought to play key roles in central fatigue, but the specifics are still unknown. To clarify their roles in the brain, we developed a rat model of central fatigue induced by chronic sleep disorder (CFSD) by disturbing the sleep-wake cycle. Results showed that while 5-hydroxytryptamine (5-HT) concentration did not differ between control and CFSD groups, levels of TRP and KYNA in the CFSD group were about 2 and 5 times higher in the hypothalamus, and 2 and 3.5 times higher in the hippocampus, respectively. Moreover, CFSD-induced fatigue led to abnormal running performance (via treadmill test) and social interaction (via social-interaction test). These results support a TRP-KYNA hypothesis in central fatigue in which increased TRP concentration in the brain and subsequently synthesized KYNA may produce an amplified effect on central fatigue, with enhanced concentrations being a possible mechanism by which social-interaction deficits are generated.

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