Cell-based electrochemical cytosensor for rapid and sensitive evaluation of the anticancer effects of saponin on human malignant melanoma cells

2021 ◽  
pp. 107813
Author(s):  
Won Hur ◽  
Seong Eun Son ◽  
Seong Nyeon Kim ◽  
Gi Hun Seong
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Cells ◽  
Human Malignant Melanoma ◽  
Anticancer Effects

scholarly journals Anti-Cancer Effects of Lactobacillus plantarum L-14 Cell-Free Extract on Human Malignant Melanoma A375 Cells

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3895 ◽  
Author(s):  
Jaehyun Park ◽  
Mijin Kwon ◽  
Jaehoon Lee ◽  
Sangkyu Park ◽  
Jeongmin Seo ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Lactobacillus Plantarum ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Migration Ability ◽  
Human Malignant Melanoma ◽  
Anticancer Effects ◽  
Human Melanoma Cells ◽  
L 14 ◽  
A375 Cells

Human malignant melanoma is the most aggressive type of skin cancer with high metastatic ability. Despite several traditional therapies, the mortality rate remains high. Lactobacillus plantarum (L. plantarum), a species of lactic acid bacteria (LAB), is being studied for human health, including cancer treatment. However, few studies have elucidated the relationship between L. plantarum extract and human malignant melanoma. To investigate the effects of L. plantarum on human melanoma cells, A375 human melanoma cells were used and treated with L. plantarum L-14 extract. After the treatment, viability, migration ability, molecular changes of migration- and apoptosis-related genes, and the location of cytochrome c was evaluated. The L-14 extract inhibited the viability, migration of A375 cells as well as reduced expression of migration-related genes. In addition, it was confirmed that the L-14 extract induced intrinsic apoptosis in A375 cells. This study demonstrated that the L-14 extract exerted anticancer effects on A375 cells. Therefore, these data suggest that the L-14 extract is worth studying for the development of melanoma drugs using LAB.

scholarly journals Toxicogenomics of A375 human malignant melanoma cells treated with arbutin

2006 ◽  
Vol 14 (1) ◽  
pp. 87-105 ◽  
Author(s):  
Sun-Long Cheng ◽  
Rosa Huang Liu ◽  
Jin-Nan Sheu ◽  
Shui-Tein Chen ◽  
Supachok Sinchaikul ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Cells ◽  
Human Malignant Melanoma
Sign in / Sign up

Export Citation Format

Share Document